Publications

2014

Julien O, Kampmann M, Bassik MC, Zorn JA, Venditto VJ, Shimbo K, Agard NJ, Shimada K, Rheingold AL, Stockwell BR, Weissman JS, Wells JA. Unraveling the mechanism of cell death induced by chemical fibrils. Nat Chem Biol. 2014 Sep 28 [pubmedpdf]

Galluzzi L, Bravo-San Pedro JM, Vitale I, Aaronson SA, Abrams JM, Adam D, Alnemri ES, Altucci L, Andrews D, Annicchiarico-Petruzzelli M, Baehrecke EH, Bazan NG, Bertrand MJ, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Bredesen DE, Brenner C, Campanella M, Candi E, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, Di Daniele N, Dixit VM, Dynlacht BD, El-Deiry WS, Fimia GM, Flavell RA, Fulda S, Garrido C, Gougeon ML, Green DR, Gronemeyer H, Hajnoczky G, Hardwick JM, Hengartner MO, Ichijo H, Joseph B, Jost PJ, Kaufmann T, Kepp O, Klionsky DJ, Knight RA, Kumar S, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lugli E, Madeo F, Malorni W, Marine JC, Martin SJ, Martinou JC, Medema JP, Meier P, Melino S, Mizushima N, Moll U, Muñoz-Pinedo C, Nuñez G, Oberst A, Panaretakis T, Penninger JM, Peter ME, Piacentini M, Pinton P, Prehn JH, Puthalakath H, Rabinovich GA, Ravichandran KS, Rizzuto R, Rodrigues CM, Rubinsztein DC, Rudel T, Shi Y, Simon HU, Stockwell BR, Szabadkai G, Tait SW, Tang HL, Tavernarakis N, Tsujimoto Y, Vanden Berghe T, Vandenabeele P, Villunger A, Wagner EF, Walczak H, White E, Wood WG, Yuan J, Zakeri Z, Zhivotovsky B, Melino G, Kroemer G. Essential versus accessory aspects of cell death: recommendations of the NCCD 2015. Cell Death Differ. 2014 Sep 19. [pubmedpdf]

Wolpaw AJ, Stockwell BR. Multidimensional profiling in the investigation of small-molecule-induced cell death. Methods Enzymol 2014 Jul; 545:265-302 [pubmedpdf]

Dixon SJ, Patel DN, Welsch M, Skouta R, Lee ED, Hayano M, Thomas AG, Gleason CE, Tatonetti N, Slusher BS, Stockwell BR. Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis. eLife 2014 May 20 [pubmedpdf]

Cantley AM, Welsch ME, Ambesi-Impiombato A, Sanchez-Martin M, Kim MY, Bauer A, Ferrando A, Stockwell BR. Small Molecule that Reverses Dexamethasone Resistance in T-cell Acute Lymphoblastic Leukemia (T-ALL). ACS Med Chem Letters 2014 Apr 25;5(7):754-9 [pubmedpdf]

Skouta R, Dixon SJ, Wang J, Dunn DE, Orman M, Shimada K, Rosenberg P, Lo D, Weinberg J, Linkermann A, Stockwell BR. Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models. J Am Chem Soc 2014 Mar 4 [pubmedpdf]

Yang WS, SriRamaratnam R, Welsch ME, Shimada K, Skouta R, Viswanathan VS, Cheah JH, Clemons PA, Shamji AF, Clish CB, Brown LM, Girotti AW, Cornish VW, Schreiber SL, Stockwell BR. Regulation of Ferroptotic Cancer Cell Death by GPX4. Cell 2014 Jan 16; 156(1):317-331 [pubmedpdf]

2013

Dixon SJ, Stockwell BR. The role of iron and reactive oxygen species in cell death. Nat Chem Biol 2013 Dec 17;10(1):9-17 [pubmedpdf]

Basu A, Bodycombe NE, Cheah NH, Price EV, Liu K, Schaefer GI, Ebright RY, Stewart ML, Ito D, Wang S, Bracha AL, Liefelds A, Wawer M, Gilbert JC, Wilson AJ, Stransky N, Kryukov GV, Dancik V, Barretina J, Garraway LA, Hon CS, Munoz B, Bittker JA, Stockwell BR, Khabele D, Stern AM, Clemons PA, Shamji AF, Schreiber SL. An Interactive Resource to Identify Cancer Genetic and Lineage Dependencies Targeted by Small Molecules. Cell 2013 Aug 29;154(5):1151-1161 [pubmedpdf]

Varma H, Gangadhar NM, Letso RR, Wolpaw AJ, Sriramaratnam R, Stockwell BR. Identification of a small molecule that induces ATG5-and-cathepsin-l-dependent cell death and modulates polyglutamine toxicity. Exp Cell Res 2013 Apr 12. [pubmedpdf]

Letso RR, Bauer AJ, Lunn MR, Yang WS, Stockwell BR. Small Molecule Screen Reveals Regulation of Survival Motor Neuron Protein Abundance by Ras Proteins. ACS Chem Biol 2013 Mar 15. [pubmedpdf]

2012

Kosuri P, Alegre-Cebollada J, Feng J, Kaplan A, Inglés-Prieto A, Badilla CL, Stockwell BR, Sanchez-Ruiz JM, Holmgren A, Fernández JM. Protein folding drives disulfide formation. Cell 2012 Nov 9;151(4):794-806 [pubmedpdf]

Kaplan A, Stockwell BR. Therapeutic approaches to preventing cell death in Huntington disease. Prog Neurobiol 2012 Dec;99(3):262-80 [pubmedpdf]

Skouta R, Hayano M, Shimada K and Stockwel BR. Design and synthesis of Pictet-Spengler condensation products that exhibit oncogenic-RAS synthetic lethality and induce non-apoptotic cell death. Bioorg Med Chem Lett 2012 Sep 1;22(17):5707-13 [pubmedpdf]

Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R,Zaitsev EM, Gleason CE, Patel DN, Bauer AJ, Cantley AM, Yang WS, Morrison B, Stockwell BR. Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death. Cell 2012 May;149(5), 1060-1072 [pubmedpdf]

Weiwer M, Bittker JA, Lewis TA, Shimada K, Yang WS, Macpherson L, Dandapani S, Palmer M, Stockwell BR, Schreiber SL, Munoz B. Development of small-molecule probes that selectively kill cells induced to express mutant RAS. Bioorg Med Chem Lett 2012 Feb;22(4):1822-6. [pubmedpdf]

Yang W, Shimada K, Delva D, Patel M, Ode E, Skouta R, Stockwell BR. Identification of simple compounds with microtubule-binding activity that inhibit cancer cell growth with high potency. ACS Med Chem Letters 2012 Jan;3(1):35-38. [pubmedpdf]

2011

Wolpaw AJ, Shimada K, Skouta R, Welsch ME, Akavia UD, Pe'er D, Shaik F, Bulinski JC, Stockwell BR. Modulatory Profiling Identifies Mechanisms of Small Molecule-Induced Cell Death. Proc Natl Acad Sci USA 2011 Sep;108(39):E771-80. [pubmedpdf]

Herman AG, Hayano M, Poyurovsky MV, Shimada K, Skouta R, Prives C, Stockwell BR. Discovery of Mdm2-MdmX E3 Ligase Inhibitors Using a Cell-Based Ubiquitination Assay. Cancer Discovery 2011 Sep;1(4):312-25. [pubmedpdf]

Bauer AJ, Gieschler S, Lemberg KM, McDermott AE, Stockwell BR. Functional Model of Metabolite Gating by Human Voltage-Dependent Anion Channel 2. Biochemistry 2011 May;50(17):3408-10. [pubmedpdf]

2010

Hoffstrom BG, Kaplan A, Letso R, Schmid RS, Turmel GJ, Lo DC, Stockwell BR. Inhibitors of protein disulfide isomerase suppress apoptosis induced by misfolded proteins. Nat Chem Biol 2010 Dec;6(12):900-6. [pubmedpdf]

Varma H, Yamamoto A, Sarantos MR, Hughes RE, Stockwell BR. Mutant Huntingtin Alters Cell Fate in Response to Microtubule Depolymerization via GEF-H1-RhoA-ERK Pathway. J Biol Chem 2010 Nov;285(48):37445-57. [pubmedpdf]

Cancer Target Discovery and Development Network, Schreiber SL, Shamji AF, Clemons PA, Hon C, Koehler AN, Munoz B, Palmer M, Stern AM, Wagner BK, Powers S, Lowe SW, Guo X, Krasnitz A, Sawey ET, Sordella R, Stein L, Trotman LC, Califano A, Dalla-Favera R, Ferrando A, Iavarone A, Pasqualucci L, Silva J, Stockwell BR, Hahn WC, Chin L, DePinho RA, Boehm JS, Gopal S, Huang A, Root DE, Weir BA, Gerhard DS, Zenklusen JC, Roth MG, White MA, Minna JD, MacMillan JB, Posner BA. Towards patient-based cancer therapeutics. Nat Biotech 2010 Sep;28(9):904-6. [pubmedpdf]

Welsch ME, Snyder SA, Stockwell BR. Privileged scaffolds for library design and drug discovery. Curr Opin Chem Biol 2010 Jun;14(3):347-361. [pubmedpdf]

Dixon SJ, Stockwell BR. Drug discovery: Engineering drug combinations. Nat Chem Biol 2010 May;6(5):318-319. [pubmedpdf]

2009

Dixon SJ, Stockwell BR. Identifying druggable disease-modifying gene products. Curr Opin Chem Biol 2009 Dec;13(5-6):549-555. [pubmedpdf]

2008

Lehar J, Stockwell BR, Giaever G, Nislow C. Combination chemical genetics. Nat Chem Biol 2008 Nov;4(11):674-681. [pubmedpdf]

Gangadhar NM, Firestein SJ, Stockwell BR. A novel role for jun N-terminal Kinase signaling in olfactory sensory neuronal death. Mol Cell Neurosci 2008 Aug;38(4):518-525. [pubmedpdf]

Yang WS, Stockwell BR. Inhibition of casein kinase 1-epsilon induces cancer-cell-selective, PERIOD2-dependent growth arrest. Genome Biology 2008 Jun;9(6):R92. Epub 2008 Jun. [pubmedpdf]

Bauer AJ, Stockwell BR. Neurobiological Applications of Small Molecule Screening Chemical Reviews 2008 Mar;108(5):1774-1786. [pubmedpdf]

Yang WS, Stockwell BR. Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells. Chemistry & Biology 2008 Mar;15(3):234-245. [pubmedpdf]

Varma H, Lo DC, Stockwell BR. High throughput screening for neurodegeneration and complex disease phenotypes. Comb Chem High Throughput Screen 2008 Mar;11(3):238-248. [pubmedpdf]

Antipova AA, Stockwell BR, Golub TR. Gene expression-based screening for inhibitors of PDGFR signaling. Genome Biology 2008;9(3):R47. [pubmedpdf]

2007

Yagoda N, von Rechenberg M, Zaganjor E, Bauer AJ, Yang WS, Fridman DJ, Wolpaw AJ, Smukste I, Peltier JM, Boniface JJ, Smith R, Lessnick SL, Sahasrabudhe S, Stockwell BR. RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels. Nature 2007 Jun;447(7146):865-869. [pubmedpdf]

Varma H, Voisine C, DeMarco CT, Cattaneo E, Lo DC, Hart AC, Stockwell BR. Selective inhibitors of death in mutant huntingtin cells. Nat Chem Biol 2007 Feb;3(2):99-100. [pubmedpdf]

Gangadhar NM, Stockwell BR. Chemical genetic approaches to probing cell death. Curr Opin Chem Biol 2007 Feb;11(1):83-87. [pubmedpdf]

Lehar J, Zimmermann GR, Krueger AS, Molnar RA, Ledell JT, Heilbut AM, Short GF, Giusti LC, Nolan GP, Magid OA, Lee MS, Borisy AA, Stockwell BR, Keith CT. Chemical combination effects predict connectivity in biological systems. Mol Syst Biol 2007;3. [pubmedpdf]

Voisine C, Varma H, Walker N, Bates EA, Stockwell BR, Hart AC. Identification of Potential Therapeutic Drugs for Huntington's Disease using Caenorhabditis elegans. PLoS ONE 2007;2(6):e504. [pubmedpdf]

Varma H, Cheng R, Voisine C, Hart AC, Stockwell BR. Inhibitors of metabolism rescue cell death in Huntington's disease models. Proc Natl Acad Sci USA 2007;104(36):14525 -14530. [pubmedpdf]

2006

Letso RR, Stockwell BR. Chemical biology: renewing embryonic stem cells. Nature 2006 Dec;444(7120):692-693. [pubmedpdf]

Desai UA, Pallos J, Ma AAK, Stockwell BR, Thompson LM, Marsh JL, Diamond MI. Biologically active molecules that reduce polyglutamine aggregation and toxicity. Hum Mol Genet 2006 Jul;15(13):2114 -2124. [pubmedpdf]

Yen L, Magnier M, Weissleder R, Stockwell BR, Mulligan RC. Identification of inhibitors of ribozyme self-cleavage in mammalian cells via high-throughput screening of chemical libraries. RNA 2006 May;12(5):797-806. [pubmedpdf]

Stockwell BR. Preventing protein secretion with chemical glue. Nat Chem Biol 2006 Jan;2(1):7-8. [pubmedpdf]

Herman AG, Stockwell BR. Enzyme Annotation with Chemical Tools. Chemistry & Biology 2006;13(10):1013-1014. [pubmedpdf]

Moffat J, Grueneberg DA, Yang X, Kim SY, Kloepfer AM, Hinkle G, Piqani B, Eisenhaure TM, Luo B, Grenier JK. A Lentiviral RNAi Library for Human and Mouse Genes Applied to an Arrayed Viral High-Content Screen. Cell 2006;124(6):1283-1298. [pubmedpdf]

Smukste I, Bhalala O, Persico M, Stockwell BR. Using small molecules to overcome drug resistance induced by a viral oncogene. Cancer Cell 2006;9(2):133-146. [pubmedpdf]

2005

Keith CT, Borisy AA, Stockwell BR. Multicomponent therapeutics for networked systems. Nat Rev Drug Discov 2005 Jan;4(1):71-78. [pubmedpdf]

Lunn M, Stockwell B. Chemical Genetics and Orphan Genetic Diseases. Chemistry & Biology 2005;12(10):1063-1073. [pubmedpdf]

Smukste I, Stockwell BR. Advances in Chemical Genetics. Annu Rev Genomics Hum Genet 2005;6(1):261-286. [pubmedpdf]

2004

Stockwell BR. Exploring biology with small organic molecules. Nature 2004 Dec;432(7019):846-854. [pubmedpdf]

Bailey SN, Sabatini DM, Stockwell BR. Microarrays of small molecules embedded in biodegradable polymers for use in mammalian cell-based screens. Proc Natl Acad Sci USA 2004 Nov;101(46):16144 -16149. [pubmedpdf]

Lunn MR, Root DE, Martino AM, Flaherty SP, Kelley BP, Coovert DD, Burghes AH, thi Man N, Morris GE, Zhou J, Androphy EJ, Sumner CJ, Stockwell BR. Indoprofen Upregulates the Survival Motor Neuron Protein through a Cyclooxygenase-Independent Mechanism. Chemistry & Biology 2004 Nov;11(11):1489-1493. [pubmedpdf]

Stegmaier K, Ross KN, Colavito SA, O'Malley S, Stockwell BR, Golub TR. Gene expression-based high-throughput screening(GE-HTS) and application to leukemia differentiation. Nat Genet 2004 Mar;36(3):257-263. [pubmedpdf]

Stockwell BR. The biological magic behind the bullets. Nat Biotech 2004 Jan;22(1):37-38. [pubmedpdf]

Kelley BP, Lunn MR, Root DE, Flaherty SP, Martino AM, Stockwell BR. A Flexible Data Analysis Tool for Chemical Genetic Screens. Chemistry & Biology 2004;11(11):1495-1503. [pubmedpdf]

Kelley BP, Yuan B, Lewitter F, Sharan R, Stockwell BR, Ideker T. PathBLAST: a tool for alignment of protein interaction networks. Nucleic Acids Res 2004;32(Web Server):W83-W88. [pubmedpdf]

2003

Kelley BP, Sharan R, Karp RM, Sittler T, Root DE, Stockwell BR, Ideker T. Conserved pathways within bacteria and yeast as revealed by global protein network alignment. Proc Natl Acad Sci USA 2003 Sep;100(20):11394-11399. [pubmedpdf]

Borisy AA, Elliott PJ, Hurst NW, Lee MS, Leh͍r J, Price ER, Serbedzija G, Zimmermann GR, Foley MA, Stockwell BR, Keith CT. Systematic discovery of multicomponent therapeutics. Proc Natl Acad Sci USA 2003 Jun;100(13):7977 -7982. [pubmedpdf]

Dolma S, Lessnick SL, Hahn WC, Stockwell BR. Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells. Cancer Cell 2003 Mar;3(3):285-296. [pubmedpdf]

Smukste I, Stockwell BR. Restoring functions of tumor suppressors with small molecules. Cancer Cell 2003;4(6):419-420. [pubmedpdf]

Root DE, Flaherty SP, Kelley BP, Stockwell BR. Biological Mechanism Profiling Using an Annotated Compound Library. Chemistry & Biology 2003;10(9):881-892. [pubmedpdf]

Root DE, Kelley BP, Stockwell BR. Detecting Spatial Patterns in Biological Array Experiments. J Biomol Screen 2003;8(4):393 -398. [pubmedpdf]

2002

Blanchard BJ, Stockwell BR, Ingram VM. Eliminating membrane depolarization caused by the Alzheimer peptide A[beta](1-42, aggr.). Biochem Biophys Res Commun 2002 May;293(4):1204-1208. [pubmedpdf]

DE Root, BP Kelley, BR Stockwell. Global analysis of large-scale chemical and biological experiments. Curr Opin Drug Discov Devel 2002 May;5(3):355-60. [pubmedpdf]

Stockwell BR. Chemical Genetic Screening Approaches to Neurobiology. Neuron 2002;36(4):559-562. [pubmedpdf]

2000

Stockwell BR. Frontiers in chemical genetics. Trends Biotechnol 2000 Nov;18(11):449-455. [pubmedpdf]

Stockwell BR. Chemical genetics: ligand-based discovery of gene function. Nat Rev Genet 2000 Nov;1(2):116-125. [pubmedpdf]

1999

Stockwell BR, Hardwick JS, Tong JK, Schreiber SL. Chemical Genetic and Genomic Approaches Reveal a Role for Copper in Specific Gene Activation. J Am Chem Soc 1999 Nov;121(45):10662-10663. [pdf]

Tan DS, Foley MA, Stockwell BR, Shair MD, Schreiber SL. Synthesis and Preliminary Evaluation of a Library of Polycyclic Small Molecules for Use in Chemical Genetic Assays. J Am Chem Soc 1999 Oct;121(39):9073-9087. [pdf]

Stockwell B, Haggarty S, Schreiber S. High-throughput screening of small molecules in miniaturized mammalian cell-based assays involving post-translational modifications. Chemistry & Biology 1999;6(2):71-83. [pubmedpdf]

1998

Muzio M, Stockwell BR, Stennicke HR, Salvesen GS, Dixit VM. An Induced Proximity Model for Caspase-8 Activation. J Biol Chem 1998 Jan;273(5):2926 -2930. [pubmedpdf]

Stockwell B. TGF-beta-signaling with small molecule FKBP12 antagonists that bind myristoylated FKBP12-TGF-beta type I receptor fusion proteins. Chemistry & Biology 1998;5(7):385-395. [pubmedpdf]

Stockwell BR, Schreiber SL. Probing the role of homomeric and heteromeric receptor interactions in TGF-beta signaling using small molecule dimerizers. Current Biology 1998;8(13):761-773. [pubmedpdf]

1997

Morgan B, Stockwell BR, Dodds DR, Andrews DR, Sudhakar AR, Nielsen CM, Mergelsberg I, Zumbach A. Chemoenzymatic approaches to SCH 56592, a new azole antifungal. J Amer Oil Chem Soc 1997;74(11):1361-1370.