Lectures: Tu/Th 4:10-5:25;
Location: 501 Schermerhorn
Graduate students: Tuesday Fairchild 1000 TA: Joe Schumacher
Group I Tuesday Fairchild 700 TA: Heidi Smith
Group II Tuesday Fairchild 900 TA: Cate Jensen
Group III Wednesday Fairchild 900 TA: Melissa Walker
Group IV Wednesday Fairchild 900 TA: Feifan Zhang
Group V Thursday Fairchild 900 TA: Sara Morrison
Jian Yang, firstname.lastname@example.org
Joe Schumacher email@example.com
Cate Jensen firstname.lastname@example.org
Melissa Walker email@example.com
Feifan Zhang firstname.lastname@example.org
Heidi Smith email@example.com
Sara Morrison firstname.lastname@example.org
Required Text: Neuroscience, 4th ed., 2008, Purves et al.
From Neuron to Brain, 4th ed., 2001, Nicholls et al.
Principles of Neural Science, 4th ed., 2000.
Eric Kandel, James Schwartz and Thomas Jessell
Recitations: A strong emphasis is placed on readings from the primary literature, which will be discussed in weekly recitations. Students will read and discuss in depth selected research papers. Attendance of the recitations is mandatory and active participation will count in the final grade. Materials discussed in the recitations will be included in the exams.
Class Attendance: Attendance is not taken, however material will be presented in lectures that is not available in the text and which will appear on examinations
Exams and Grading: Exams and Grading: Three exams and a final examination are given. Each exam will cover material since the previous exam. The final examination is entirely on papers from the primary literature. The lowest grade of the three periodic exams will be dropped (students may choose to take only two tests). The remaining exams will each contribute 30% towards the semester grade; the final will contribute 35% and is required. 5% will come from recitation attendance and participation. No make-up exams will be allowed except in cases of serious illness or personal crisis and the student is required to present a letter from the undergraduate dean as well as other supporting evidence (such as doctor’s notes, airline tickets etc.).
Sept. 2: Lecture 1. Introduction, Cell Biology of the Neuron
Sept. 4: Lecture 2. Ionic Basis of the Resting Membrane Potential
Sept. 9: Lecture 3. Ion Channels
Sept. 11: Lecture 4. Ion Channels
Sept. 16: Lecture 5. Transporters
(Chapter 4 and slides)
Sept. 18: Lecture 6. Passive Electrical Properties of the Neuron
Sept. 23: Lecture 7. Ionic Basis of the Action Potential
(Chapter 2, 3)
Sept. 25: Lecture 8. Generation and Propagation of Action Potentials
Sept 30: Lecture 9. Synaptic Transmission: Overview, Neuromuscular Junction
Oct. 2: EXAM I (Lectures 1-8, Recitations 1-3)
Oct. 7. Lecture 10. Synaptic Transmission: Neuromuscular Junction, CNS
(Chapter 5, 6)
Oct. 9. Lecture 11. Synaptic Transmission: CNS
(Chapter 5, 6)
Oct. 14. Lecture 12. Synaptic Transmission: Slow Synapses
(Chapter 5, 7)
Oct. 16. Lecture 13. Presynaptic Mechanisms: Transmitter Release
Oct. 28. Lecture 14. Synaptic Plasticity
Oct. 30. Lecture 15. Biochemistry of Neurotransmitters
Recitation 6: Kopec et al., “Glutamate Receptor
Exocytosis and Spine Enlargement
during Chemically Induced Long-Term Potentiation”. Journal of Neuroscience 26, 2000 –2009 (2006).
Part III: Sensory Physiology
Nov. 4. Off (election day)
Nov. 6. EXAM II (Lectures 9-15, recitations 4-6)
Nov. 11. Lecture 16. Introduction: Coding of Sensory Signals
Phototransduction and Color Vision
Nov. 13. Lecture 17. Phototransduction and Color Vision
Recitation 7: Palczewski,
K. et al. “
Nov. 18. Lecture 18. Mechanotransduction in the Ear
Nov. 20. Lecture 19. Taste
(Chapter 15) and reading
Recitation 8: Zheng J. et al. “Prestin is the
motor protein of cochlear outer hair cells.”
Nature 2000 May 11;405 (6783):149-55.
Nov. 25 Lecture 20. Olfaction (Chapter 15) and reading
Nov. 27 Off (Thanksgiving)
Recitation 9: hang, X. and S. Firestein (2002). "The olfactory receptor gene superfamily of the mouse." Nat Neurosci 5 (2): 124-33.
Dec.2. Lecture 21. Pain
Dec. 4. EXAM III (Lectures 16-21, recitations 8-10)
Dec. 16. Final exam
The final exam will consist of three sets of questions on selected research articles. It is suggested that you read and analyze these papers prior to the exam, since the exam will be closed-book; i.e. you CANNOT look at the articles, notes or textbook during the exam. You may discuss these papers with other students, but not with the instructors or the TAs.