 |
| |  |
| | | |
|
Research Highlights
|
|
| Combined deficiency of p50 and cRel in CD4+ T cells reveals an essential requirement for nuclear factor kappaB in regulating mature T cell survival and in vivo function. |
|
| Amer Beg
()
|
|
|  Protein components produced by certain bacteria can induce lethal shock in humans. One of the most important types of these proteins is Staphylococcal enterotoxin B (SEB). This "superantigen" induces polyclonal activation and proliferation of T lymphocytes, resulting in large systemic infusion of pro-inflammatory cytokines. To understand possible mechanisms responsible for SEB-induced T cell proliferation, we tested the potential role of NF-kB transcription factors in this process. As shown, SEB induces strong proliferation of wild-type but not NF-kB deficient T cells. These results therefore indicate that NF-kB inhibition may be efficacious in suppressing SEB induced shock in humans.
view article |
|
