We strongly advised getting a copy
of 2009 (7th) edition. It has many additional problems.
However, if you have the 2008 or
2007 editions, here are the corrections.
Problem Book -- 2008 edition -- 6th edition, revised.
Problems 6-20 & 6-21. For unknown reasons, the Greek symbols in these problems did not print, and there are spaces instead. Where it says 1 and 2 receptors it should say α1 and α2 receptors. Where it says / it should say β/δ. (There is a missing β & δ in the description of experiment (4) in the table, and in the sentence after the end of 6-21, part C-3.) A correct version of both problems is posted in Word.
Answer to 3-6. The term 'transit peptide' or 'TP' is used loosely in this answer to mean any localization signal for a mitochondrial protein. Therefore it refers to a 'first TP' (to allow entry into the matrix) and a 'second TP' (to allow insertion into the inner mitochondrial membrane.) It would be more proper to use the term 'TP' for the first localization signal only, and to use a different term for the second localization signal. (By analogy with proteins that enter the ER, the second signal could be called a signal peptide.)
Answer to 6-6, Part B. The last sentence is incomplete. It should read 'In the situation here, the system has been interfered with downstream of the protein kinase, and so has an effect on just one pathway, leading to synthesis and breakdown of glycogen at the same time.' The blue part was accidentally omitted.
Answer to 6-20, explanation of B. Last sentence should read "If PDE is inhibited...." not "If PDE is present..."
Answer to 8-2, part C. Answer should be X, not Y. Since the difference is so small, and will be corrected by the Na+/K+ pump (if it is running), X = Y is probably an equally good answer.
Answer to 12R-4. It says 'See note at end of answers.' It should say 'See note at end of answer to 12R-13.' (Note is at bottom of page 184.)
Problem Book -- Corrections for
6th edition (2007); these have been fixed in the
6th edition, revised (2008). These corrections
are in the order of the problems
Questions:
2-10, p. 11. The questions are labeled 3-A, 3-B, & 3-C. They should be labeled A, B and C. Delete the '3-' part.
2-11, p. 11. Parts C-2 & D of question 11 were accidentally omitted. Here are the missing parts:
C-2. Receptor R-1 that has bound its ligand usually ends up at the end of RME (in lysosomes) (in peroxisomes) (recycled back to the plasma membrane) (recycled or in lysosomes) (any of these) (none of these). Explain how ligand reduces the half life of receptor.
D. The half life of R-2 is unaffected by the presence
or absence of ligand. However, the amount of R-2 on the cell surface is reduced
in the presence of ligand. From these results it seems that:
D-1. Receptor R-2 separates from its ligand in (uncoated endocytic vesicles)
(coated vesicles) (endosomes) (none of these) (can’t predict).
D-2. Receptor R-2 that has bound its ligand usually ends up at the end of
RME (in lysosomes) (in peroxisomes) (recycled back to the plasma membrane)
(recycled or in lysosomes) (any of these) (none of these).
D-3. Receptor R-2 probably enters coated pits (spontaneously, whether ligand
is bound or not) (only if bound to ligand) (only if ligand is not bound) (can’t
predict).
Explain how ligand reduces the amount of receptor R-2 on the surface.
4-10, part A-3. If you get stuck, see fig 21-17 in 5th ed. of Becker or 23-17 in 6th ed.
4-12, p. 33. Part A-1. See question 10, part A-1 (not question 9) for choices.
4-14, p. 34. There are two problems labeled '4-13' on this page. The second one is problem 4-14.
4R-4, part E. The last sentence of the second line is cut off. It should read: 'The half life of cytoplasmic mRNA for Cp does not change.'
7-19. After part C, it should
say, "Which ONE of the following best explains why it is necessary to store the
hormone in part C?"
Answers
1-20, p. 109.
A. A gap junction transmembrane protein is a connexin, not a integrin or cadherin.
B. Explanation: Gap junction proteins are not directly connected to the cytoskeleton, but they must be connected indirectly. See answer to 1-14B.
p. 110. Answers given are to problems 1-21 & 1-22, not to 1-20 & 1-21.
2-6-B, p. 114. First sentence in second paragraph (about capping) should say mouse, not rabbit, when referring to the primary antibodies.
2R-2, p. 117. The questions and answers for this problem are not in the same order. Use the information in the answers to match them up properly. (Given the order of the questions, the answers are in order: A, C, D, E, B.)
3R-All. They key to 3R is missing. It was inadvertently omitted from the book. Click here for a link. (Note: this file is in Word, and must be opened by your browser).
6-18, Note at end of A-2. Answer has a typo -- the third word in line two of the note is 'GTP.' Cross out 'GTP' and replace it with 'the G protein.' First sentence should read: 'G proteins are activated by GDP/GTP exchange, not by phosphorylating the GDP which is already bound to the G protein.'
6-21-C3, p. 147. It should say at end of line 2 "-- the beta/gamma binding proteins do not block Ca++ release in cells with alpha-1 receptors." Alpha-1 receptors, not alpha-2.