Yang WS, Stockwell BR.
Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells.
Chem Biol. 2008 3:234-45. [pubmed pdf]Varma H, Lo DC, Stockwell BR.
High throughput screening for neurodegeneration and complex disease phenotypes.
Comb Chem High Throughput Screen. 2008 3:238-48. [pubmed pdf]Antipova AA, Stockwell BR, Golub TR.
Gene expression-based screening for inhibitors of PDGFR signaling.
Genome Biol. 2008 9:R47 [pubmed pdf]Varma H, Cheng R, Voisine C, Hart AC, Stockwell BR.
Inhibitors of metabolism rescue cell death in Huntington's disease models.
PNAS. 2007 104:14525-30. [pubmed pdf]Yagoda N, von Rechenberg M, Zaganjor E, Bauer AJ, Yang WS, Fridman DJ, Wolpaw AJ, Smukste I, Peltier JM, Boniface JJ, Smith R, Lessnick SL, Sahasrabudhe S, Stockwell BR.
RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels.
Nature. 2007 447:864-8 [pubmed pdf]Voisine C, Varma H, Walker N, Bates EA, Stockwell BR, Hart AC.
Identification of potential therapeutic drugs for huntington's disease using Caenorhabditis elegans.
PLOS One. 2007 2:e504. [pubmed pdf]Lehar J, Zimmermann GR, Krueger AS, Molnar RA, Ledell JT, Heilbut AM, Short GF 3rd, Giusti LC, Nolan GP, Magid OA, Lee MS, Borisy AA, Stockwell BR, Keith CT.
Chemical combination effects predict connectivity in biological systems.
Molecular Systems Biology. 2007 3:80. [pubmed pdf]Varma H, Voisine C, DeMarco CT, Cattaneo E, Lo DC, Hart AC, Stockwell BR.
Selective inhibitors of death in mutant huntingtin cells.
Nature Chemical Biology. 2007 3:99-100. [pubmed pdf]Gangadhar NM, Stockwell BR.
Chemical genetic approaches to probing cell death.
Current Opinion in Chemical Biology. 2007 11:83-7. [pubmed pdf]Letso RR, Stockwell BR.
Chemical biology: renewing embryonic stem cells.
Nature. 2006 444:692-3. [pubmed pdf]Herman AG, Stockwell BR.
Enzyme annotation with chemical tools.
Chemistry and Biology. 2006 10:1013-4. [pubmed pdf]Desai UA, Pallos J, Ma AA, Stockwell BR, Thompson LM, Marsh JL, Diamond MI.(2006)
Biologically active molecules that reduce polyglutamine aggregation and toxicity.
Human Molecular Genetics 15:2114-24 [pubmed pdf]Moffat J, Grueneberg DA, Yang X, Kim SY, Kloepfer AM, Hinkle G, Piqani B, Eisenhaure TM, Luo B, Grenier JK, Carpenter AE, Foo SY, Stewart SA, Stockwell BR, Hacohen N, Hahn WC, Lander ES, Sabatini DM, Root DE. (2006)A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen.
Cell,124:1283-98. [pubmed pdf]Yen L, Magnier M, Weissleder R, Stockwell BR, Mulligan RC. (2006) Identification of inhibitors of ribozyme self-cleavage in mammalian cells via high-throughput screening of chemical libraries.
RNA,12:797-806. [pubmed pdf]Smukste I, Bhalala O, Persico M, Stockwell BR.(2006) Using small molecules to overcome drug resistance induced by a viral oncogene.
Cancer Cell, 9:133-46. [pubmed pdf]Stockwell BR. (2006) Preventing protein secretion with chemical glue. Nature Chemical Biology, 1:7-8 [pubmed pdf]
Lunn MR, Stockwell BR. (2005) Chemical genetics and orphan genetic diseases. Chemistry and Biology, 12:1063-1073 [pubmed pdf]
Smukste I, Stockwell BR. (2005) Advances in chemical genetics. Annual Review of Genomics and Human Genetics, 6:261-286 [pubmed pdf]
Keith CT, Borisy AA, Stockwell BR. (2005) Multicomponent therapeutics for networked systems. Nature Reviews Drug Discovery, 4:71-78. [pubmed pdf]
Stockwell BR. (2004) Exploring biology with small organic molecules. Nature, 432(7019):846-54. [pubmed pdf]
Kelley BP, Lunn MR, Root DE, Flaherty SP, Martino AM, Stockwell BR. (2004) A flexible data analysis tool for chemical genetic screens. Chemistry & Biology, 11(11):1495-503. [pubmed pdf]
Lunn MR, Root DE, Martino AM, Flaherty SP, Kelley BP, Coovert DD, Burghes AH, Man NT, Morris GE, Zhou J, Androphy EJ, Sumner CJ, Stockwell BR. (2004) Indoprofen upregulates the survival motor neuron protein through a cyclooxygenase-independent mechanism. Chemistry & Biology, 11(11):1489-93. [pubmed pdf]
Bailey SN, Sabatini DM, and Stockwell BR. (2004) Microarrays of small molecules embedded in biodegradable polymers for use in mammalian cell-based screens. Proceedings of the National Academy of Sciences, 101(46):16144-9. [pubmed pdf]
Kelley BP, Yuan B, Lewitter F, Sharan R, Stockwell BR, and Ideker T. (2004) PathBLAST: a tool for alignment of protein interaction networks. Nucleic Acids Research, 32:W83-8. [pubmed pdf]
Stegmaier K, Ross KN, Colavito SA, O'Malley S, Stockwell BR and Golub TR. (2004) Gene expression-based high-throughput screening (GE-HTS) and application to leukemia differentiation. Nature Genetics, 36(3):257-63.
[pubmed pdf corrigendum (pdf)]Stockwell BR. (2004) The biological magic behind the bullets. Nature Biotechnology, 22(1):37-8. [pubmed pdf]
Smukste I and Stockwell BR. (2003) Restoring function of tumor suppressors with small molecules. Cancer Cell, 4(6):419-20. [pubmed pdf]
Root DE, Kelley BP, and Stockwell BR. (2003) Detecting spatial patterns in biological array experiments. Journal of Biomolecular Screening, 8(4):393-98. [pubmed pdf]
Root DE, Flaherty SP, Kelley BP, and Stockwell BR. (2003) Biological
mechanism profiling using an annotated compound library. Chemistry &
Biology, 10(9):881-92. [pubmed pdf]Kelley BP, Sharan R, Karp R, Sittler ET, Root DE, Stockwell BR and Ideker T. (2003) Conserved pathways within bacteria and yeast as revealed by global
protein network alignment. Proceedings of the National Academy of Sciences
of the USA, 100(20):11394-9. [pubmed pdf]
Borisy AA, Elliott PJ, Hurst NW, Lee MS, Lehar J, Price ER, Serbedzija G, Zimmermann GR, Foley MA, Stockwell BR, and Keith CT. (2003) Systematic discovery of multicomponent therapeutics. Proceedings of the National Academy of Sciences, 100(13):7977-82. [pubmed pdf]
Dolma S, Lessnick SL, Hahn WC, and Stockwell BR. (2003) Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells. Cancer Cell, 3(3):285-96. [pubmed pdf]
Stockwell BR. Chemical genetic screening approaches to neurobiology. Neuron, 36(4):559-62. [pubmed pdf]
Root DE, Kelley BP, and Stockwell BR. (2002) Global analysis of large-scale chemical and biological experiments. Current Opinion in Drug Discovery and Development, 5(3):355-60. [pubmed pdf]
Blanchard BJ, Stockwell BR, and Ingram VM. (2002) Eliminating membrane depolarization caused by the Alzheimer peptide (Aß1-42). Biochemical and Biophysical Research Communications, 293(4):1204-8. [pubmed pdf]
Stockwell BR. (2000) Chemical genetics: Ligand-based discovery of gene function. Nature Reviews Genetics,1(2):116-25. [pubmed pdf]
Stockwell BR. (2000) Frontiers in chemical genetics. Trends in Biotechnology, 18(11):449-55. [pubmed pdf]Stockwell BR, Haggarty SJ, and Schreiber SL. (1999) High-throughput screening of small molecules in miniaturized mammalian cell-based assays involving post-translational modifications. Chemistry & Biology, 6(2):71-83. [pubmed pdf]
Stockwell BR, Hardwick JS, Tong JK, and Schreiber S L. (1999) Chemical genetic and genomic approaches reveal a role for copper in specific gene activation. Journal of the American Chemical Society, 121:10662-3. [pdf]
Tan DS, Foley MA, Stockwell BR, Shair MD, and Schreiber SL. (1999) Synthesis and preliminary evaluation of a library of polycyclic small molecules for use in chemical genetic assays. Journal of the American Chemical Society, 121: 9073-87. [pdf]
Stockwell, BR and Schreiber SL. (1998) TGF-ß signaling with small molecule FKBP12 antagonists that bind myristoylated FKBP12-TGF-ß type I receptor fusion proteins. Chemistry & Biology, 5(7):385-95. [pubmed pdf]Stockwell BR and Schreiber SL. (1998) Probing the role of homomeric and heteromeric receptor interactions in TGF-ß signaling using small molecule dimerizers. Current Biology, 8(13): 761-70. [pubmed pdf]
Muzio M, Stockwell BR, Stennicke HR, Salvesen GS, and Dixit, VM. (1998) An induced proximity model for caspase-8 activation. Journal of Biological Chemistry, 273(5):2926-30. [pubmed pdf]
Morgan B, Stockwell BR, Dodds DR, Andrews DR, Sudhakar AR, Nielson CM, Mergelsberg I, and Zumbach A. (1997) Chemoenzymatic approaches to SCH 56592, a new azole antifungal. Journal of the American Oil Chemists' Society, 74:1361-70. [abstract]
