TEXTS:

There are no assigned texts for this section. To review general information, you might look at (the first and last may be the most useful):

1. A. J. F. Griffiths, J. H. Miller, D. T. Suzuki, R. C. Lewontin, and W. M. Gelbart, An Introduction to Genetic Analysis, 7th ed., Freeman, 2000.

2. A. H. Sturtevant and G. W. Beadle, An Introduction to Genetics, Dover Press, 1962

3. F. J. Ayala and J. A. Kiger, Jr., Modern Genetics, 2nd ed., Benjamin Cummins, 1984

4. M. W. Strickberger, Genetics, 3rd edition, Macmillan Publishing Company, 1985.

5. L. H. Hartwell, L. Hood, M. L. Goldberg. A. E. Reynolds, L. M. Silver, and R. C. Veres, Genetics: From Genes to Genomes, McGraw Hill 2000

JOURNALS:

The major journal for transmission genetics is Genetics. Each issue lists articles by organism (viruses to humans to populations) and usually contains one "Perspectives" article (these are usually historical notes). Genetics articles can also be found in Science, Nature, Cell, EMBO Journal, Molecular and General Genetics, Wilhelm Roux's Archives of Developmental Biology, and Nature Genetics. The best introduction to the various topics in genetics is found in various review journals including Annual Review of Genetics, Trends in Genetics, and Current Opinion in Genetics and Development (and Minireviews and News-and-Views articles in Cell, etc.).

WEB SITES:

Mendel Web: http://www-hpcc.astro.washington.edu/mirrors/MendelWeb/

Virtual Fly Lab: http://vflylab.calstatela.edu/edesktop/VirtApps/VflyLab/IntroVflyLab.html

Microbial Genetics Problems Co-op: http://www.life.uiuc.edu/micro/316resources/

Virtual Library - Genetics: http://www.ornl.gov/TechResources/Human_Genome/genetics.html

COURSE SCHEDULE:

Sept. 5: Short Presentations: Genetic Terms

Sept. 6: Transmission Genetics

S. Brenner (1974) The genetics of Caenorhabditis elegans. Genetics 77: 71-94.

M. Chalfie (1997) Is the traditional way of teaching three-factor mapping sufficient? Trends Genetics 13: 94-95.



Sept. 7: Review of Brenner paper

Sept. 8: Gene/protein relationships I.

I. Herskowitz (1987) Functional inactivation of genes by dominant negative mutations. Nature 329: 219-222.

P.J. Rosenfeld, G.S. Cowley, T.L. McGee, M.A. Sandberg, E.L. Berson, and T.P. Dryja (1992) A Null mutation in the rhodopsin gene causes rod photoreceptor dysfunction and autosomal recessive retinitis pigmentosa. Nature Genetics 1: 209-213.

Sept. 12: Gene/protein relationships II.

J.H. Thomas (1993) Thinking about genetic redundancy. Trends in Genetics 9: 395-398.

Sept. 13: Suppressors/Enhancers

M.A. Simon, D.D. Bowtell, G.S. Dodson, T.R. Laverty, and G.M. Rubin (1991) Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase. Cell 67: 701-716.

Sept. 14: Epistasis

L. Avery and S. Wasserman (1992) Ordering gene function: the interpretation of epistasis in regulatory hierarchies. Trends Genetics 8: 312-316.

Sept. 15: Presentations 1, 2, and 3

P1. A. Bejsovec and P. Anderson (1990) Function of the myosin ATP and actin binding sites are required for C. elegans thick filament assembly. Cell 60: 133-140.

P2. J. Ahringer and J. Kimble (1991) Control of the sperm-oocyte switch in Caenorhabditis elegans hermaphrodites by the fem-3 3' untranslated region. Nature 349:346-348.

P3. B. M. Cali and P. Anderson (1998) mRNA surveillance mitigates genetic dominance in Caenorhabditis elegans. Mol. Gen. Genet. 260: 176-184.

Sept. 19: Mosaics: Expression Patterns

P.A. Lawrence and S.M. Green (1979) Cell lineage in the developing retina of Drosophila. Develop. Biol. 71: 142-152.

Sept. 20: Using Transposons

E. Bier et al. (1989) Searching for Pattern and Mutation in the Drosophila genome with a P-lacZ vector. Genes & Develop. 3: 1273-1287.

Sept. 21: Presentations 4 and 5

P4. K.G. Golic (1991) Site-specific recombination between homologous chromosomes in Drosophila. Science 252: 958-961.

P5. C.B. Phelps and A.H. Brand (1998) Ectopic gene expression in Drosophila using GAL4 system. Methods 14:367-379.

Sept. 22: Presentations 6 and 7

P6. A. Fire, S. Xu, M. K. Montgomery, S. A. Kostas, S. E. Driver, and C. C. Mello (1998) Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391: 806 - 811.

P7. Y.S. Rong and K.G. Golic (2000) Gene Targeting by homologous recombination in Drosophila. Science 288: 2013-2018.

Sept. 26: Genomes

G.R. Rubin et al. (2000) Comparative genomics of the eukaryotes. Science 287: 2204-2215.

Sept.28: Mouse Genetics (Lili Yamasaki)

Sept. 27: Somatic Cell Genetics (Larry Chasin)

Sept. 29: Exam

Reading for the exam:

C. Nüsslein-Volhard and E. Wieshaus (1980) Mutations affecting segment number and polarity. Nature 287: 795-801.