Dr. Alice Heicklen

FACULTY

RESEARCH

Ph.D. PROGRAM

M.A. BIOTECHNOLOGY

UNDERGRADUATE

COURSES



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Alice Heicklen

Lecturer

Post Doctorate/Instructor- The Albert Einstein College of Medicine, Sept. 2000-2004, NIH Cardiovascular fellowship /American Heart Association Scientific Development Fellowship. Aberrant heart development and maintenance are major causes of miscarriages and heart failure. I have created Zebrafish lines using GATA-4 and GATA-6 regulatory regions to reveal in real time the role of these GATA factors in heart development and disease.

EDUCATION

Phd., Weizmann Institute of Science, Israel, July 2000, Transcriptional regulationof the microtubule associated protein, tau and its deregulation in Alzheimer's disease. Outstanding student award.
Advisor: Dr. Irith Ginzburg

M.S. Tel Aviv University, Israel, March 1991, Intermodal compensation in the neonatally enucleated Syrian hamster. Honors

B.A. Penn State University, May 1988. Honors

Representative Recent Publications

Heicklen-Klein A, Mc Reynolds L J and Evans T. (2005) Using the zebrafish model to study GATA transcription factors. Sem. Cell. Dev. Biol. 16: 95-106.
Heicklen-Klein A and Evans T. (2004) T-Box binding sites are required for activity of a cardiac GATA-4 enhancer Dev. Biol 267(2): 490-504.
Izraeli R, Koay G, lamish M, Heicklen-Klein A, Heffner H. E, Heffner R. S and Wollberg Z. (2002) Cross-modal neuroplasticity in blind hamsters: structure, electrophysiology and behavior. Eur. J. Neurosci. 15: 693-712.
Heicklen-Klein A and Ginzburg I. (2000) Tau promoter confers neuronal specificity and binds Sp1 and AP-2. J. Neurochem. 75(4): 1408-1418.
Heicklen-Klein A, Aronov S and Ginzburg I. (2000) Tau promoter confers neuronally differentiated P19 cells Mol. Brain Res. 874(1): 1-9.
Sadot E, Heicklen-Klein A, Barg J, Lazarovici P and Ginzburg I. (1996) Identification of a tau promoter region mediating tissue-specific-regulated expression in PC12 cells J. Mol. Biol. 256: 805-812.
Gur S, Ron S and Heicklen-Klein A. (1994) Objective evaluation of visual fatigue in VDU workers Occup. Med. 44: 201-204.
Gur S, Ron S and Heicklen-Klein A. (1992) The need for visual impairment evaluation in VDU workers Arch. Science Lav. 8: 125-129.





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