July 1 -- Tim and Charles -- tissue engineering, bone growth,
telomerase, and vector-averaged gravity
Primary
1: Shi S et al. Bone formation by human postnatal bone marrow stromal stem
cells is enhanced by telomerase expression. Nature Biotechnology 2002
June;20:587.
Primary
2: Kanematsu M, Yoshimura K, Takaoki M, Sato A. Vector-averaged gravity
regulates gene expression of receptor activator of NF-kB (RANK) ligand and
osteoprotegerin in bone marrow stromal cells via cyclic AMP/protein kinase A
pathway. Bone 2002 April;30(4):553.
At
least read the News and Views! Tuan R. Boning up on telomerase. Nature
Biotechnology 2002 June;20:560.
July 8 -- Mary Ann and Steve -- Fly debauchery
Primary 1:
Moore MS et al. Ethanol intoxication in Drosophila: genetic and pharmacological
Evidence for regulation by the cAMP signaling pathway. Cell 1998; 93:
997.
Primary
2: Yao et al. beta-gamma dimers mediate synergy of dopamine D2 and adenosine
A2 receptor-stimulated PKA signaling and regulate ethanol consumption. Cell
2002; 109: 733.
At least read the
minireview! Bellen H. The fruit fly: a model organism to study the genetics
of alcohol abuse and addiction? Cell 1998; 93: 909.
July 15 -- Roy and Barrett -- Nuclear RNA processing Primary 1: Iborra et al. Coupled transcription and translation within nuclei of mammalian cells. Science 2001; 293: 1139.
Primary 2: Mukherjee et al. The mammalian exosome mediates the efficient degradation of mRNAs that contain AU-rich elements. EMBO Journal 2002; 21: 165.
For heaven's sake, at least read the minireview! Moore, M. Nuclear RNA turnover. Cell 2002; 108: 431
July 29 -- Saba and Vasu Primary 1: Schultes and Bartel. One Sequence, Two Ribozymes: Implications for the Emergence of New Ribozyme Folds. Science 289: 448.
Primary 2: Tumour regression by targeted gene delivery to the Neovasculature. John D. Hood, Mark Bednarski, Ricardo Frausto, Samira Guccione, Ralph A. Reisfeld, Rong Xiang, and David A. Cheresh. Science 2002 Jun 28 296(5577):2404-7
August 5 -- Melissa and Lora -- Gene expression profiling: SAGE
for gene discovery, and single-cell expression.
Primary 1:
Single-Cell Gene Expression Profiling. Jeffrey M. Levsky, Shailesh M. Shenoy,
Rossanna C. Pezo, and Robert H. Singer. Science Aug 2 2002: 836-840.
Primary 2:
A Phosphatase Associated with Metastasis of Colorectal Cancer. Saurabh Saha,
Alberto Bardelli, Phillip Buckhaults, Victor E. Velculescu, Carlo Rago, Brad St.
Croix, Katharine E. Romans, Michael A. Choti, Christoph Lengauer, Kenneth W.
Kinzler, and Bert Vogelstein. Science Nov 9 2001: 1343-1346.
SAGE
minireview for primary 2: Velculescu VE, Vogelstein B, Kinzler KW. Analysing
uncharted transcriptomes with SAGE. Trends Genet 2000 Oct;16(10):423-5.
August 12 -- Roy and Andrew -- Neuroregeneration
Minireview
for primary 1: Wickelgren I. Neuroscience. Animal studies raise hopes for
spinal cord repair. Science. 2002 Jul 12;297(5579):178-81.
Primary
1: Wang KC, Koprivica V, Kim JA, Sivasankaran R, Guo Y, Neve RL, He Z.
Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits
neurite outgrowth. Nature. 2002 Jun 27;417(6892):941-4.
Primary
2: Qiu J, Cai D, Dai H, McAtee M, Hoffman PN, Bregman BS, Filbin MT. Spinal
axon regeneration induced by elevation of cyclic AMP. Neuron. 2002 Jun
13;34(6):895-903.
Coincidence?
I hope this guy does not need any neurons regenerated.
August 19 -- Erna and Margie -- Caffeine and mice News
and views for primary 1: Vaugeois J-M. Signal transduction: Positive
feedback from coffee. Nature 2002 Aug 15;418(6899):734-6.
Primary
1: Lindskog M, Svenningsson P, Pozzi L, Kim Y, Fienberg AA, Bibb JA,
Fredholm BB, Nairn AC, Greengard P, Fisone G. Involvement of DARPP-32
phosphorylation in the stimulant action of caffeine. Nature 2002 Aug
15;418(6899):774-8.
News and Views for
primary 2: Snyder SH. Adenosine receptors. Knockouts anxious for new
therapy. Nature 1997 Aug 14;388(6643):624.
Primary 2: Ledent
C, Vaugeois JM, Schiffmann SN, Pedrazzini T, El Yacoubi M, Vanderhaeghen JJ,
Costentin J, Heath JK, Vassart G, Parmentier M. Aggressiveness, hypoalgesia and
high blood pressure in mice lacking the adenosine A2a receptor. Nature 1997 Aug
14;388(6643):674-8.
August 26 -- Corey and Someone else???
-- Watch this space!
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back to the schedule.
Note: The
Nature website is a little temperamental and the .pdfs would not load for me. If
they don't work for you right away, try back in a few hours. Grrr! Bad
Nature!!!