rl13.html

Biology C2005/F2401 - 2013 Intro Bio
Schedule of Lectures, recommended readings, exams, and download links
Students with older editions of the texts can consult older reading lists and find the readings for the same topics.
To study lecture material in advance you may access those from last year which are usually very similar.
See additional notes below.

++Download codes:

LH, lecture notes in html;
LP, lecture notes as pdf;
O, outline

M, mp3 audio of lecture
W, WMA audio of lecture;
Q, QuickTime movie of eve. lec. PPT ... .....sync'd to audio (new, experimental)
PP, PowerPoint used in lecture

For readings:
B = Becker 8^th ed.
S = Savada 10^th ed.
(9^th ed. of S is in paren. if different.)

Lecture notes, recording, etc. added as we go.

Lecture:
(C)hasin
(M)owsh.

Date

Subject of Lecture

Recommended reading in Becker or Sadava

Downloads++

1 (C)

Tu
9/3/13

Introduction. Living things. Cells. Exponential growth. Water.

B: Ch.1;Ch.2:18-32; Ch.4:75-79
S: Ch 1 + Ch 5.1+5.2

2 (C)

Th
9/5/13

Water contd. Strong and weak chemical bonds. Small vs. large molecules. Bio-polymers. Acids and bases. Sugars. Polysaccharides.

B: Ch.3: 46-47; 60-66
S: Ch.2; Ch 3.1, 3.3

3 (C)

Tu
9/10/13

Polysaccharides cont. Lipids. Phospholipids. Membranes.

B: Ch.3: 65-70; Ch7: 167-173
S: Ch. 3.4; Ch 6.1

4 (C)

Th
9/12/13

Amino acids. Stereo-isomers. Protein structure. Peptide bonds. Small molecule separation methods.

B: Ch.3: 41-48; Ch.2: 21-22
S: Ch. 3.2

5 (C)

Tu
9/17/13

Alpha helix. Beta sheet. 3-D structure. Subunit interaction. Domains.

B: Ch. 3: 48-54
S: Ch. 3.2 again

6 (C)

Th
9/19/13

Prosthetic groups. Membrane proteins. Catalysis. Enzymes. Protein purification methods. Chemical kinetics.

B: Ch.7:161-162,179
S: Ch. 8.3 and 8.4

7 (C)

Tu
9/24/14

Enzyme kinetics. Enzyme inhibitors. Feedback inhibition. Free energy and the direction of chemical reactions. ATP hydrolysis.

B: Ch. 6; Ch.5
S: Ch. 8.5 then 8.1 and 8.2

N/A

8 (C)

Th 9/26/13

Glycolysis as a pathway in intermediary metabolism. Anaerobiosis. Krebs (TCA) cycle. Electron transport.

B: Ch.9: 224-238
S: Ch.9.1 and 9.2

9 (C)

Tu
10/1/13

Oxidative phosphorylation. Alternative energy sources. Biosynthetic pathways.

B: Ch.10
S: Ch 9.3 to 9.5
Required: "Carbon" by P. Levi
Optional skim: B:Ch.11/S:Ch.10

Exam#1

Th
10/3/13

Exam #1.
Covers topics listed for lectures 1 - 8. See Exam 1 page for details.

Note exams are not at morning class times.
Optional review session (Q & A) held at the morning class time and place

5:40 - 7:20 PM or 7:30 - 9:10M
EXAM 1 INFO page will be posted with links to room and time assignments.**

10 (M; C)

Tu
10/8/13
Drop deadline -- don't panic; see announcements

C: Finish metaboloism: ATP synthetase
M: DNA as hereditary material. Nucleic acid structure. Introduction to DNA replication

B: Ch. 3:54-60 + Box 3A;Ch. 18:505-517
S: Ch. 4.1,
13.1 & 13.2 & fig. 15.18 (14.8)

M-lac

M-dbm

W-lac

W-dbm

11(M)

Th
10/10/13

Wrap up of DNA structure; Details of DNA synthesis

B: Ch. 19:551-567
S: Ch. 13.3 & 13.4

12 (M)

Tu
10/15/13

PCR

Transcription & the central dogma

B: Box 19A
S: Ch. 13.5
B: Ch. 21: 645-660 & 674-end.
S: Ch. 14.1 -14.3

13 (M)

Th
10/17/13

Wrap up of transcription; Intro to Translation and the genetic code.

B: Ch. 22 to p. 693
S: Ch. 14.5 (14.4 below; 14.6 next term)

14 (M)

Tu
10/22/13

Translation & the genetic code, cont.; Mutation (will finish in #15 if necessary)

B: Ch. 22: 693-695
S: Ch. 15.1

Exam #2

Th
10/24/13

Exam #2. Covers topics of lectures 9 - 13 inclusive. (See Exam 2 page for details.) Optional review session (Q & A) at morning class time and place.

5:40 - 7:20 PM and
7:30 - 9:10PM **
Room(s) TBA

15 (M)

Tu
10/29/13

Regulation of protein synthesis in prokaryotes.

B: Ch. 23 to p. 718.
S: Ch. 16.1 (16.2)

16 (M)

Th
10/31/13

Bacterial and viral reproduction.

B: Ch. 20: 620-624 & Box 18A (p.508-509)
S: Ch. 12.6 & 16.3 (16.1)

Tu
11/5/13

ELECTION DAY - NO CLASS

17 (M)

Th
11/7/13

Bacterial & Viral reproduction, cont. &

Recombinant DNA technology I. Restriction enzymes & forensics. Blots and probes.

B: Ch. 18: 518-520
& Boxes 18B & 18C
S: Ch. 15.3 (15.2)

18 (M)

Tu
11/12/13

Recombinant DNA tech. II. Molecular cloning;

Discoveries about Eukaryotic gene/genome structure. Introns and exons.

B: Ch 20: 628-end.
S. Ch. 18
B: Ch. 21: 669-674.
S: Ch. 14.4

19 (M)

Th
11/14/13
P/F deadline

Eukaryotic cell division I: Mitosis and the cell cycle (details of cell cycle and chromosome structure next term); intro to meiosis

B: Ch. 19: 549-551 & 571-580.
S: Ch. 11.1-11.3

20 (M)

Tu
11/19/13

Eukaryotic cell division II & Intro to eukaryotic genetics: Meiosis & its consequences -- sex determination, non- disjunction, life cycles and intro to simple inheritance.

B: Ch. 20: to p 612.
S: Ch. 11.4-11.5

Exam #3

Th
11/21/13

Exam #3: Covers topics of lectures 14-19 (See Exam 3 Page for details). Optional review session (Q & A) at morning class time and place.

5:40 - 7:20 PM and
7:30 - 9:10 PM **
Room(s) TBA

21(M)

Tu
11/26/13

Eukaryotic Genetics I: One gene at a time. Crosses & Genetic diseases.

B: Ch. 20: 612-618
S: Ch. 12.1, 12.2, & 12.4 pp. 249-252 (256-259). (skip dihybrid crosses for now)

Th 11/28/13

Thanksgiving holiday

22 (M)

Tu
12/3/13

Crosses with more than one gene at a time. Intro to Linkage and mapping

B: Ch. 20: 618-620
S: Ch. 12.3 & 12.4; Ch. 15.2, 15.4, & 15.5 (15.3-15.6)

23 (M)

Th
12/5/13

Wrap up of linkage; Darwinian evolution, population genetics and molecular evolution

S: Ch. 1.1 (1.1 & & 1.2); Ch. 21 & Ch. 24

Review (M)

TBA

Optional, date and room TBA

FINAL EXAM

Tu
12/17/13
4:10-7:00
&7:10-10

Exam #4. EMPHASIZES LECTURES 20 - 23, but will refer back to entire course.
Important: This is not the usual date & time for a class that meets Tu-Th at 10:35 or 5:40. Please take this into account when buying tickets to go home.

Rooms TBA

**Exams are designed to be completed in 75 minutes, but additional time is scheduled. Students with a class conflict at 5:40 exam may take the exam at 7:30 (requires permission including proof of class conflict: CU SSOL printout of schedule). Students with class conflicts at the assigned time or at both 5:40 AND 7:30 should contact Paige Thompson ([email protected]) to search for an alternative.

++Download codes:

LH, lecture notes in html, best for viewing on a screen

LP, lecture notes as pdf, best for printing

M, audio of lecture in mp3 format

W, audio of lecture in WMA format

PP, PowerPoint, if used in lecture

O, outlines for lectures 10-end.

Q, QuickTime movie (.m4a) of PowerPoint synchronized with audio of evening lecture (~ 40 MB)

If you have trouble getting the m4a file to open in QuickTime by clicking in your browser, or the display is too small, save it to a folder on your computer, open QuickTime Player, and then open the lecX_10.m4a file in QuickTime. QuickTime Player can be downloaded here (iTunes not needed). You may need v. 7.6.6 or later.

Web lectures and outlines are usually provided by the early morning hours before live lectures 1-9. Materials for lectures 10-23 are usually ready by 9 pm the night before. All of the 2012 lectures are available for those who want to look ahead. (See link at top of page.) There are links to figures in the 9th ed. of Savada embedded in the lectures. Answered questions posed by students in previous years are also provided: follow the red Q&A links to see a more complete explanation; the green Q&A links expand upon a subject.

Savada and Purves refer to the same basic text: Sadava is the first author from the 8th edition on, Purves was the first author of editions 1-7.

Note: Regarding exams, students are responsible for the material presented in lectures, the Web lectures, the handouts, and the problems. The texts should be used to help understand the lectures; you are not responsible for any topics or information that is in the text but not in the live and Web lectures, handouts, or problems. Additional material is sometimes provided in the Web lectures in the form of links to outside sources and links to additional pictures and diagrams. You are only responsible for the links to the handouts, hard copies of which are provided in class.