Carol L. Prives - Selected Publications (since 1992)


1.                    Zambetti, G.P., Bargonetti, Walker, K., Prives, C., A.J. Levine. (1992) Wild-type p53 mediates positive regulation of gene expression through a specific DNA sequence element.  Genes & Dev., 6:  1143-1152.


66.       Farmer, G., Bargonetti, J., Zhu, H. Friedman, P, Prywes, R. and C. Prives.(1992)  Wild type p53 activates transcription in vitro. Nature 358:  83-86. 


2.                    Bargonetti, J., Reynisdottir, I. Friedman, P. and Prives, C. (1992) Wild-type p53 site specific binding to cellular DNA is regulated by SV40 T antigen and mutant p53. Genes & Dev. 6:  1886-1898.


68.       Reynisdottir, I and Prives., C. (1992) Two conditional tsA mutant T antigens display marked differences in thermal inactivation. J. Virol. 66:  6517-6526.


3.                    Friedman, P., E. Wang and C. Prives.  (1992) Murine p53 inhibits the function but not the formation of SV40 large T antigen oligomers in vitro. Chromosoma 102:  S60-S66.


70.       Lorimer, H. E., Ness, S. and Prives, C. (1993) Unusual properties of a replication defective mutant SV40 large T antigen. Virology. 192:  402-414.


4.                    Friedman, P.F., Chen, X., Bargonetti, J., and C. Prives.  Immunopurified p53 protein is an unusually shaped tetramer that binds directly to DNA. 1993. Proc. Natl. Acad. Sci. U.S.A. 90:  3319-3323.


72.       Prives, C., (1993) Doing the right thing: Feedback control and p53. Current Opinion  in Cell Biology. 5:  214-218.


5.                    Prives, C., and Manfredi, J.J. (1993) p53 in Tiberias: Review of Sixth International p53  Meeting. Genes & Dev.7:  525-534.


74.       Manfredi, J.J. and Prives, C. (1993)  Primary rat cells expressing a hybrid polyomavirus-simian virus 40 (SV40) large T antigen have altered growth properties.  J. Virol. 67:  4750-4759.


6.                    Wang, E. Bhattachayra, S. and C. Prives.  (1993) The replication function of polyoma large T antigen is regulated by  phosphorylation. J. Virol. 67:  6788-6796.


76.       Chen, X., H. Zhu., G. Farmer, R. Prywes and C. Prives. (1993) p53 and TATA binding  protein cooperate to bind to DNA. Genes & Dev. 7:  1837-1849.


7.                    Reynisdottir,I., H. E. Lorimer,  P.N. Friedman, E. H. Wang and C. Prives (1993). Phosphorylation and active ATP hydrolysis are not required for SV40 T antigen hexamer formation. J. Biol. Chem. 268:  24647-24654.


78.       Bargonetti, J., J. Manfredi, X. Chen, D. Marshak and C. Prives. (1993). A proteolytic fragment of wild-type but not mutant p53 spanning the central conserved portion of the protein contains the sequence specific DNA binding domain.  Genes & Dev.7:  2565-2574.


8.                    Moses, K. and Prives, C. (1994) A unique subpopulation of DNA polymerase interacts with polyoma T antigen and stimulates DNA replication. Mol. Cell. Biol.14:  2767-2776.


80.       Manfredi, J.J. and Prives, C.  Review: Simian virus 40 large T antigen contains multiple transforming regions. Biochim Biophys Acta 1198:  65-83 (1994).


9.                    Prives, C. 1994  How Loops, β sheets and α Helices help us to understand p53. Cell. 78:  1-4.


10.                 Prives, C., Bargonetti, J., Farmer, G., Ferrari, E., Friedlander, P., Jayaraman, L., Pavletich, N, and U. Hubscher. 1994. The DNA binding properties of the p53 tumor suppressor protein. Cold Spring Harbor Symposium on Quantitative Biology: Molecular Genetics of Cancer. Vol 59:  207-213.


83.       Wang, Y., Farmer, G., Soussi, T., and C. Prives. Xenopus laevis p53 protein: sequence specific DNA binding, transcriptional regulation and oligomerization are conserved in evolution. (1995) Oncogene 10:  779-784 .


11.                 Truant, R., Antunovic, J., Greenblatt, J., Prives, C., and Cromlish, J. A. Direct interaction of the Hepatitus B Virus HBx protein with p53 leads to inhibition by HBx of p53 response element-directed transactivation. (1995) J. Virol. 69:  1851-1859.


85.       Bruckner, A., Stadlbauer, F., Guarino, L.A., Brunahl., Schneider, C. Rehfuess, C., Prives, C., Fanning, E., and Nasheuer, H-P. The mouse DNA polymerase α-primase subunit p48 mediates species specific replication of polyoma virus DNA in vitro.  Mol. Cell Biol. (1995) Mol. Cell. Biol. 15:  1716-1724.


12.                 Wang, Y. and C. Prives. Increased and Altered DNA Binding of Human p53 by S and G2/M but not G1 Cyclin Dependent Kinases (1995) Nature 376:  88-91.


13.                 Jayaraman, L. and C. Prives. (1995) Activation of p53 Sequence-specific DNA Binding by Short Single Strands of DNA Requires the p53 C-terminus. Cell 81:  1021-1029


88.     Chen, X., Bargonetti, J. and C. Prives. (1995) p53, through p21 (WAF1/CIP1) Induces  Cyclin D1 Synthesis. Cancer Research 55:  4257-4263.


89.       Miller, S., Farmer, G. and C. Prives. (1995) p53 Inhibits DNA Replication In Vitro in a DNA-Binding-Dependent Manner. (1995) Mol. Cell. Biol. 15:  6554-6560.


14.                 Bhattacharyya, S., Lorimer, H.E. and C. Prives. (1995) Murine Polyomavirus and  Simian Virus 40 Large T Antigens Produce Different Structural Alterations in Viral Origin DNA. J. Virol. 69:  7579-7585.


91.       Ko, L. and C. Prives. (1996) p53: Puzzle and Paradigm. Genes & Dev.10: 1054-1072.


15.                 Friedlander, P., Y. Legros, T. Soussi, and C. Prives. (1996) Regulation of mutant p53 temperature sensitive DNA binding. J. Biol. Chem. 271: 25468-25478.


93.       Farmer, G. J. Colgan, T. Nakatani, J. Manley and C. Prives. (1996) Functional interactions between p53 and TFIID in vivo. Mol. Cell. Biol. 16:  4295-4304.


16.                 Farmer, G., Friedlander, P., Colgan, J., Manley, J.L. and C. Prives (1996) Transcriptional repression by p53 involves molecular  interactions distinct from those with the TATA-box binding protein. Nucleic Acids Research 24:  4281-4288.


17.                 Friedlander, P. Y. Haupt, Prives, C. and M. Oren. (1996) A mutant p53 that discriminates between p53 responsive genes cannot induce apoptosis. Mol Cell Biol. 16:  4961-4971.          


18.                 Chen, X., Ko, L., Jayaraman, L. and C. Prives. 1996. p53 levels, functional domains and DNA damage determine the extent of the apoptotic response of tumor cells. Genes & Dev.10:  2438-2451.


19.                 Okamoto, K., Kamibayashi, C., Serrano, M., Prives, C., Mumby, M.C. and Beach, D. 1996. p53-dependent association between cyclin G and the B' subunit of protein phosphatase 2A. Mol. Cell Biol.16:  6593-6602.


20.                 Foukal, D.H., Murthy, K.G.K., Raabe, T.,Prives, C. and Manley, J.L. 1996. Repression of poly(A) polymerase by p34cdc2/cyclin B phosphorylation. Nature.384:  282-285.


21.                 Oren, M. and C. Prives. 1996. p53: upstream, downstream and off stream. Review of the 8th p53 workshop (Dundee July 5-9 1996). BBA Reviews on Cancer. 1288:  R13-19 (1996).


22.                 Jayaraman, L., Murthy, K. G. K., Curran, T., Xanthoudakis, S., and C. Prives. 1997  Identification of redox/repair protein Ref-1 as an activator of p53. Genes & Dev.11:  558-570.


23.                 Miller, S.D., Moses, K., Jayaraman and C. Prives. (1997) Complex formation between p53 and RP-A inhibits the sequence specific DNA binding of p53 and is regulated by single stranded DNA. Mol. Cell. Biol. 17:  2194-2201.


24.                 Cain, C., Shieh, S-Y, and C. Prives. (1997) Signalling to the C-terminus of p53. in "Oncogenes as Transcriptional Regulators. Volume 2:Cell Cycle Regulators and Chromosomal Translocation" ed. M. Yaniv and J. Ghysdael. Birkhauser Verlag Publishers. p. 63-75.


103.     Jayaraman, l. Freulich, E and C. Prives. 1997. Functional dissection of the p53 tumor suppressor protein. Methods in Enzymology. 283:  245-256.


25.                 Li, H., Bhattacharyya, S., and C. Prives. 1997 Regulation of the replication functions of polyoma large T antigen by S- and G2- phase cyclin dependent kinases. J. Virol. 71:  6469-6485.


26.                 Shieh, S-Y., M. Ikeda, Y. Taya, and C. Prives. 1997. DNA damage-induced phosphorylation of p53 alleviates inhibition by mdm2. Cell 91:  325-334.


106.     Ko, L.J., X. Chen, S-Y Shieh, L. Jayaraman, K. Tamai, Y. Taya, C. Prives and Zhen-Qiang Pan. 1997. p53 is phosphorylated by CDK7/cyclin H in a p36/MAT1 dependent manner. Mol Cell Biol. 17:  7220-7229.


27.                 Bargonetti, J., Chicas, A., White, D., and C. Prives. 1997. p53 Represses Sp1 DNA p53 DNA binding and HIV-LTR directed transcription. Cell Mol Biol 1997 43:  935-49.


28.                 Niculescu, A.B. 3rd., Chen, X., Smeets, M., Hengst, L., Prives, C. and S. I. Reed. 1998.  Effects of p21 (Cip1/Waf1) at both the G1/S and the G2/M cell cycle transitions: pRB is a critical determinant in blocking DNA replication and in preventing endoreduplication. Mol. Cell Biol. 18:  629-643.


29.                 Jayaraman, L., K.G.K. Murthy, J. l. Manley, M. Bustin and C. Prives. 1998.   Identification of  HMG-1 as a unique activator of p53. Genes & Dev. 12:  462-472.


30.                 Colgan, D.F., Murthy, K.G., Zhao, W. Prives, C. and J. L. Manley. 1998. Inhibition of poly (A) polymerase requires p34cdc2/cyclin B phosphorylation of multiple consensus and non-consensus sites.  EMBO J. 17: 1053-1062.


31.                 DiComo,C.J. and C. Prives. 1998. Human tumor-derived p53 proteins exhibit binding site selectivity and temperature sensitivity for transactivation in a yeast-based assay.  Oncogene. 16:  2527-2539.


112.     de Stanchina, E., McCurrach, M.E., Zindy, F., S-Y. Sjhieh, Ferbeyre, G., Samuelson, A.V., Prives, C., Roussel, M.F., Sherr, C.J. and S. Lowe. (1998). E1a signalling to p53 involves the p19ARF tumor suppressor. Genes. Dev. 12:  2434-2443.


32.                  Banin, S., Moyal, L., Khostravi, R., Shieh, S-Y., Taya, Y., Anderson, C.W., Chessa, L.,  Smorodinsky, N.I., Prives, C., Shiloh, Y. and Ziv, Y. (1998) Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science. 281:  1674-1677. 


114.     Jayaraman L. and Prives, C. Covalent and non-covalent modifiers of the p53 protein. (1998)   Cell and Molecular Life Sciences. Ed. Moshe Oren,  55:76-87.


33.                 Prives. C. (1998) Signalling to p53: breaking the p53:Mdm2 circuit. Cell.95:  5-8.


116.     Di Como, C.J., Gaiddon, C. and C. Prives. 1999. p73 function is inhibited by tumor-derived p53 mutants in mammalian cells. Mol Cell Biol. 19: 1438-1499.


34.                 Pridhod'ko, G.G., Wang, Y., Freulich, E., Prives, C. and L. K. Miller. 1999. Baculovirus p33 binds human p53 and enhances p53-mediated apoptosis. J. Virol. 73:  1227-1234.


35.                 Tibbetts R.S., Brumbaugh, K.M., Williams, J.M., Sarkaria, J.N., Cliby, W.A., Shieh,S-Y, Taya ,Y., Prives, C.,  and Abraham, R.T. 1999. A role for ATR in the DNA damage-induced phosphorylation of p53. Genes Dev. 13:  152-157


36.                 van Lookeren Campagne, M., Okamoto, K., Prives, C., and Gill, R. 1999. Developmental expression and co-localization of cyclin G1 and the B' subunits of protein phosphatase 2a in neurons. Brain Res. Mol. Brain Res. 64:  1-10.


37.                 Vassilev, A., Yamauchi, J., Kotani, T., Prives, C., Avantaggiati, M.L., Qin, J., Nakatani, Y.,1999. The 400 kDa subunit of the PCAF histone acetylase complex belongs to the ATM superfamily. Mol Cell 2:  869-877.


121.     Prives, C., and Hall, P.A., 1999. The p53 pathway. J. Pathology.  187: 112-126


122.     Reynisdottir, I., S. Bhattacharyya and C. Prives. 1999. Human pRB protein inhibits polyoma origin DNA replication in vitro. J. Virol. 73:                                                 3004-3013.


123.     Shieh, S-Y., Taya, Y. and C. Prives. 1999. Oligomerization of p53 is  required for DNA-damage-induced phosphorylation at the N-terminus of p53. EMBO J. 18:1815-1823.


124.                                                                                                                                                                                                                                    Okamoto, K. and C. Prives A role of cyclin G in the process of apoptosis. 1999. Oncogene. 18: 4606-4615.


125.          Gaiddon, C., Moorthy, N.C.  and C. Prives. 1999. Ref-1 regulates  the transactivation and pro-apoptotic functions of p53 in vivo. EMBO J. 18: 5609-5621.


126.     White E,  and C. Prives 1999. DNA damage enables p73. Nature 399: 734-5


127.     Cordon-Cardo, C, and C. Prives. 1999. At the Crossroads of Inflammation and         

            Tumorigenesis. J. Exp. Med. 190: 1367-1370.


128.     Shieh, S-Y., Ahn, J., Tamai, K., Taya, Y., and C. Prives. 2000. The human homologues of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage inducible sites. Genes &. Dev. 14: 289-300.


129.  Ollmann, M., Young,L.M., Di Como, C.J. Karim, F., Belvin, M., Roberts, S.,  Whittaker, K.,  Demsky, M., Fisher,  W.W., Buchman, A., Duyk,G., Friedman, L., Prives, C and C. Kopczynski  2000.  Drosophila p53 is a Structural and Functional Homolog of the Tumor  Suppressor p53. Cell 101: 91-101.


130.    Ferbeyre, G., de Stanchina, E., Querido, E., Baptiste, N., Prives, C. and , S.W.Lowe 2000. PML is induced by oncogenic ras and promotes premature senescence. Genes & Dev. 14:2015-27


131.     Bond G.L., Prives, C., J. L. Manley 2000. Poly(A) polymerase phosphorylation is dependent   on novel interactions with cyclins. Mol Cell Biol 20: 5310-20.


132.     Cain, C., Miller, S., Ahn, J and C. Prives  2000. The N-Terminus of p53 Regulates Its  Dissociation From DNA. J. Biol. Chem. 275:39944-53.


132.     Gottifredi, V., Shieh, S-Y,  Taya ,Y., and C. Prives 2001 P53 Accumulates but is Functionally  Impaired when DNA Synthesis is Blocked. Proc. Natl. Acad. Sci. U.S.A.  98:1036-1041.


133.    Gottifredi, V.,  Karni-Schmidt, O., Shieh, S-Y.,  and C. Prives,  2001. P53 down-regulates hCHK1  through p21. Mol. Cell. Biol 21:1066-1076..


134.     Zhou, J.,  Ahn, J., Wilson, S., and C. Prives. 2001 A Role for p53 in Base Excision Repair. EMBO J.20 914-923.


135.     Gaiddon C, Lokshin M., Ahn J. T. Zhang and Prives C. 2001. A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain.  Mol Cell Biol. 21:1874-1887.


136.     Gottifredi., V., S-Y Shieh1 and C. Prives 2000.Regulation of p53 after different forms of stress and at different cell cycle stages. Cold Spring Harbor Symp. Vol VIV.


137.     Gottifredi, V and C. Prives. 2001. P53 and PML: New partners in tumor suppression. Trends Cell Biol.  11: 184-187.


138.     Zhang T., and C. Prives. 2001 Cyclin A-CDK phosphorylation regulates Mdm2 protein interactions. 2001 J. Biol. Chem.  276: 29702-10.


139.     Gottifredi, V., and C. Prives. 2001 Getting p53 Out of the Nucleus. 2001 Science  292:1851-2.


140.     Ahn, J., and C. Prives. 2001 The C-terminus of p53: the more you learn the less you know. Nat  Struct Biol. 8: 730-2.


141.     Baptiste, N.,  Friedlander, P., Chen X.,  and C. Prives. 2001.The pro-domain of p53 is required for cooperation with anti-neoplastic agents to promote apoptosis of tumor cells. Oncogene 21: 9-21.


142.    Prives, C. and J.L. Manley. 2001. Why is p53 acetylated? Cell, 107: 815-818    


143.     Okamoto, K., H. Li., Jensen , M., Zhang, T.,  Thorgeirsson S., and C. Prives. 2002 Cyclin G Recruits PP2A to Dephosphorylate Mdm2.  Molecular Cell. 9: 761-771.


144.    Urist, M. and C. Prives. 2002 P53 leans on its siblings. Cancer Cell.  May  311-313. 


145.    McKinney, K. and Prives, C. Efficient specific DNA binding by p53 requires both its central  and C-terminal domains as revealed by studies with HMG-1/HMGB1. 2002.

Mol Cell Biol  22: 6797-680.


146.     Ahn, J. and C. Prives. 2002 Human Chk2 forms active monomers and dimers upon DNA  damage and Thr68 phosphorylation is not required for maintenance of kinase activity. J. Biol. Chem. 277: 48418-26.


147.          Haupt, Y., Robles, A.I., Prives, C and Rotter, V. 2003 Deconstruction of p53 functions  and  regulation. Oncogene.  21:8223-31.


148.          Gaiddon, G., Lokshin, M, Gross, I., Levasseur, D., Taya Y., Loeffler, J-P., and C. Prives. 2003. Cyclin-dependent kinases phosphorylate p73 at threonine 86 in a cell cycle dependent manner and negatively regulate p73 functions. J. Biol. Chem. 278: 27421-31.


149.          Ahn, J, Urist, M, and C. Prives. 2003. Questioning the Role of Chk2 in the p53 DNA Damage Response. J. Biol. Chem. 278: 20480-9.


150.          Zhou, J. and C. Prives. 2003. Replication of damaged DNA in vitro is blocked by p53.  Nucleic Acids Research.  31: 3881-92.


151.      Puig, P., Capodieci, P., Drobnjak, M., Verbel, D., Prives, C., Cordon-Cardo, C., and DiComo, C. J. 2003. p73 expresion in Human Normal and Tumor Tissues: Loss of p73 Expression is Associated with Tumor Progression in Bladder Cancer. Clinical Cancer Research. 9:5642-51.


152.      Poyurovsky, M.,   Jacq, X., Ma, C., Karni-Schmidt, O., Parker., P.J.,  Chalfie, M., Manley, J.L., and C. Prives. 2003. Nucleotide binding by the Mdm2 RING domain  facilitates ARF-independent Mdm2 nucleolar localization. Molecular Cell. 12: 875-887.


153.      Gonzalez, S., Prives, C., Cordon-Cardo, C. 2003. P73 Regulation by                                       Chk1 in response to DNA damage. Mol Cell Biol. 22: 8161-71.


154.    Gottifredi, V., McKinney, K., Poyurovsky, M., and C. Prives. Decreased p21 levels are required for efficient restart of DNA synthesis after S phase block. 2004. J. Biol. Chem. 279: 5802-10.


155.          Baptiste N., and Prives C. p53 in the cytoplasm: a question of overkill? 2004. Cell  116: 487-9.


156.          Urist, M. and C. Prives. The lynchpin? Pin1 meets p73. 2004. Cancer Cell. 5: 515-7.  


157.          Ahn, J., Urist, M. and Prives C., 2004. DNA Repair. 3: 1039-1047.


158.          McKinney, K. M., Mattia, M., Gottifredi, V. and C. Prives.   2004. p53 Linear Diffusion Along  DNA Requires its C-terminus. Mol Cell. 16: 413-424.


159.          Urist, M.,  Tanaka, T., Poyurovsky, M.V. and C. Prives.  2004. p73 Induction after DNA Damage is Regulated by Checkpoint Kinases, Chk1 and Chk2. Genes Dev. 18: 3041-3054.


160.          Chuikov, S., Kurash, J. K., Wilson, J.,  Ivanov, G.S.,  McKinney K.,  Tempst, P.,  Prives, C., Gamblin, S., Barlev, N., and D. Reinberg. 2004.  Regulation of p53 Activity through Lysine Methylation. Nature. 432: 353-359.