W4799 - Readings in the Molecular Biology of Cancer - Spring 2004

 

Instructor: Dr. Lili Yamasaki Lectures: Tues/Thurs 2:40 3:55 pm

1102 Fairchild Building

Department of Biological Sciences Office Hours: Wed 3:00 4:00 pm

854-4384 office

ly63@columbia.edu

 

Textbooks: Oncogenes Geoffrey M. Cooper, 2nd Ed., 1995

One Renegade Cell - How Cancer Begins Robert A. Weinberg, 1999

 

Readings: Reviews and Primary Papers - To Be Assigned

Schedule of Topics and Textbook Reading

 

January 20 (T) Overview of Cancer - Mutations and Epidemiology Weinberg, Chapters 1, 2

 

January 22 (Th) The Cell Cycle and Model Systems Cooper, Chapter 1

Papers

January 27 (T) DNA Tumor Viruses Cooper, Chapter 2

Papers

 

January 29 (Th) RNA Tumor Viruses Cooper, Chapters 3, 4

Weinberg, Chapter 3

Papers

 

February 3 (T) Proto-Oncogenes and Oncogene Activation Cooper, Chapters 5, 6

Weinberg, Chapter 4

Papers

 

February 5 (Th) Chromosomal Translocations and Amplifications Cooper, Chapters 7, 8

Papers

 

February 10 (T) Growth Factors, Tyrosine Kinases (receptor, non-receptor) Cooper, Chapters 12, 13

Papers

 

February 12 (Th) Ras Superfamily and SH2/SH3 Adaptor Proteins Cooper, Chapter 14

Papers

 

February 17 (T) MAP Kinase Pathways and Signal Transduction Cooper, Chapters 15, 17

Papers

 

February 19 (Th) EXAM I

 

February 24 (T) Multistep Tumor Development Cooper, Chapter 11

Weinberg, Chapters 5, 6

Papers

February 26 (Th) Retinoblastoma Tumor Suppressor (pRB)

Cooper, Chapter 9

Weinberg, Chapter 7

Papers

 

March 2 (T) p53

Cooper, Chapter 10

Papers

 

March 4 (Th) Cyclins, CDKs, CKIs, and the INK4A/ARF Locus

Weinberg, Chapter 14

Papers

 

March 9 (T) Ubiquitin Pathway and Cell Cycle Control

Papers

 

March 11 (Th) Apoptosis and its Effectors

Weinberg, Chapter 13

Papers

 

March 16 - 18 SPRING BREAK (No Classes)

Weinberg, Chapters 10, 11

 

March 23 (T) Senescence, Immortalization and Telomerase

Weinberg, Chapter 12

Papers

 

March 25 (Th) Student Presentations

 

March 30 (T) EXAM II

 

April 1 (Th) NF1, NF2 Tumor Suppressors

Papers

 

April 6 (T) WT1 and VHL Tumor Suppressors

Papers

 

April 8 (Th) APC and b-Catenin Pathway

Weinberg, Chapter 8

Papers

 

April 13 (T) MSH2, MLH1, PMS1-2 and Mismatch Repair

Weinberg, Chapter 9

Papers

 

April 15 (Th) DNA Repair (Double-Strand Break Repair and NER)

Papers

 

April 20 (T) ATM/ATR and BRCA1/BRCA2

Papers

 

April 22 (Th) Angiogenesis and A Look Ahead

Weinberg, Chapters 15, 16

Papers

April 27 (T) Student Presentations (no lecture)

 

April 29 (Th) Student Presentations (no lecture)

Last Day of Class

 

T.B.A. FINAL EXAM

 

 

 

GRADING

30-MIN PRESENTATION 10%

EXAM I 30%

EXAM II 30%

EXAM III (FINAL) 30%