1. Reverse genetics

  2. Methods of mutating genes

    1. Targeted recombination

    2. Targeted knock in mice

    3. Drosophila method (Rong and Golic)

    4. Sib selection in C. elegans

    5. RNAi

  3. Obtaining Genomic Sequences – The C. elegans Model

    1. Obtaining a Physical Map

    2. Sequencing and the idea of multiple coverage

    3. Identifying genes – Genefinder

    4. Confirmation of gene models

    5. Using the data

    6. Some comments on genomic data and the Public/Private Efforts