Stockwell Lab

Columbia News: Paper Offers New Details on a Form of Cell Death Discovered at Columbia [Feb 2023]
Identification of essential sites of lipid peroxidation in ferroptosis. [Feb 2023]
Small Molecule Allosteric inhibitors of GPX4. [Nov 2022]
Joleen Csuka interviewed about her Astrobiology work involving lava tube biosignatures on national Icelandic TV program Kveikur [Nov 2022]
Vitamin K: A new guardian against ferroptosis. [Oct 2022]
Video of Prof. Stockwell demonstrating to the staff at the Columbia Center for Teaching and Learning how to teach biochemistry using virtual reality. [Sept 2022]
Dr. Brent Stockwell Is Named Chair of Biological Sciences and Celebrates a Milestone in Cell Death Research. [July 2022]
10 Years On, a Cell Death Discovery Shows Promise for Treating Disease. [July 2022]
Timeline of ferroptosis papers in PubMed. [July 2022]
A Study in Blue: Secondary Copper-rich Minerals and their Associated Bacterial Diversity in Icelandic Lava Tubes. [Apr 2022]
Development of optimized drug-like small molecule inhibitors of the SARS-CoV-2 3CL protease for treatment of COVID-19. [Apr 2022]
Machine Learning Classifies Ferroptosis and Apoptosis Cell Death Modalities with TfR1 Immunostaining. [Mar 2022]
Characterization of a patient-derived variant of GPX4 and analysis of potential for precision therapy. [Dec 2021]
Teaching with VR. [Sept 2021]
Lead compounds for the development of SARS-CoV-2 3CL protease inhibitors. [Apr 2021]
Mayor Bill de Blasio visits Stockwell Lab at Columbia University -- learns about drug discovery. [Mar 2021]
Ferroptosis: mechanisms, biology and role in disease. [Jan 2021]
p21 can be a barrier to ferroptosis independent of p53. [Sep 2020]
Mesenchymal Subtype Neuroblastomas Are Addicted to TGF-βR2/HMGCR-driven Protein Geranylgeranylation. [Jul 2020]
SnapShot: Ferroptosis. [May 2020]
Time Course of Changes in Sorafenib-Treated Hepatocellular Carcinoma (HCC) Cells Suggests Involvement of Phospho-Regulated Signaling in Ferroptosis Induction. [Apr 2020]
The chemistry and biology of ferroptosis. [Apr 2020]
Emerging Mechanisms and Disease Relevance of Ferroptosis. [Mar 2020]
Transferrin Receptor Is a Specific Ferroptosis Marker. [Mar 2020]
MDM2 and MDMX promote ferroptosis by PPARα-mediated lipid remodeling. [Feb 2020]
Patient-derived glioblastoma cultures as a tool for small-molecule drug discovery. [Jan 2020]
Radiation-Induced Lipid Peroxidation Triggers Ferroptosis and Synergizes with Ferroptosis Inducers. [Jan 2020]
GTP Cyclohydrolase 1/Tetrahydrobiopterin Counteract Ferroptosis through Lipid Remodeling. [Dec 2019]
Congrats Dr. Ling Feng on a successful defense. [Dec 2019]
Congrats Prof. Brent Stockwell for being named a 2019 Highly Cited Researcher. (link)
Dawn of a New Era of Targeted Antioxidant Therapies. [Nov 2019]
Development of MAP4 Kinase Inhibitors as Motor Neuron-Protecting Agents. Prosetin (formerly known as prostetin) is not approved for human use. It is currently being studied in animals. [Oct 2019]
Powerful system for cell protection revealed. [Oct 2019]
Intercellular interaction dictates cancer cell ferroptosis via NF2-YAP signalling. [Jul 2019]
A Physiological Function for Ferroptosis in Tumor Suppression by the Immune System. [Jul 2019]
K-RasG12D Has a Potential Allosteric Small Molecule Binding Site. [May 2019]
Imidazole Ketone Erastin Induces Ferroptosis and Slows Tumor Growth in a Mouse Lymphoma Model. [Feb 2019]
The Hallmarks of Ferroptosis. [Jan 2019]
The Development of the Concept of Ferroptosis. [Sep 2018]
Regulation of lipid peroxidation and ferroptosis in diverse species. [May 2018]
Unsolved mysteries: How does lipid peroxidation cause ferroptosis? [May 2018]
Increased erythrophagocytosis induces ferroptosis in red pulp macrophages in a mouse model of transfusion. [Apr 2018]
FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation. [Apr 2018]
Targeting Dependency on the GPX4 Lipid Peroxide Repair Pathway for Cancer Therapy. [Mar 2018]
Copper-Binding Small Molecule Induces Oxidative Stress and Cell-Cycle Arrest in Glioblastoma-Patient-Derived Cells. [Mar 2018]
Modeling the effects of lipid peroxidation during ferroptosis on membrane properties. [Mar 2018]
Determination of the subcellular localization and mechanism of action of ferrostatins in suppressing ferroptosis. [Feb 2018]
Small molecule modulator of protein disulfide isomerase attenuates mutant huntingtin toxicity and inhibits endoplasmic reticulum stress in a mouse model of Huntington's disease. [Feb 2018]
Towards a microparticle-based system for pooled assays of small molecules in cellular contexts. [Jan 2018]
Design of small molecules that compete with nucleotide binding to an engineered oncogenic KRAS allele. [Jan 2018]
Transforming Lipoxygenases: PE-Specific Enzymes in Disguise [Oct 2017]
Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease. [Oct 2017]
Michael successfully defended his PhD thesis. Congratulations Michael! [July 2017]
Lipid homeostasis and regulated cell death. [June 2017]
Heavy Metal Suicide. [May 2017]
Group Problem Solving in Class Improves Undergraduate Learning. [May 2017]
Inhibition of neuronal ferroptosis protects hemorrhagic brain. [Apr 2017]
Multivalent Small-Molecule Pan-RAS Inhibitors. [Feb 2017]
Animation of Ferroptosis. [Feb 2017]
Lipid peroxidation in cell death. [Feb 2017]
Development of a primary microglia screening assay and its use to characterize inhibition of system xc- by erastin and its analogs. [Jan 2017]
Heat stress induces ferroptosis-like cell death in plants. [Jan 2017]
Oxidized Arachidonic and Adrenic PEs Navigate Cells to Ferroptosis. [Dec 2016]
Discovery of anticancer agents of diverse natural origin. [Nov 2016]
A mitochondrial-targeted nitroxide is a potent inhibitor of ferroptosis. [Sept 2016]
Clickable Poly(ionic liquids): A Materials Platform for Transfection. [Sept 2016]
Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis. [July 2016]
Transforming Big Data into cancer-relevant insight: An initial, multi-tier approach to assess reproducibility and relevance . [July 2016]
Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis. [May 2016]
Cell-line selectivity improves the predictive power of pharmacogenomic analyses and helps identify NADPH as biomarker for ferroptosis sensitivity. [Feb 2016]
Regulated necrosis: disease relevance and therapeutic opportunities. [Jan 2016]
Ferroptosis: Death by lipid peroxidation. [Nov 2015]
tRNA synthase suppression activates de novo cysteine synthesis to compensate for cystine and glutathione deprivation during ferroptosis. [Nov 2015]
Professor Stockwell delivers University Lecture on teaching and learning. [Oct 2015]
Blended Learning: The Stockwells Marry Their Expertise to Test Teaching Methods. [Aug 2015]
Blended learning improves science education. [Aug 2015]
Structural elucidation of a small molecule inhibitor of protein disulfide isomerase. [Jul 2015]
Incorporation of metabolically stable ketones into a small molecule probe to increase potency and water solubility. [Jul 2015]
Loss of cysteinyl-tRNA synthetase (CARS) induces the transsulfuration pathway and inhibits ferroptosis induced by cystine deprivation. [Jul 2015]
Elucidating compound mechanism of action by network perturbation analysis.[Jul 2015]
High-throughput screening of patient-derived culture reveals potential for precision medicine in glioblastoma. [Jun 2015]
Human haploid cell genetics reveals roles for lipid metabolism genes in nonapoptotic cell death. [May 2015]
Small molecule-induced oxidation of protein disulfide isomerase is neuroprotective. [Apr 2015]
Blended Learning in Biochemistry at Columbia [Apr 2015]
Professor Stockwell discusses the benefits of technology in education. [Mar 2015]
Professor Stockwell speaks at Columbia CCNMTL rewirED Showcase. [Dec 2014]
Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. [Nov 2014]
Synchronized renal tubular cell death involves ferroptosis. [Nov 2014]
Regulated cell death and inflammation: an auto-amplification loop causes organ failure. [Oct 2014]
Unraveling the mechanism of cell death induced by chemical fibrils. [Sep 2014]
Essential versus accessory aspects of cell death: recommendations of the NCCD 2015. [Sep 2014]
Professor Stockwell was named a National Academies Education Fellows in the Sciences for the 2014-15 academic year.[Sep 2014]
Multidimensional profiling in the investigation of small-molecule-induced cell death.[Jul 2014]
Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis.[May 2014]
Professor Stockwell describes innovations in teaching undergraduate biochemistry in ASBMB Today.[May 2014]
Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models.[Mar 2014]
Regulation of Ferroptotic Cancer Cell Death by GPX4.[Jan 2014]
The role of iron and reactive oxygen species in cell death.[Dec 2013]
Technologies available from the Stockwell Lab through Columbia Technology Ventures
Synthesis Facility has officially been launched.[Apr 2012]
Read a story about Brent Stockwell in Columbia Magazine called "The Long Shot" [Mar 2012]
Professor Stockwell has been featured in Columbia News.

Professor Stockwell's book The Quest for the Cure is now available. (book's page in Amazon.)