James L. Manley - Publications (since 1995)

 122. Colgan, J. and Manley, J.L. (1995). Cooperation between core promoter elements influences transcriptional activity in vivo. Proc. Natl. Acad. Sci. U.S.A. 92, 1955-1959.

 123. Norris, J. and Manley, J.L. (1995). Regulation of dorsal in cultured cells by Toll and tube: tube function involves a novel mechanism. Genes Dev. 9, 358-369.

 124. Manley, J.L. (1995). A complex protein assembly catalyzes polyadenylation of mRNA precursors. Cur. Op. Gen. Dev. 5, 222-228.

 125. Colgan, J., Ashali, H. and Manley, J.L. (1995). Direct interactions between a glutamine-rich activator and the N-terminus of TFIIB mediate transcriptional activation in vivo. Mol. Cell. Biol. 15, 2311-2320.

126. Sun, J.S. and Manley, J.L. (1995). A novel U2-U6 snRNA structure is necessary for mammalian mRNA splicing. Genes Dev. 9, 843-854.

 127. UmM., Li, C. and Manley, J.L. (1995). The transcriptional repressor Even-skipped interacts directly with the TATA binding protein. Mol. Cell. Biol. 15, 5007-5016.

 128. Tacke, R. and Manley, J.L. (1995). The human splicing factors ASF/SF2 and SC35 possess different, functionally significant RNA binding specificities. EMBO J. 14, 3540-3551.

 129. Manley, J.L. (1995). mRNA polyadenylation: A universal modification. (Commentary) Proc. Natl. Acad. Sci. U.S.A. 92, 1800-1801.

 130. Jamison, S.F., Zelano, A., Pasman, Z., Wang, J., Will, C., Lhrman, R., Manley, J.L. and Garcia-Blanco, M.A. (1995). U1 snRNP-ASF/SF2 interaction and 5' splice site recognition: Characterization of required elements. Nuc. Acids Res. 23, 3260 -3267.

 131. Bermingham, J.R., Arden, K.C., Naumova, A.K., Sapienza, C., Viaus, C.S., Fu, X.-D., Kohtz, J., Manley, J.L. and Rosenfeld, M.G. (1995). Chromosomal localization of mouse and human genes encoding ASF/SF2 (Sfrs1) and SC-35 (Sfrs2). Genomics 29 , 70-79.

 132. Wang, J. and Manley, J.L. (1995). Overexpression of the SR proteins ASF/SF2 and SC35 influences alternative splicing in vivo in diverse ways. RNA 1, 335-346.

 133. Murthy, K.G.K., and Manley, J.L. (1995). The 160kD subunit of human cleavage- polyadenylation specificity factor coordinates pre-mRNA 3' end formation. Genes Dev. 9, 2672-2683.

 134. Lutz, C.S., Murthy, K.G.K., Schek, N., O'Connor, J.P., Manley, J.L. and Alwine, J.C. (1996). Interaction between the U1 snRNP-A protein and the 160kD subunit of cleavage-polyadenylation specificity factor increases polyadenylation efficiency in vitro. Genes Dev. 10, 325-337.

135. Colwill, K., Jacob, S., Andrews, B., Prasad, J., Manley, J.L., Pawson, T., Bell, J.C. and Duncan, P.I. (1996). The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intracellular distribution. EMBO J. 15, 265-275.

 136. Manley, J.L., Um, M., Li, C. and Ashali, H. (1996). Mechanisms of transcriptional activation and repression can both involve TFIID. Phil. Trans. Roy. Soc., Series B 351, 517-526.

 137. Zhao, W.Q. and Manley, J.L. (1996). Complex alternative RNA processing generates an unexpected diversity of poly(A) polymerase isoforms. Mol. Cell. Biol. 16, 2378- 2386.

 138. Norris, J. and Manley, J.L. (1996). Functional interactions between the pelle kinase, Toll receptor and tube suggest a mechanism for activation of Dorsal. Genes Dev. 10, 862-872.

 139. Farmer, G., Colgan, J., Nakatani, T., Manley, J.L. and Prives, C. (1996). A functional interaction between p53, TBP and TAFs in vivo. Mol. Cell. Biol. 16, 4295-4304.

 140. Manley, J.L. and Tacke, R. (1996). SR proteins and splicing control. Genes Dev. 10, 1569-1579.

 141. Farmer, G., Friedlander, P., Colgan, J., Manley, J.L. and Prives, C. (1996). Transcriptional repression by p53 involves interactions distinct from those with the TATA-box binding protein. Nucl. Acids Res. 24, 4281-4288.

 142. Colgan, D.F., Murthy, K.G.K., Prives, C. and Manley, J.L. (1996). Cell-cycle related regulation of poly(A) polymerase by phosphorylation. Nature 384, 292-285.

 143. Wang, J., Takagaki, Y. and Manley, J.L. (1996). Targeted disruption of an essential vertebrate gene: ASF/SF2 is required for cell viability. Genes Dev. 10, 2588-2599.

 144. Takagaki, Y., Seipelt, R.L., Peterson, M.L. and Manley, J.L. (1996). The polyadenylation factor CstF-64 regulates IgM pre-mRNA processing during B cell differentiation. Cell 87, 941-952.

 145. Manley, J.L and Takagaki, Y. (1996). The end of the message - another link between yeast and mammals. (Perspective) Science 274, 1481-1482.

 146. Tacke, R., Chen, Y. and Manley, J.L. (1997). Sequence-specific RNA binding by an SR protein requires RS domain phosphorylation: Creation of an SRp40-specific splicing enhancer. Proc. Natl. Acad. Sci. USA 94, 1148-1153.

 147. Xiao, S.-H. and Manley, J.L. (1997). Phosphorylation of the ASF/SF2 RS domain affects both protein-protein and protein-RNA interactions and is necessary for splicing. Genes Dev. 11, 334-344.

 148. Wang, J. and Manley, J.L. (1997). Regulation of splicing in metazoa. Cur. Op. Gen. Dev. 7, 205-211.

 149. Sun, J.S. and Manley, J.L. (1997). The human U6 snRNA intramolecular helix: Structural constraints and lack of sequence specificity. RNA 3, 514-526.

 150. Dantonel, J.-C., Murthy, K.G.K., Manley, J.L. and Tora, L. (1997). CPSF links transcription and mRNA 3' end formation. Nature 389, 399-402.

 151. Takagaki, Y. and Manley, J.L. (1997). RNA recognition by the human polyadenylation factor CstF. Mol. Cell. Biol. 17, 3907-3914.

 152. Hirose, Y. and Manley, J.L. (1997). Creatine phosphate, not ATP, is required for 3'- end cleavage of mammalian pre-mRNA in vitro. J. Biol. Chem. 272, 29636-29642.

153. Colgan, D.F. and Manley, J.L. (1997). Mechanism and regulation of pre-mRNA polyadenylation. Genes Dev. 11, 2755-2766.

 154. Colgan, D.F., Zhao, W.Q., Murthy, K.G.K., Prives, C. and Manley, J.L. (1998). p34cdc2/cyclin B phosphorylates poly(A) polymerase on multiple consensus and nonconsensus sites. EMBO J. 17, 1053-1062.

155. Jayaraman, L., Moorthy, N. C., Murthy, K.G.K.,, Manley, J.L., Bustin, M. and Prives, C. (1998). High mobility group protein-1 (HMG-1) is a unique activator of p53. Genes Dev. 12, 462-472.

156. Tacke, R., Tohyama, M., Ogawa, S. and Manley, J.L. (1998). Human Tra2 proteins are sequence-specific activators of pre-mRNA splicing. Cell 93, 139-148.

157. Sun, J.S., Valadkhan, S. and Manley, J.L. (1998). A UV-crosslinkable interaction in human U6 snRNA. RNA 4, 489-497.

158. Wang, J., Xiao, S. and Manley, J.L. (1998). Genetic analysis of the SR protein ASF/SF2: Interchangeability of RS domains and negative control of splicing. Genes Dev. 12, 2222- 2233.

159. Li, C. and Manley, J.L. (1998). Even-skipped represses transcription by binding TBP and blocking the TFIID-TATA box interaction. Mol. Cell. Biol. 18, 3771-3781.

160. Hirose, Y. and Manley, J.L. (1998). RNA polymerase II is an essential mRNA polyadenylation factor. Nature 395, 93-96.

161. Zhao, W.-Q. and Manley, J.L. (1998). Deregulation of poly(A) polymerase interferes with cell growth. Mol. Cell. Biol. 18, 5010-5020.

162. Xiao, S.-H. and Manley, J.L. (1998). Phosphorylation-dephosphorylation differentially affects activities of splicing factor ASF/SF2. EMBO J. 17, 6359-6367.

163. Moreira, A., Takagaki, Y., Backenridge, S., Manley, J.L. and Proudfoot, N.J. (1998). The upstream sequence element in the complement C2 poly(A) signal activates mRNA 3' end formation by two distinct mechanisms. Genes Dev. 12, 2522-2534.

164. Shen, B. and Manley, J.L. (1998). Phosphorylation modulates direct interactions between the Toll receptor, pelle kinase and tube. Development 125, 4719-4728.

165. Takagaki, Y. and Manley, J.L. (1998). Levels of polyadenylation factor CstF-64 control accumulation of IgM heavy chain mRNA and induce other events associated with B cell differentiation. Mol. Cell 2, 761-771.

166. Tacke, R. and Manley, J.L. (1999). Functions of SR and Tra2 proteins in pre-mRNA splicing regulation. Proc. Soc. Exp. Biol. Med. 220, 59-63.

167. Li, C. and Manley, J.L. (1999). Allosteric regulation of Even-skipped repression activity by phosphorylation. Mol. Cell 3, 77-86.

168. Tacke, R. and Manley, J.L. (1999). Determinants of SR protein specificity. Cur. Op. Cell Biol. 11, 358-62.

169. Hirose, Y., Tacke, R. and Manley, J.L. (1999). Phosphorylated RNA polymerase II stimulates pre-mRNA splicing. Genes Dev. 13, 1234-39.

170. Kleiman, F. and Manley, J.L. (1999). Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50. Science 285, 1576-1579.

171. Prasad, J., Sun, J. S., Colwill, K., Pawson, T. and Manley, J.L. (1999). The protein kinase Clk/Sty directly modulates SR protein activity: both hyper- and hypo-phosphorylation inhibit splicing. Mol. Cell Biol. 19, 6991-7000.

172. Takagaki, Y. and Manley, J.L. (2000). Complex protein interactions within the human polyadenylation machinery identify a novel component. Mol. Cell Biol. 20, 1515-1525.

173. Hatton, L.S., Eloranta, J., Figueiredo, L., Takagaki, Y., Manley, J.L., and O'Hare, K. (2000). The Drosophila homologue of the 64 kDa subunit of Cleavage Stimulation Factor interacts with the 77 kDa subunit encoded by the suppressor of forked gene. Nucl. Acids Res. 28, 520-526.

174. Valadkhan, S. and Manley, J.L. (2000). A tertiary interaction detected in a human U2-U6 snRNA complex assembled in vitro resembles a genetically proven interaction in yeast. RNA 6, 206-219.

175. Koffa, M.D., Graham, S.V., Takagaki, Y., Manley, J.L., and Clements, B. (2000). The human papillomavirus type 16 negative regulatory RNA element interacts with three proteins that act at different post-transcriptional levels. Proc. Nat. Acad. Sci. USA 97,4677-4682.

176. Chen, Z. and Manley, J.L. (2000). Robust mRNA transcription in chicken DT40 cells depleted of TAFII31 suggests both functional degeneracy and evolutionary divergence. Mol. Cell. Biol. 20, 5064-5076.

177. Bond, G.L., Prives, C. and Manley, J.L. (2000). Poly(A) polymerase phosphorylation is dependent on novel interactions with cyclins. Mol. Cell. Biol. 20, 5310-5320.

178. Hirose, Y. and Manley, J.L. (2000). RNA polymerase II and the integration of nuclear events. Genes Dev. 14, 1415-1429.

179. Shatkin, A.J. and Manley, J.L. (2000). The ends of the affair: Capping and polyadenylation. Nat. Struct. Biol. 7, 838-42.

180. Mendez, R., Murthy, K.G.K., Ryan, K., Manley, J.L. and Richter, J.D. (2000). Phosphorylation of CPEB by Eg2 mediates the recruitment of CPSF into an active cytoplasmic polyadenylation complex. Mol. Cell 6, 1253-1259.

181. Xu, Y., Tao, X., Shen, B., Horng, T., Medzhitov, R., Manley, J.L. and Tong, L. (2000). Structural basis for signal transduction by the Toll/interleukin-1 receptor (TIR) domains. Nature 408, 111-115.

182. Um, M. and Manley, J.L. (2000). The Drosophila TATA binding protein contain a strong but masked activation domain. Gene Expression 9, 123-132.

183. Um, M. and Manley, J.L. (2001). Heterozygous disruption of the TATA binding protein gene in DT40 cells causes multiple growth defects, including reduced cdc25B phosphatase expression and delayed mitotis. Mol. Cell. Biol. 21, 2435-2448.

184. Kleiman, F.E. and Manley, J.L. (2001). The Bard1-CstF-50 interaction links mRNA 3' end formation to DNA damage and tumor suppression. Cell 104, 743-753.

185. Calvo, O. and Manley, J.L. (2001). Evolutionarily conserved interaction between CstF-64 and PC4 links transcription, polyadenylation and termination. Mol. Cell 7, 1013-1023.

186. Shen, B., Liu, H., Skolnik, E.Y. and Manley, J.L. (2001). Physical and functional interactions between Drosophila TRAF2 and pelle kinase contribute to dorsal activation. Proc. Natl. Acad. Sci. USA 98, 8596-8601..

187. Luo, C., Shen, B., Manley, J.L. and Zheng, L. (2001). Tehao functions in the Toll pathway in Drosophila melanogaster: Possible roles in development and innate immunity. Insect Mol. Biol. 10, 457-464.

188. Topalian, S.L., Kaneko, S., Gonzales, M.I., Bond, G.L., Ward, Y. and Manley, J.L. (2001). Identification and functional characterization of Neo-poly(A) polymerase, an RNA processing enzyme overexpressed in human tumors. Mol. Cell. Biol. 21, 5614- 5623.

189. Valadkhan, S. and Manley, J.L. (2001). Splicing-related catalysis by protein-free snRNAs, Nature 413, 701 - 707 .

190. Prives, C. and Manley, J.L. (2001). Why is p53 acetylated? Cell 107, 815818.

191. Ryan, K., Murthy, K.G.K., Kaneko, S. and Manley, J.L. (2002). Requirements of the RNA polymerase II C-terminal domain for reconstituting pre-mRNA 3' cleavage. Mol. Cell. Biol. 22, 1684-1692.

192. Lemaire, R., Prasad, J., Kashima, T., Gustafson, J., Manley, J.L. and Lafyatis, R. (2002). Stability of a PKCI-1-related mRNA is controlled by the splicing factor ASF/SF2: A novel function for SR proteins. Genes Dev. 16, 594-607.

193. Shen, B. and Manley, J.L. (2002). Pelle kinase is activated by autophosphorylation during Toll signaling in Drosophila. Development 129, 1925-1933.

194. Chen, A., Kleiman, F.E., Manley, J.L., Ouchi, T., and Pan, Z.Q. (2002). Auto-ubiquitination of the BRCA1/BARD1 RING ubiquitin ligase. J. Biol. Chem. 277, 22085-22092.

195. Valadkhan, S. and Manley, J.L. (2002). Intrinsic metal binding by a spliceosomal RNA. (News and Views) Nat. Struct. Biol. 9, 498-499.

196. Shin, C. and Manley, J.L. (2002). The SR protein SRp38 represses splicing in M-phase cells. Cell 111, 407-417.

197. Manley, J.L. (2002). Nuclear coupling: RNA processing reaches back to transcription. (News and Views) Nat. Struct. Biol. 9, 790-91.

198. Shin, C. and Manley, J.L. (2003). Role of alternative splicing during the cell cycle and programmed cell death. In Handbook of Cell Signaling, eds. Bradshaw, R.A. and Dennis, E. (Academic Press, San Diego, CA), in press.

199. Portal, D. et al. (2003). Trypanosoma cruzi TcSRPK, the first protozoan member of the SRPK family, is biochemically and functionally conserved with metazoan SR protein-specific kinases. Mol. Biochem. Parasitol. 127, 9-21.

200. Schwerk, C., Prasad, J., Degenhardt, K., Erdjument-Bromage, H., Tempst, P., Kidd, V.J., White, E., Manley, J.L., Lahti, J.M. and Reinberg, D. (2003). ASAP, a novel protein complex involved in RNA processing and apoptosis. Mol. Cell. Biol. 23, 2981-2990.

201. Prasad, J. and Manley, J.L. (2003). Regulation and substrate specificity of the SR protein kinase Clk/Sty. Mol. Cell. Biol. 23, 4139-4149.

202. Valadkhan, S. and Manley, J.L. (2003). Characterization of the catalytic activity of U2 and U6 snRNAs. RNA 9, 892-904.

203. Calvo, O. and Manley, J.L. (2003). Strange bedfellows: polyadenylation factors at the promoter. Genes Dev.17, 1321-1327.

204. Kashima, T. and Manley, J.L. (2003). A negative element in SMN2 exon 7 inhibits splicing in Spinal Muscular Atrophy. Nature Genetics 4, 460-463.

205. Chen, Z. and Manley, J.L. (2003). In vivo functional analysis of the histone 3-like TAF9 and a TAF9-related factor, TAF9L. J. Biol. Chem., in press.

206. Chen, Z. and Manley, J.L. (2003). Core promoter elements and TAFs contribute to the diversity of transcriptional activation in vertebrates. Mol. Cell. Biol., in press.

207. Poyurovsky, M., Jacq, X., Ma, C., Karni-Schmidt, O., Parker, P.J., Chalfie, M., Manley, J.L. and Prives, C. (2003) Nucleotide binding by the MDM2 ring domain facilitates ARF-independent MDM2 nucleolar localization. Mol. Cell, in press.