Jeffrey W. Holmes

Associate Professor, Department of Biomedical Engineering

Education
B.S., Biomedical Engineering, The Johns Hopkins University, 1989
Ph.D., Bioengineering, University of California San Diego, 1995
M.D., Medicine, University of California San Diego, 1998
Postdoctoral Fellow, Cardiology, University of Freiburg, 1995-1996
Postdoctoral Fellow, Developmental Biology, University of South Carolina, 1998-1999

Research Summary
The Cardiac Tissue Mechanics Laboratory is part of the Cardiac Biomechanics Group at Columbia University. Our central areas of research are structure-function relationships in failing myocardium and myocardial scar tissue, response of cardiac myocytes and fibroblasts to mechanical overload, and noninvasive diagnosis of mechanical dysfunction. The laboratory includes facilities for short- and long-term study of isolated muscles, loaded and unloaded culture of cardiac fibroblasts, and finite element modeling of the heart.

Recent Publications

Costa KD, Lee EJ, Holmes JW. Creating alignment and anisotropy in engineered heart tissue: role of boundary conditions in a model three-dimensional culture system. Tissue Engineering Aug;9(4):567-577, 2003.

Holmes JW. Determinants of left ventricular shape change during filling. J Biomech Eng 126(1):98-103, 2004

Holmes JW. Candidate mechanical stimuli for hypertrophy during volume overload. J Appl Physiol 97:1453-1460, 2004. (First published online May 28, 2004; doi:10.1152/ japplphysiol.00834.2003)

Holmes JW, Borg TK, Covell JW. Structure and mechanics of healing myocardial infarcts. Annu Rev Biomed Eng 7:223-253, 2005. (First published online February 22, 2005; doi:10.1146/annurev.bioeng.7.060804.100453)

Herz SL, Ingrassia CM, Homma S, Costa KD, Holmes JW. Parameterization of left ventricular wall motion for detection of regional ischemia. Ann Biomed Eng 33(7):920-927, 2005.

Angelini ED, Homma S, Pearson G, Holmes JW, Laine AF. Segmentation of real-time three-dimensional ultrasound for quantification of ventricular function: a clinical study on right and left ventricles. Ultrasound Med Biol 31(9):1143-1158, 2005.

Thomopoulos S, Holmes JW. The development of structural and mechanical anisotropy in fibroblast populated collagen gels. J Biomech Eng 127(5):742-750, 2005.

Teaching
BMEN E3320 Fluid Biomechanics -- Spring 2000–2005
BMEN E4010 Ethics for Biomedical Engineers -- Spring '00,'01; Fall '01, '04, '05
BMEN E4305 Cardiac Mechanics -- Fall 2000, 2002; Spring 2006