Journal Club Readings
Links will open appropriate .pdf files.

“We chose colonies, instead of liquid cultures, because the primary natural E. coli habitat is the gut of warm-blooded animals, where it can be found in tightly packed communities.”
from Bjedov et al. paper discussed June 3

June 3 – Barrett –Stress!

Reading 1. Bjedov I, Tenaillon O, Gerard B, Souza V, Denamur E, Radman M, Taddei F, Matic I. Stress-induced mutagenesis in bacteria. Science. 2003 May 30;300(5624):1404-9

June 10 – Sam – Blood!

Reading 1. Weinstein DA, Roy CN, Fleming MD, Loda MF, Wolfsdorf JI, Andrews NC. Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease. Blood. 2002 100:3776-3781.

Reading 2. Nicolas G, Bennoun M, Porteu A, Mativet S, Beaumont C, Grandchamp B, Sirito M, Sawadogo M, Kahn A, Vaulont S. Severe iron deficiency anemia in transgenic mice expressing liver hepcidin. Proc Natl Acad Sci U S A. 2002. 99: 4596-4601

Background. Basic hematopoiesis from the U of Virginia.

June 17 – Roy – Lasers!

News and Views: Henry C. Kapteyn and Todd Ditmire. Ultraviolet Upset. Nature 420, 5 Dec 2002: 467-468. (Note from Lora: “Lazer?” What’s with that?!)

Reading 1. Richard Neutze, et al. Potential for biomolecular imaging with femtosecond X-ray pulses. Nature 406, August 17 2000. p. 752-757. (Note from Roy: A computer simulation of what might happen to a protein hit by an intense beam of x-ray laser)

Reading 2. H. Wabnitz, et al. Multiple ionization of atom clusters by intense soft X-rays from a free-electron laser spectrometer. Nature 420, December 5 2002. p. 482-485. (Note from Roy: Hey! Actual data!)

“For the masochist…”

A free electron laser review. Patrick G. O’Shea and Henry P. Freund. Free-Electron Lasers: Status and Applications. Science 292 June 8 2001 p. 1853-1860.

And another wonderful simulation with wonderful potential: Miao, et al. "An approach to three-dimensional structures of biomolecules by using single-molecule diffraction images." PNAS 98 (12) June 5, 2001. p. 6641-6645.

June 24 – Syuzo – Stem cells and cloning troubles

Reik W, Dean W. Gene expression: Silent clones speak up. Nature. 2003 May 22;423(6938):390-1.

Boiani M, Eckardt S, Scholer HR, McLaughlin KJ. Oct4 distribution and level in mouse clones: consequences for pluripotency. Genes Dev. 2002 May 15;16(10):1209-19.

And a short comment on the above is here.

Bortvin A, Eggan K, Skaletsky H, Akutsu H, Berry DL, Yanagimachi R, Page DC, Jaenisch R. Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei. Development. 2003 Apr;130(8):1673-80.

July 1 – Lora – Human mating decisions

Reading 1. Gislen et al. Superior underwater vision in a human population of sea gypsies. Current Biology May 13, 2003; 13:833.

Reading 2. Singh and Bronstad. Female body odor is a potential clue to ovulation. Proc R Soc Lond B 2001; 268: 797.

Reading 3. Pawlowski. Variable preferences for sexual dimorphism in height as a strategy for increasing the pool of potential partners in humans. Proc R Soc Lond B 2003; 270: 709.

July 8 – Emily – Prion Madness!

Minireview Priola SA, Chesebro B, Caughey B. Biomedicine. A view from the top--prion diseases from 10,000 feet. Science. 2003 May 9;300(5621):917-9.

Reading 1 Ma J, Wollmann R, Lindquist S. Neurotoxicity and neurodegeneration when PrP accumulates in the cytosol. Science. 2002 Nov 29;298(5599):1781-5.

Reading 2 Drisaldi B, Stewart RS, Adles C, Stewart LR, Quaglio E, Biasini E, Fioriti L, Chiesa R, Harris DA. Mutant PrP Is Delayed in Its Exit from the Endoplasmic Reticulum, but Neither Wild-type nor Mutant PrP Undergoes Retrotranslocation Prior to Proteasomal Degradation. J Biol Chem. 2003 Jun 13;278(24):21732-43.

July 15 – no meeting

July 22 – Adelene – Y chromosome madness!

Minireview. Hawley RS. The human Y chromosome: rumors of its death have been greatly exaggerated. Cell. 2003 Jun 27;113(7):825-8

Reading. Rozen S, Skaletsky H, Marszalek JD, Minx PJ, Cordum HS, Waterston RH, Wilson RK, Page DC. Abundant gene conversion between arms of palindromes in human and ape Y chromosomes. Nature. 2003 Jun 19;423(6942):873-6.

July 29 – Roy – Ant madness!

Minireview. MANDYAM V. SRINIVASAN. Animal navigation: Ants match as they march. Nature 392, 660 - 661 (1998).

Reading. S. P. D. JUDD AND T. S. COLLETT. Multiple stored views and landmark guidance in ants. Nature 392, 710 - 714 (1998).

August 5 -- TBA

August 12 -- TBA

August 17 – TBA

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