Carol L. Prives - Selected Publications (since 1992)
1. Zambetti, G.P., Bargonetti, Walker, K., Prives, C., A.J. Levine. (1992) Wild-type p53 mediates positive regulation of gene expression through a specific DNA sequence element. Genes & Dev., 6: 1143-1152.
66. Farmer, G., Bargonetti, J., Zhu, H. Friedman, P, Prywes, R. and C. Prives.(1992) Wild type p53 activates transcription in vitro. Nature 358: 83-86.
2. Bargonetti, J., Reynisdottir, I. Friedman, P. and Prives, C. (1992) Wild-type p53 site specific binding to cellular DNA is regulated by SV40 T antigen and mutant p53. Genes & Dev. 6: 1886-1898.
68. Reynisdottir, I and Prives., C. (1992) Two conditional tsA mutant T antigens display marked differences in thermal inactivation. J. Virol. 66: 6517-6526.
3. Friedman, P., E. Wang and C. Prives. (1992) Murine p53 inhibits the function but not the formation of SV40 large T antigen oligomers in vitro. Chromosoma 102: S60-S66.
4. Friedman, P.F., Chen, X., Bargonetti, J., and C. Prives. Immunopurified p53 protein is an unusually shaped tetramer that binds directly to DNA. 1993. Proc. Natl. Acad. Sci. U.S.A. 90: 3319-3323.
72. Prives, C., (1993) Doing the right thing: Feedback control and p53. Current Opinion in Cell Biology. 5: 214-218.
5. Prives, C., and Manfredi, J.J. (1993) p53 in Tiberias: Review of Sixth International p53 Meeting. Genes & Dev.7: 525-534.
74. Manfredi, J.J. and Prives, C. (1993) Primary rat cells expressing a hybrid polyomavirus-simian virus 40 (SV40) large T antigen have altered growth properties. J. Virol. 67: 4750-4759.
6. Wang, E. Bhattachayra, S. and C. Prives. (1993) The replication function of polyoma large T antigen is regulated by phosphorylation. J. Virol. 67: 6788-6796.
76. Chen, X., H. Zhu., G. Farmer, R. Prywes and C. Prives. (1993) p53 and TATA binding protein cooperate to bind to DNA. Genes & Dev. 7: 1837-1849.
7. Reynisdottir,I., H. E. Lorimer, P.N. Friedman, E. H. Wang and C. Prives (1993). Phosphorylation and active ATP hydrolysis are not required for SV40 T antigen hexamer formation. J. Biol. Chem. 268: 24647-24654.
78. Bargonetti, J., J. Manfredi, X. Chen, D. Marshak and C. Prives. (1993). A proteolytic fragment of wild-type but not mutant p53 spanning the central conserved portion of the protein contains the sequence specific DNA binding domain. Genes & Dev.7: 2565-2574.
8. Moses, K. and Prives, C. (1994) A unique subpopulation of DNA polymerase interacts with polyoma T antigen and stimulates DNA replication. Mol. Cell. Biol.14: 2767-2776.
80. Manfredi, J.J. and Prives, C. Review: Simian virus 40 large T antigen contains multiple transforming regions. Biochim Biophys Acta 1198: 65-83 (1994).
9. Prives, C. 1994 How Loops, β sheets and α Helices help us to understand p53. Cell. 78: 1-4.
Prives, C., Bargonetti, J., Farmer, G., Ferrari,
E., Friedlander, P., Jayaraman, L., Pavletich, N, and U. Hubscher. 1994. The
DNA binding properties of the p53 tumor suppressor protein.
83. Wang, Y., Farmer, G., Soussi, T., and C. Prives. Xenopus laevis p53 protein: sequence specific DNA binding, transcriptional regulation and oligomerization are conserved in evolution. (1995) Oncogene 10: 779-784 .
11. Truant, R., Antunovic, J., Greenblatt, J., Prives, C., and Cromlish, J. A. Direct interaction of the Hepatitus B Virus HBx protein with p53 leads to inhibition by HBx of p53 response element-directed transactivation. (1995) J. Virol. 69: 1851-1859.
A., Stadlbauer, F., Guarino,
12. Wang, Y. and C. Prives. Increased and Altered DNA Binding of Human p53 by S and G2/M but not G1 Cyclin Dependent Kinases (1995) Nature 376: 88-91.
13. Jayaraman, L. and C. Prives. (1995) Activation of p53 Sequence-specific DNA Binding by Short Single Strands of DNA Requires the p53 C-terminus. Cell 81: 1021-1029
88. Chen, X., Bargonetti, J. and C. Prives. (1995) p53, through p21 (WAF1/CIP1) Induces Cyclin D1 Synthesis. Cancer Research 55: 4257-4263.
89. Miller, S., Farmer, G. and C. Prives. (1995) p53 Inhibits DNA Replication In Vitro in a DNA-Binding-Dependent Manner. (1995) Mol. Cell. Biol. 15: 6554-6560.
14. Bhattacharyya, S., Lorimer, H.E. and C. Prives. (1995) Murine Polyomavirus and Simian Virus 40 Large T Antigens Produce Different Structural Alterations in Viral Origin DNA. J. Virol. 69: 7579-7585.
91. Ko, L. and C. Prives. (1996) p53: Puzzle and Paradigm. Genes & Dev.10: 1054-1072.
15. Friedlander, P., Y. Legros, T. Soussi, and C. Prives. (1996) Regulation of mutant p53 temperature sensitive DNA binding. J. Biol. Chem. 271: 25468-25478.
93. Farmer, G. J. Colgan, T. Nakatani, J. Manley and C. Prives. (1996) Functional interactions between p53 and TFIID in vivo. Mol. Cell. Biol. 16: 4295-4304.
16. Farmer, G., Friedlander, P., Colgan, J., Manley, J.L. and C. Prives (1996) Transcriptional repression by p53 involves molecular interactions distinct from those with the TATA-box binding protein. Nucleic Acids Research 24: 4281-4288.
17. Friedlander, P. Y. Haupt, Prives, C. and M. Oren. (1996) A mutant p53 that discriminates between p53 responsive genes cannot induce apoptosis. Mol Cell Biol. 16: 4961-4971.
18. Chen, X., Ko, L., Jayaraman, L. and C. Prives. 1996. p53 levels, functional domains and DNA damage determine the extent of the apoptotic response of tumor cells. Genes & Dev.10: 2438-2451.
19. Okamoto, K., Kamibayashi, C., Serrano, M., Prives, C., Mumby, M.C. and Beach, D. 1996. p53-dependent association between cyclin G and the B' subunit of protein phosphatase 2A. Mol. Cell Biol.16: 6593-6602.
20. Foukal, D.H., Murthy, K.G.K., Raabe, T.,Prives, C. and Manley, J.L. 1996. Repression of poly(A) polymerase by p34cdc2/cyclin B phosphorylation. Nature.384: 282-285.
21. Oren, M. and C. Prives. 1996. p53: upstream, downstream and off stream. Review of the 8th p53 workshop (Dundee July 5-9 1996). BBA Reviews on Cancer. 1288: R13-19 (1996).
22. Jayaraman, L., Murthy, K. G. K., Curran, T., Xanthoudakis, S., and C. Prives. 1997 Identification of redox/repair protein Ref-1 as an activator of p53. Genes & Dev.11: 558-570.
23. Miller, S.D., Moses, K., Jayaraman and C. Prives. (1997) Complex formation between p53 and RP-A inhibits the sequence specific DNA binding of p53 and is regulated by single stranded DNA. Mol. Cell. Biol. 17: 2194-2201.
24. Cain, C., Shieh, S-Y, and C. Prives. (1997) Signalling to the C-terminus of p53. in "Oncogenes as Transcriptional Regulators. Volume 2:Cell Cycle Regulators and Chromosomal Translocation" ed. M. Yaniv and J. Ghysdael. Birkhauser Verlag Publishers. p. 63-75.
103. Jayaraman, l. Freulich, E and C. Prives. 1997. Functional dissection of the p53 tumor suppressor protein. Methods in Enzymology. 283: 245-256.
25. Li, H., Bhattacharyya, S., and C. Prives. 1997 Regulation of the replication functions of polyoma large T antigen by S- and G2- phase cyclin dependent kinases. J. Virol. 71: 6469-6485.
26. Shieh, S-Y., M. Ikeda, Y. Taya, and C. Prives. 1997. DNA damage-induced phosphorylation of p53 alleviates inhibition by mdm2. Cell 91: 325-334.
106. Ko, L.J., X. Chen, S-Y Shieh, L. Jayaraman, K. Tamai, Y. Taya, C. Prives and Zhen-Qiang Pan. 1997. p53 is phosphorylated by CDK7/cyclin H in a p36/MAT1 dependent manner. Mol Cell Biol. 17: 7220-7229.
27. Bargonetti, J., Chicas, A., White, D., and C. Prives. 1997. p53 Represses Sp1 DNA p53 DNA binding and HIV-LTR directed transcription. Cell Mol Biol 1997 43: 935-49.
28. Niculescu, A.B. 3rd., Chen, X., Smeets, M., Hengst, L., Prives, C. and S. I. Reed. 1998. Effects of p21 (Cip1/Waf1) at both the G1/S and the G2/M cell cycle transitions: pRB is a critical determinant in blocking DNA replication and in preventing endoreduplication. Mol. Cell Biol. 18: 629-643.
29. Jayaraman, L., K.G.K. Murthy, J. l. Manley, M. Bustin and C. Prives. 1998. Identification of HMG-1 as a unique activator of p53. Genes & Dev. 12: 462-472.
30. Colgan, D.F., Murthy, K.G., Zhao, W. Prives, C. and J. L. Manley. 1998. Inhibition of poly (A) polymerase requires p34cdc2/cyclin B phosphorylation of multiple consensus and non-consensus sites. EMBO J. 17: 1053-1062.
31. DiComo,C.J. and C. Prives. 1998. Human tumor-derived p53 proteins exhibit binding site selectivity and temperature sensitivity for transactivation in a yeast-based assay. Oncogene. 16: 2527-2539.
112. de Stanchina, E., McCurrach, M.E., Zindy, F., S-Y. Sjhieh, Ferbeyre, G., Samuelson, A.V., Prives, C., Roussel, M.F., Sherr, C.J. and S. Lowe. (1998). E1a signalling to p53 involves the p19ARF tumor suppressor. Genes. Dev. 12: 2434-2443.
32. Banin, S., Moyal, L., Khostravi, R., Shieh, S-Y., Taya, Y., Anderson, C.W., Chessa, L., Smorodinsky, N.I., Prives, C., Shiloh, Y. and Ziv, Y. (1998) Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science. 281: 1674-1677.
114. Jayaraman L. and Prives, C. Covalent and non-covalent modifiers of the p53 protein. (1998) Cell and Molecular Life Sciences. Ed. Moshe Oren, 55:76-87.
33. Prives. C. (1998) Signalling to p53: breaking the p53:Mdm2 circuit. Cell.95: 5-8.
116. Di Como, C.J., Gaiddon, C. and C. Prives. 1999. p73 function is inhibited by tumor-derived p53 mutants in mammalian cells. Mol Cell Biol. 19: 1438-1499.
34. Pridhod'ko, G.G., Wang, Y., Freulich, E., Prives, C. and L. K. Miller. 1999. Baculovirus p33 binds human p53 and enhances p53-mediated apoptosis. J. Virol. 73: 1227-1234.
35. Tibbetts R.S., Brumbaugh, K.M., Williams, J.M., Sarkaria, J.N., Cliby, W.A., Shieh,S-Y, Taya ,Y., Prives, C., and Abraham, R.T. 1999. A role for ATR in the DNA damage-induced phosphorylation of p53. Genes Dev. 13: 152-157
36. van Lookeren Campagne, M., Okamoto, K., Prives, C., and Gill, R. 1999. Developmental expression and co-localization of cyclin G1 and the B' subunits of protein phosphatase 2a in neurons. Brain Res. Mol. Brain Res. 64: 1-10.
37. Vassilev, A., Yamauchi, J., Kotani, T., Prives, C., Avantaggiati, M.L., Qin, J., Nakatani, Y.,1999. The 400 kDa subunit of the PCAF histone acetylase complex belongs to the ATM superfamily. Mol Cell 2: 869-877.
121. Prives, C., and Hall, P.A., 1999. The p53 pathway. J. Pathology. 187: 112-126
123. Shieh, S-Y., Taya, Y. and C. Prives. 1999. Oligomerization of p53 is required for DNA-damage-induced phosphorylation at the N-terminus of p53. EMBO J. 18:1815-1823.
124. Okamoto, K. and C. Prives A role of cyclin G in the process of apoptosis. 1999. Oncogene. 18: 4606-4615.
126. White E, and C. Prives 1999. DNA damage enables p73. Nature 399: 734-5
127. Cordon-Cardo, C, and C. Prives. 1999. At the Crossroads of Inflammation and
Tumorigenesis. J. Exp. Med. 190: 1367-1370.
128. Shieh, S-Y., Ahn, J., Tamai, K., Taya, Y., and C. Prives. 2000. The human homologues of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage inducible sites. Genes &. Dev. 14: 289-300.
129. Ollmann, M., Young,L.M., Di Como, C.J. Karim, F., Belvin, M., Roberts, S., Whittaker, K., Demsky, M., Fisher, W.W., Buchman, A., Duyk,G., Friedman, L., Prives, C and C. Kopczynski 2000. Drosophila p53 is a Structural and Functional Homolog of the Tumor Suppressor p53. Cell 101: 91-101.
131. Bond G.L., Prives, C., J. L. Manley 2000. Poly(A) polymerase phosphorylation is dependent on novel interactions with cyclins. Mol Cell Biol 20: 5310-20.
132. Cain, C., Miller, S., Ahn, J and C. Prives 2000. The N-Terminus of p53 Regulates Its Dissociation From DNA. J. Biol. Chem. 275:39944-53.
132. Gottifredi, V., Shieh, S-Y, Taya ,Y., and C. Prives 2001 P53 Accumulates but is Functionally Impaired when DNA Synthesis is Blocked. Proc. Natl. Acad. Sci. U.S.A. 98:1036-1041.
133. Gottifredi, V., Karni-Schmidt, O., Shieh, S-Y., and C. Prives, 2001. P53 down-regulates hCHK1 through p21. Mol. Cell. Biol 21:1066-1076..
135. Gaiddon C, Lokshin M., Ahn J. T. Zhang and Prives C. 2001. A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain. Mol Cell Biol. 21:1874-1887.
137. Gottifredi, V and C. Prives. 2001. P53 and PML: New partners in tumor suppression. Trends Cell Biol. 11: 184-187.
138. Zhang T., and C. Prives. 2001 Cyclin A-CDK phosphorylation regulates Mdm2 protein interactions. 2001 J. Biol. Chem. 276: 29702-10.
139. Gottifredi, V., and C. Prives. 2001 Getting p53 Out of the Nucleus. 2001 Science 292:1851-2.
140. Ahn, J., and C. Prives. 2001 The C-terminus of p53: the more you learn the less you know. Nat Struct Biol. 8: 730-2.
141. Baptiste, N., Friedlander, P., Chen X., and C. Prives. 2001.The pro-domain of p53 is required for cooperation with anti-neoplastic agents to promote apoptosis of tumor cells. Oncogene 21: 9-21.
142. Prives, C. and J.L. Manley. 2001. Why is p53 acetylated? Cell, 107: 815-818
143. Okamoto, K., H. Li., Jensen , M., Zhang, T., Thorgeirsson S., and C. Prives. 2002 Cyclin G Recruits PP2A to Dephosphorylate Mdm2. Molecular Cell. 9: 761-771.
144. Urist, M. and C. Prives. 2002 P53 leans on its siblings. Cancer Cell. May 311-313.
147. Haupt, Y., Robles, A.I., Prives, C and Rotter, V. 2003 Deconstruction of p53 functions and regulation. Oncogene. 21:8223-31.
Gaiddon, G., Lokshin, M, Gross,
149. Ahn, J, Urist, M, and C. Prives. 2003. Questioning the Role of Chk2 in the p53 DNA Damage Response. J. Biol. Chem. 278: 20480-9.
150. Zhou, J. and C. Prives. 2003. Replication of damaged DNA in vitro is blocked by p53. Nucleic Acids Research. 31: 3881-92.
151. Puig, P., Capodieci, P., Drobnjak, M., Verbel, D., Prives, C., Cordon-Cardo, C., and DiComo, C. J. 2003. p73 expresion in Human Normal and Tumor Tissues: Loss of p73 Expression is Associated with Tumor Progression in Bladder Cancer. Clinical Cancer Research. 9:5642-51.
152. Poyurovsky, M., Jacq, X., Ma, C., Karni-Schmidt, O., Parker., P.J., Chalfie, M., Manley, J.L., and C. Prives. 2003. Nucleotide binding by the Mdm2 RING domain facilitates ARF-independent Mdm2 nucleolar localization. Molecular Cell. 12: 875-887.
154. Gottifredi, V.,
155. Baptiste N., and Prives C. p53 in the cytoplasm: a question of overkill? 2004. Cell 116: 487-9.
156. Urist, M. and C. Prives. The lynchpin? Pin1 meets p73. 2004. Cancer Cell. 5: 515-7.
157. Ahn, J., Urist, M. and Prives C., 2004. DNA Repair. 3: 1039-1047.
159. Urist, M., Tanaka, T., Poyurovsky, M.V. and C. Prives. 2004. p73 Induction after DNA Damage is Regulated by Checkpoint Kinases, Chk1 and Chk2. Genes Dev. 18: 3041-3054.
Chuikov, S., Kurash, J. K.,