Biological Sciences Columbia University
FACULTYRESEARCHPh.D. PROGRAMM.A. BIOTECHNOLOGYUNDERGRADUATECOURSES
Ph.D. Program Faculty
Research Highlights
Postdoctoral Research
Research Highlights

The Research Highlights section features the most recent research going on in the Dept. Check back regularly for updates to this information.

Combined deficiency of p50 and cRel in CD4+ T cells reveals an essential requirement for nuclear factor kappaB in regulating mature T cell survival and in vivo function.
Amer Beg (Professor)

Research Summary

Checkpoint kinase 2 (Chk2) monomers or dimers phosphorylate Cdc25C after DNA damage regardless of threonine 68 phosphorylation
Carol Prives (Professor)

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Cyclin G recruits PP2A to dephosphorylate Mdm2
Carol Prives (Professor)

Research Summary

Alteration of the C-terminal amino acid of tubulin specifically inhibits myogenic differentiation.
Chloë Bulinski (Professor)

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Hedgehog acts as a somatic stem cell factor in the Drosophila ovary
Daniel Kalderon (Professor)

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REDUCE: an online tool for inferring cis-regulatory elements and transcriptional module activities from microarray data
Harmen Bussemaker (Professor)

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Genomewide analysis of Drosophila GAGA factor target genes reveals context-dependent DNA binding
Harmen Bussemaker (Professor)

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Strange bedfellows: polyadenylation factors at the promoter.
James Manley (Professor)

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A negative element in SMN2 exon 7 inhibits splicing in spinal muscular atrophy.
James Manley (Professor)

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Dual regulation of voltage-gated calcium channels by PtdIns(4,5)P2.
Jian Yang (Professor)

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Reverse engineering of the giant muscle protein titin
Julio Fernández (Professor)

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Lawrence Chasin (Professor)

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The effect of nonsense codons on splicing: A genomic analysis
Lawrence Chasin (Professor)

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Crystal structure of carnitine acetyltransferase and implications for the catalytic mechanism and fatty acid transport
Liang Tong (Professor)

Research Summary

Crystal structure of the BEACH domain reveals an unusual fold and extensive association with a novel PH domain
Liang Tong (Professor)

Research Summary

Crystal structure of the carboxyltransferase domain of acetyl-coenzyme A carboxylase
Liang Tong (Professor)

Research Summary

Dp1 is required for extra-embryonic development
Lili Yamasaki (Professor)

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The mechanosensory protein MEC-6 is a subunit of the C. elegans touch-cell degenerin channel.
Martin Chalfie (Professor)

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RPTP-alpha acts as a transducer of mechanical force on alphav/beta3-integrin-cytoskeleton linkages
Michael Sheetz (Professor)

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Two-piconewton slip bond between fibronectin and the cytoskeleton depends on talin
Michael Sheetz (Professor)

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Single pilus motor forces exceed 100 pN
Michael Sheetz (Professor)

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Attractor dynamics of network UP states in the neocortex
Rafael Yuste (Professor)

Research Summary

How the Unconscious Shapes Modern Science
Robert Pollack (Professor)

Research Summary
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