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My major was in Chemistry (2004), but recently I
became very interested in neuroscience. This may sound odd, just as though
being Brazilian I can't dance samba or play soccer well. Actually, I majored in
Chemistry to acquire a solid basis in the physical sciences, which will help me
to do research in modern Biology.
I started to work in neuroscience with Prof.
Etelvino J. H. Bechara in the University
of Sao Paulo, in which we
studied the neurotoxic effects of lead poisoning.
During this project my interest in neuroscience
grew partly because I think that this field will, eventually, provide us with a
profound understanding of ourselves, because all of our hopes and miseries are
but a consequence of the activity of our brains.
Currently at Columbia
I am studying how different areas of the brain communicate with each other
during anxiety in mice. So far we found that anxiety increases synchronization
between the prefrontal cortex and the hippocampus in both genetic and
behavioral models of anxiety in mice.
During my free time, if I have any, I will continue
to compose songs, draw sketches, go out with friends and play mediocre soccer.
I also hope I am going to have the time and energy (and the money as well!) to
enjoy what Columbia
and NYC have to offer.
Publications
Intracellular Ca2+ Regulation During Neuronal Differentiation of Murine
Embryonal Carcinoma and Mesenchymal Stem Cells. Resende RR, da Costa JL, Kihara
AH, Adhikari A, Lorençon E, Britto LR. Stem Cells Dev. 2008 Nov 25.
Mechanism of acetylcholine-induced calcium signaling during neuronal
differentiation of P19 embryonal carcinoma cells in vitro. Resende RR, Gomes
KN, Adhikari A, Britto LR, Ulrich H. Cell Calcium. 2008;43(2):107-21.
The dual face of endogenous alpha-aminoketones: pro-oxidizing metabolic
weapons.Bechara EJ, Dutra F, Cardoso VE, Sartori A, Olympio KP, Penatti CA,
Adhikari A, Assunção NA. Comp Biochem Physiol C Toxicol Pharmacol.
2007;146(1-2):88-110.
5-Aminolevulinate and 4, 5-dioxovalerate ions decrease GABA(A) receptor
density in neuronal cells, synaptosomes and rat brain. Adhikari A, Penatti CA,
Resende RR, Ulrich H, Britto LR, Bechara EJ. Brain Res. 2006; 1093(1):95-104.
International Conference Proceedings:
- "Oxidative Damage of GABAa Receptors by
5-Aminolevulinate" - A. Adhikari, C. A. A. Penatti, L.R. G. Britto and E.
J. H. Bechara - Free Radical Biology and Medicine, 36, Suppl. 1, S89 (2004).
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