Kevin D. Costa

Associate Professor, Department of Biomedical Engineering

Education
B.S., Biomedical Engineering, Boston University, 1988
M.S., Biomedical Engineering, Boston University, 1990
Ph.D., Bioengineering, University of California San Diego, 1996
Postdoctoral Fellow, The Johns Hopkins University, 1996-1997
Postdoctoral Fellow, Washington University, 1997-1999

Research Summary
In the Cardiac Cell Mechanics Laboratory we study constitutive modeling, cell and tissue adaptation to mechanical loading, and development of myocardial tissue architecture. Equipment includes cell and tissue culture facilities, cell stretch and shear devices, a customized atomic force microscope, a digital real-time confocal fluorescence microscope, and Silicon Graphics workstations for computational modeling. The lab is part of the Cardiac Biomechanics Group at Columbia University, which has the capabilities to perform experiments from the level of individual cells, to isolated muscle strips, to engineered tissues, to whole hearts in animals and humans.

Recent Publications
Kuncicky DM, Bose K, Costa KD, Velev OD. Sessile droplet templating of miniature porous hemispheres from colloid crystals. Chem Mater, 19:141-143, 2007.

Ateshian GA, Costa KD, Hung CT. A theoretical analysis of water transport through chondrocytes. Biomechan Model Mechanobiol, 6:91-101, 2007.

Guo XE, Takai E, Jiang XJ, Xu Q, Whitesides GM, Yardley JT, Hung CT, Chow E, Costa KD. Intracellular calcium waves in bone cell networks under single cell nanoindentation. Mol Cell Biomech, 3:95-107, 2006.

Costa KD. Imaging and probing cell mechanical properties with the atomic force microscope. Methods Mol Biol, 319:331-361, 2006.

Costa KD, Sim, AJ, Yin FCP. Non-Hertzian approach to analyzing mechanical properties of endothelial cells probed by atomic force microscopy. J Biomech Eng, 128:176-184, 2006.

Teaching
BMEN E3310 Solid Biomechanics -- Spring '00, '01
BMEN E3320 Fluid Biomechanics -- Spring '06, '07
BMEN E3001 Quantitative Physiology -- Fall '01, '02, '03
BMEN E3840 Biomedical Engineering Lab IV -- Spring '00 - '05
BMEN E3830 Biomedical Engineering Lab III -- Fall '00
BMEN E4340 Biomechanics of Cells -- Spring '01, '03, '05