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| FACULTY BIOGRAPHY |
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| Alexander Tzagoloff |
| Alan H Kempner Professor |
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| Web companion to the paper: "SIT4 Regulation of Respiration in S. cerevisiae"
Propagation of mitochondria depends on the expression of a small number of mitochondrial genes and a much larger pool of genetic information resident in nuclear DNA. Current estimates suggest that in the budding yeast Saccharomyces cerevisiae, close to 400 nuclear genes (referred to as PET genes) encode proteins with functions directly relevant to the maintenance of respiring mitochondria. While the functions of the mitochondrial gene products are well understood, the same cannot be said of the nuclear counterparts. An unexpectedly large proportion of PET genes have turned out to selectively affect the synthesis of individual respiratory complexes such as cytochrome oxidase and the proton translocating ATPase complex. In addition to coding for known subunit polypeptides of these heteroligomeric enzymes, PET genes govern processing of mitochondrial pre-mRNAs, translation of the mature mRNAs, and a host of post- translational events crucial for the production of the final active complexes. The functions of nuclear gene products involved in promoting late steps in assembly of the respiratory chain complexes, ensuing translation, import, and membrane insertion of all the constituents are the main focus of ongoing studies in our laboratory.
MedLine Listing of Dr. Tzagoloff's Publications |
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Representative Recent Publications
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- Zeng, X., Hourset, A., and Tzagoloff, A. (2007) The Saccharomyces cerevisiae ATP22 gene codes for the mitochondrial ATPase subunit 6 specific translation factor. 175: 55-63.
- Zeng, X., Neupert, W., and Tzagoloff, A. (2007) The metalloprotease encoded by ATP23 has a dual function in processing and assembly of subunit 6 of mitochondrial ATPase. Mol. Biol. Cell 18: 617-626.
- Zambrano, A., Fontanesi, F., Solans, A., Leite de Oliveira, R., Fox, T. D., Tzagoloff, A., and Barrientos, A. (2007) Aberrant translation of cytochrome c oxidase subunit 1 mRNA species in the absence of Mss51p in the yeast Saccharomyces Cerevisiae. Mol. Biol. Cell. 18: 523-535.
- Briere, J.-J. and Tzagoloff, A. (2007) The scoop on sco. Mol. Cell 25: 126-128..
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