Directory of Classes

NOTE: Course information changes frequently, including Methods of Instruction. Please revisit these pages periodically for the most recent and up-to-date course information.

Spring 2022 Biology GU4002 section 001
Macromolecular Structure & Interactions
Macromol Structure & Inte

Call Number 14036
Day & Time
MW 10:10am-11:25am
601 Sherman Fairchild Life Sciences Building
Points 4
Grading Mode Standard
Approvals Required None
Instructor John Hunt - e-mail, homepage
Method of Instruction In-Person
Course Description This course has three interrelated goals: (i) to develop an intuitive understanding of the thermodynamic forces that control the structure of biological macromolecules and the evolution of life, (ii) to learn how to apply that understanding to experimental analyses of macromolecular interactions, and (iii) to master the use of molecular graphics software for understanding and interpreting macromolecular structures and interactions. The lectures develop the essential thermodynamic theory from the ground up, starting from a review of the relevant physical forces (Newton's and Coulomb's Laws) and culminating with an intuitive explanation of how complex biological organisms can evolve spontaneously, in a universe in which all natural processes are driven by increasing randomness or entropy, as specified by the 2nd Law of Thermodynamics. Subsequent lectures elaborate how these thermodynamic principles govern the formation and interaction of macromolecular structures, which represent the physical foundation for the evolution of life, and how the same principles are applied to analyze related experimental data. The problem sets for the course focus on practical applications of these principles to the analysis of data from common experiments used by molecular biologists to characterize macromolecular interactions. Extensive use is made of molecular graphics software throughout the semester, including in the problem sets, based on instruction provided in both the lectures and recitation sections. The course is designed to develop a deep understanding of the physical mechanisms controlling macromolecular interactions while simultaneously empowering students to critically read related literature and rigorously design and analyze related experiments themselves.
Web Site Vergil
Department Biological Sciences
Enrollment 9 students (25 max) as of 8:02AM Wednesday, July 6, 2022
Subject Biology
Number GU4002
Section 001
Division Interfaculty
Campus Morningside
Note Molecular biophysics for undergrads & mol bio grad students
Section key 20221BIOL4002W001

Home      About This Directory      Online Bulletins      ColumbiaWeb      SSOL
SIS update 07/06/22 08:02    web update 07/06/22 09:31