Columbia University

Department of Biological Sciences

G4008y: Advanced Seminar in Neurobiology

Dendritic Integration: Spines

Spring 2002- Syllabus

Updated Thursday, November 15, 2001

 

Meetings: Wednesdays 9.10-11am in Rm. 1000 Fairchild

Instructor:  Rafael Yuste, 1002 Fairchild, rmy5@columbia.edu, 854-2354 

Office Hours: Tuesdays 5-6pm

 

PRIMARY TEXT: papers and reviews will be distributed

 

ADDITIONAL READING:

The Theoretical Foundations of Dendritic Function. Segev, Rinzel and Shepherd (Eds.) 1st Edition, MIT press, 1995

Foundations of Cellular Neurophysiology. Johnston and Wu, MIT Press, 1995.

Dendrites. Stuart, Spruston and Hausser. Oxford University Press, 1999.

 

STUDENTS: 12 maximum

 

REQUIREMENTS: This course is seminar-style and is designed towards graduate students with knowledge of electrophysiology. Active participation in every session is expected. Undergraduates, master students or auditors need previous approval from instructor.

 

CREDITS: 3

EXAMS: One take-home exam at the end of the semester. Each student also will present at least 1 paper during the course. The final grade will take into account exam performance (40%), paper presentation (30%) and class participation (30%).

 

Photocopy code TBA

 

Schedule meetings:

 

Jan 23rd: Introduction to spines

                        Why spines are important

                        Techniques to study spines

                                    EM

                                    2Photon

                                    confocal

                                    cultures

                                    slices

                                    modeling

                        Questions raised: function of spine?

                        Course organization and paper assignment

 

Jan 30^th: Spine History

                        Cajal 88

                        Gray 58

                        Shepherd

                        Peters and Kaiserman

 

Feb 6^th: Spine Structure

                        Nusser and Somogyi, Neuron

                        Harris and Kater, ARN, 1994

 

Feb 13^th: Spine modeling

                        Koch’s chapter

                        Johnston chapter

                        Rall

 

Feb 20th^:: Spine Development-1

                        Sotelo

                        Miller and Peters

                        Harris

                        Vaughn

 

Feb 27^th: Spine Development-2: Filopodia

                        Ziv and Smith

                        Dailey and Smith

                        Fiala

                        Portera and Yuste, N, 2002

 

March 6^th: Spine physiology

                        Schikorski,

                        Harris

                        Matsusaki 01

 

March 13^th: Spine calcium-1

                        Yuste and Denk

                        Svoboda 95

                        Yuste et al., NN 2000

 

March 20^th: No seminar, Spring break

 

 

March 27^th: Spine calcium-2

                        Majewska 00a

                        Sabatini 00

 

April 3rd: Spine motility-1

                        Fisher 98 and Dunaevsky 99

                        Lendvai 00

                        Yuste and Bonhoeffer, Neuron 2002

 

April 10th: Spine motility-2

                        Majewska 00b

                        Maletic and Engert 99

                        Wong 2000

 

April 17th: Spines and LTP

                        Fivkova

                        Petersen and Hopfield

                        Yuste and Bonhoeffer, ARN 2001

 

April 24th: Spine function

                        Swindale 81

                        Shepherd, Koch

                        Yuste and Majewska, TN 2001

 

May 1^st: last class, Open discussion: the function of spines

 

May 8^th: Exams due