C2005/ F2401 '08 -- Outline For Lecture #21 -- Posted/updated 11/25/08 03:01 PM

 
I. What is the Pattern of Inheritance for Sex Linked Genes?

    Example of coat color (orange vs black) in cats (See handout 20B, top)

        A. What gametes are formed?

        B. What zygotes are formed?

        C. What do zygotes look like? How does genotype determine phenotype in this case?

II. What is the Pattern of Inheritance for Autosomal Genes?

        A. A Specific Example --  blue vs brown eyes  (See handout 20B, bottom)

            1. What gametes do you get? What zygotes?

            2. What do zygotes look like? The issue of dominance.

        B. The General case for Autosomal Genes

            Genotypes of offspring of AA X A*A* (in first and second generations)

            Phenotypes -- Depends on what  AA* looks like -- see below.

 III. Phenotypes & Dominance -- 4 cases (See handout 21A bottom)

A. A (Normal allele) is dominant, A* is recessive; human recessive diseases

B. A* (Mutant allele) is dominant, A is recessive; human dominant diseases.

C. Partial (= Incomplete) Dominance (Red, Pink & White)

D. Co-dominance (ABO) 

IV. Other Aspects of Dominance & Genetic Conditions

V. Treatment & Diagnosis of Genetic Diseases

VI.  (If time) Pedigrees -- How Human Inheritance Patterns are Figured Out (See handout 21A top)