C2005/F2401 '10 -- Outline for Lecture #23

Last Updated 12/08/10 02:40 PM .

I. Wrap up of Linkage & Crossing Over

    A. How is Linkage measured
    B. Limits of RF
    C. Mapping -- How is linkage used?

II. Population Genetics
    A. Pot (population) thinking -- how to analyze the genetics of a population as vs. an individual
    B. Genetic Equilibrium & the Hardy-Weinberg Law
        1. What the H-W Law is
        2. How it is used
        3. When it applies & what to do if it doesn't

III. Micro-Evolution -- if there is no genetic equilibrium, why not? What causes changes in the genotype of a population?
    A. Mutation & Migration
    B. Non Random Mating
    C. Genetic Drift -- effects of small population size
    D. Selection

IV. How does Selection Work?
    A. Two models
        1. Differential reproduction of pre-existing variants → adaptation of populations
        2. Variation produced in response to the conditions of life → adaptation of individuals
    B. Evidence -- which model fits known data?
    C. Consequences of how selection works
        1. Why don't deleterious alleles disappear? Genetic load & heterozygote advantage   
        2. Why some regions of DNA vary more than others -- conservative role of selection
        3. Are there social implications of all this?