W4799
-
Instructor: Dr. Lili Yamasaki Lectures: Tues/Thurs
1102
Department of Biological
Sciences Office Hours: Wed
854-4384 office
ly63@columbia.edu
Textbooks: Oncogenes Geoffrey M.
Cooper, 2nd Ed., 1995
One Renegade Cell - How
Cancer Begins Robert A.
Weinberg, 1999
Schedule
of Topics and
Textbook
January 20
(T) Overview
of Cancer - Mutations and Epidemiology Weinberg, Chapters
1, 2
January 22
(Th) The Cell Cycle and Model Systems Cooper, Chapter 1
Papers
January 27
(T) DNA
Tumor Viruses Cooper, Chapter 2
Papers
January 29
(Th) RNA
Tumor Viruses Cooper, Chapters 3,
4
Weinberg, Chapter 3
Papers
February 3
(T) Proto-Oncogenes
and Oncogene Activation Cooper, Chapters 5,
6
Weinberg, Chapter 4
Papers
February 5
(Th) Chromosomal
Translocations and Amplifications Cooper, Chapters 7,
8
Papers
February 10
(T) Growth
Factors, Tyrosine Kinases (receptor, non-receptor) Cooper,
Chapters 12, 13
Papers
February 12
(Th) Ras
Superfamily and SH2/SH3 Adaptor Proteins Cooper, Chapter 14
Papers
February 17
(T) MAP
Kinase Pathways and Signal Transduction Cooper, Chapters
15, 17
Papers
February 19 (Th) EXAM I
February 24
(T) Multistep
Tumor Development Cooper, Chapter 11
Weinberg, Chapters
5, 6
Papers
February 26
(Th) Retinoblastoma
Tumor Suppressor (pRB)
Cooper, Chapter 9
Weinberg, Chapter 7
Papers
March 2 (T) p53
Cooper, Chapter 10
Papers
March 4 (Th) Cyclins,
CDKs, CKIs, and the INK4A/ARF Locus
Weinberg, Chapter
14
Papers
March 9 (T) Ubiquitin
Pathway and Cell Cycle Control
Papers
March 11 (Th) Apoptosis
and its Effectors
Weinberg, Chapter
13
Papers
March 16 - 18 SPRING BREAK (No Classes)
Weinberg, Chapters
10, 11
March 23 (T) Senescence, Immortalization and
Telomerase
Weinberg, Chapter
12
Papers
March 25 (Th) Student Presentations
March 30 (T) EXAM II
April 1 (Th) NF1,
NF2 Tumor Suppressors
Papers
April 6 (T) WT1
and VHL Tumor Suppressors
Papers
April 8 (Th) APC and b-Catenin Pathway
Weinberg, Chapter 8
Papers
April 13 (T) MSH2, MLH1, PMS1-2 and Mismatch
Repair
Weinberg, Chapter 9
Papers
April 15 (Th) DNA Repair (Double-Strand
Break Repair and NER)
Papers
April 20 (T) ATM/ATR and BRCA1/BRCA2
Papers
April 22 (Th) Angiogenesis
and A Look Ahead
Weinberg, Chapters
15, 16
Papers
April 27 (T) Student
Presentations (no lecture)
April 29 (Th) Student
Presentations (no lecture)
Last Day of Class
T.B.A. FINAL EXAM
GRADING
30-MIN
PRESENTATION 10%
EXAM I 30%
EXAM II 30%
EXAM III (FINAL) 30%