Publications
2013
Varma H, Gangadhar NM, Letso RR, Wolpaw AJ, Sriramaratnam R, Stockwell BR. Identification of a small molecule that induces ATG5-and-cathepsin-l-dependent cell death and modulates polyglutamine toxicity.
Letso RR, Bauer AJ, Lunn MR, Yang WS, Stockwell BR. Small Molecule Screen Reveals Regulation of Survival Motor Neuron Protein Abundance by Ras Proteins.
2012
Kosuri P, Alegre-Cebollada J, Feng J, Kaplan A, Inglés-Prieto A, Badilla CL, Stockwell BR, Sanchez-Ruiz JM, Holmgren A, Fernández JM. Protein folding drives disulfide formation.
Kaplan A, Stockwell BR. Therapeutic approaches to preventing cell death in Huntington disease.
Skouta R, Hayano M, Shimada K and Stockwel BR. Design and synthesis of Pictet-Spengler condensation products that exhibit oncogenic-RAS synthetic lethality and induce non-apoptotic cell death.
Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R,Zaitsev EM, Gleason CE, Patel DN, Bauer AJ, Cantley AM, Yang WS, Morrison B, Stockwell BR. Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death.
Weiwer M, Bittker JA, Lewis TA, Shimada K, Yang WS, Macpherson L, Dandapani S, Palmer M, Stockwell BR, Schreiber SL, Munoz B. Development of small-molecule probes that selectively kill cells induced to express mutant RAS.
Yang W, Shimada K, Delva D, Patel M, Ode E, Skouta R, Stockwell BR. Identification of simple compounds with microtubule-binding activity that inhibit cancer cell growth with high potency.
2011
Wolpaw AJ, Shimada K, Skouta R, Welsch ME, Akavia UD, Pe'er D, Shaik F, Bulinski JC, Stockwell BR. Modulatory Profiling Identifies Mechanisms of Small Molecule-Induced Cell Death.
Herman AG, Hayano M, Poyurovsky MV, Shimada K, Skouta R, Prives C, Stockwell BR. Discovery of Mdm2-MdmX E3 Ligase Inhibitors Using a Cell-Based Ubiquitination Assay.
Bauer AJ, Gieschler S, Lemberg KM, McDermott AE, Stockwell BR. Functional Model of Metabolite Gating by Human Voltage-Dependent Anion Channel 2.
2010
Hoffstrom BG, Kaplan A, Letso R, Schmid RS, Turmel GJ, Lo DC, Stockwell BR. Inhibitors of protein disulfide isomerase suppress apoptosis induced by misfolded proteins.
Varma H, Yamamoto A, Sarantos MR, Hughes RE, Stockwell BR. Mutant Huntingtin Alters Cell Fate in Response to Microtubule Depolymerization via GEF-H1-RhoA-ERK Pathway.
Cancer Target Discovery and Development Network, Schreiber SL, Shamji AF, Clemons PA, Hon C, Koehler AN, Munoz B, Palmer M, Stern AM, Wagner BK, Powers S, Lowe SW, Guo X, Krasnitz A, Sawey ET, Sordella R, Stein L, Trotman LC, Califano A, Dalla-Favera R, Ferrando A, Iavarone A, Pasqualucci L, Silva J, Stockwell BR, Hahn WC, Chin L, DePinho RA, Boehm JS, Gopal S, Huang A, Root DE, Weir BA, Gerhard DS, Zenklusen JC, Roth MG, White MA, Minna JD, MacMillan JB, Posner BA. Towards patient-based cancer therapeutics.
Welsch ME, Snyder SA, Stockwell BR. Privileged scaffolds for library design and drug discovery.
Dixon SJ, Stockwell BR. Drug discovery: Engineering drug combinations.
2009
Dixon SJ, Stockwell BR. Identifying druggable disease-modifying gene products.
2008
Lehar J, Stockwell BR, Giaever G, Nislow C. Combination chemical genetics.
Gangadhar NM, Firestein SJ, Stockwell BR. A novel role for jun N-terminal Kinase signaling in olfactory sensory neuronal death.
Yang WS, Stockwell BR. Inhibition of casein kinase 1-epsilon induces cancer-cell-selective, PERIOD2-dependent growth arrest.
Bauer AJ, Stockwell BR. Neurobiological Applications of Small Molecule Screening
Yang WS, Stockwell BR. Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells.
Varma H, Lo DC, Stockwell BR. High throughput screening for neurodegeneration and complex disease phenotypes.
Antipova AA, Stockwell BR, Golub TR. Gene expression-based screening for inhibitors of PDGFR signaling.
2007
Yagoda N, von Rechenberg M, Zaganjor E, Bauer AJ, Yang WS, Fridman DJ, Wolpaw AJ, Smukste I, Peltier JM, Boniface JJ, Smith R, Lessnick SL, Sahasrabudhe S, Stockwell BR. RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels.
Varma H, Voisine C, DeMarco CT, Cattaneo E, Lo DC, Hart AC, Stockwell BR. Selective inhibitors of death in mutant huntingtin cells.
Gangadhar NM, Stockwell BR. Chemical genetic approaches to probing cell death.
Lehar J, Zimmermann GR, Krueger AS, Molnar RA, Ledell JT, Heilbut AM, Short GF, Giusti LC, Nolan GP, Magid OA, Lee MS, Borisy AA, Stockwell BR, Keith CT. Chemical combination effects predict connectivity in biological systems.
Voisine C, Varma H, Walker N, Bates EA, Stockwell BR, Hart AC. Identification of Potential Therapeutic Drugs for Huntington's Disease using Caenorhabditis elegans.
Varma H, Cheng R, Voisine C, Hart AC, Stockwell BR. Inhibitors of metabolism rescue cell death in Huntington's disease models.
2006
Letso RR, Stockwell BR. Chemical biology: renewing embryonic stem cells.
Desai UA, Pallos J, Ma AAK, Stockwell BR, Thompson LM, Marsh JL, Diamond MI. Biologically active molecules that reduce polyglutamine aggregation and toxicity.
Yen L, Magnier M, Weissleder R, Stockwell BR, Mulligan RC. Identification of inhibitors of ribozyme self-cleavage in mammalian cells via high-throughput screening of chemical libraries.
Stockwell BR. Preventing protein secretion with chemical glue.
Herman AG, Stockwell BR. Enzyme Annotation with Chemical Tools.
Moffat J, Grueneberg DA, Yang X, Kim SY, Kloepfer AM, Hinkle G, Piqani B, Eisenhaure TM, Luo B, Grenier JK. A Lentiviral RNAi Library for Human and Mouse Genes Applied to an Arrayed Viral High-Content Screen.
Smukste I, Bhalala O, Persico M, Stockwell BR. Using small molecules to overcome drug resistance induced by a viral oncogene.
2005
Keith CT, Borisy AA, Stockwell BR. Multicomponent therapeutics for networked systems.
Lunn M, Stockwell B. Chemical Genetics and Orphan Genetic Diseases.
Smukste I, Stockwell BR. Advances in Chemical Genetics.
2004
Stockwell BR. Exploring biology with small organic molecules.
Bailey SN, Sabatini DM, Stockwell BR. Microarrays of small molecules embedded in biodegradable polymers for use in mammalian cell-based screens.
Lunn MR, Root DE, Martino AM, Flaherty SP, Kelley BP, Coovert DD, Burghes AH, thi Man N, Morris GE, Zhou J, Androphy EJ, Sumner CJ, Stockwell BR. Indoprofen Upregulates the Survival Motor Neuron Protein through a Cyclooxygenase-Independent Mechanism.
Stegmaier K, Ross KN, Colavito SA, O'Malley S, Stockwell BR, Golub TR. Gene expression-based high-throughput screening(GE-HTS) and application to leukemia differentiation.
Stockwell BR. The biological magic behind the bullets.
Kelley BP, Lunn MR, Root DE, Flaherty SP, Martino AM, Stockwell BR. A Flexible Data Analysis Tool for Chemical Genetic Screens.
Kelley BP, Yuan B, Lewitter F, Sharan R, Stockwell BR, Ideker T. PathBLAST: a tool for alignment of protein interaction networks.
2003
Kelley BP, Sharan R, Karp RM, Sittler T, Root DE, Stockwell BR, Ideker T. Conserved pathways within bacteria and yeast as revealed by global protein network alignment.
Borisy AA, Elliott PJ, Hurst NW, Lee MS, LehÌÁr J, Price ER, Serbedzija G, Zimmermann GR, Foley MA, Stockwell BR, Keith CT. Systematic discovery of multicomponent therapeutics.
Dolma S, Lessnick SL, Hahn WC, Stockwell BR. Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells.
Smukste I, Stockwell BR. Restoring functions of tumor suppressors with small molecules.
Root DE, Flaherty SP, Kelley BP, Stockwell BR. Biological Mechanism Profiling Using an Annotated Compound Library.
Root DE, Kelley BP, Stockwell BR. Detecting Spatial Patterns in Biological Array Experiments.
2002
Blanchard BJ, Stockwell BR, Ingram VM. Eliminating membrane depolarization caused by the Alzheimer peptide A[beta](1-42, aggr.).
DE Root, BP Kelley, BR Stockwell. Global analysis of large-scale chemical and biological experiments.
Stockwell BR. Chemical Genetic Screening Approaches to Neurobiology.
2000
Stockwell BR. Frontiers in chemical genetics.
Stockwell BR. Chemical genetics: ligand-based discovery of gene function.
1999
Stockwell BR, Hardwick JS, Tong JK, Schreiber SL. Chemical Genetic and Genomic Approaches Reveal a Role for Copper in Specific Gene Activation.
Tan DS, Foley MA, Stockwell BR, Shair MD, Schreiber SL. Synthesis and Preliminary Evaluation of a Library of Polycyclic Small Molecules for Use in Chemical Genetic Assays.
Stockwell B, Haggarty S, Schreiber S. High-throughput screening of small molecules in miniaturized mammalian cell-based assays involving post-translational modifications.
1998
Muzio M, Stockwell BR, Stennicke HR, Salvesen GS, Dixit VM. An Induced Proximity Model for Caspase-8 Activation.
Stockwell B. TGF-beta-signaling with small molecule FKBP12 antagonists that bind myristoylated FKBP12-TGF-beta type I receptor fusion proteins.
Stockwell BR, Schreiber SL. Probing the role of homomeric and heteromeric receptor interactions in TGF-beta signaling using small molecule dimerizers.
1997
Morgan B, Stockwell BR, Dodds DR, Andrews DR, Sudhakar AR, Nielsen CM, Mergelsberg I, Zumbach A. Chemoenzymatic approaches to SCH 56592, a new azole antifungal.