Figure 3.15 in the Purves book depicting peptide bond formation seems to
conflict with Fig 3.3 in the Becker book. Specifically, why does the
amino group pictured in the Purves book have only 2 hydrogens bonded in
the free amino group?
Purves (Fig. 3.15) writes the free amino acid prior to peptide bond
formation as having an amino group with 2 H's, and uncharged, as it might occur in
the solid powder. Becker writes it as it exists predominantly in
solution, with 3 H's and a positive charge, having taken up a hydrogen ion
from water. He is consistent in writing the carboxyl as also ionized, with no
H in sight. Either way, you can extract 2 H's and and O,
forming a free water molecule and the peptide bond. Although the ionized
form is more accurate, the withdrawal of water is easier to see in the
un-ionized form, as I wrote in class. The result is the same. The
actual mechanism of peptide bond formation is actually much more
complicated than this, as you will soon learn. These reaction schemes merely
summarize the molecules that you start with and end up with.