My main research goal is to relate the physics of cell movement to the underlying biochemical mechanisms. I have developed tools for measuring the velocity of membrane protrusions and retractions during the process of cell spreading. Correlating the velocity of membrane movement tobiochemical manipulations of the cytoskeleton and its regulators has allowed us to start unraveling the details of the motility machinery driving eukaryotic cell movement. My present work focuses on developing quantitative correlations between velocity and fluorescence intensity as well as observing the effects on membrane velocity of sub-cellular manipulations of key biochemical regulators.

MedLine Listing of Ben Dubin-Thaler's Publications