Cardiac Biomechanics Group at Columbia University

Publications

Structure and mechanics of healing myocardial infarcts. Ann Rev Biomed Eng

Parameterization of left ventricular wall motion... Ann Biomed Eng

Determinants of left ventricular shape change... J Biomech Eng

Creating alignment and anisotropy in engineered heart tissue... Tissue Eng

Stress fibers buckle in rapidly shortened cells... Cell Motil Cytoskel

Isotonic biaxial loading of fibroblast-populated... Biomech Model Mechanobiol

Normalized diastolic properties after left ventricular assist... Circulation

Modeling cardiac mechanical properties in three dimensions. Phil Trans Royal Soc Lond A

Determinants of left ventricular shape change during filling.

J Biomech Eng. 2004 Feb;126(1):98-103.
Holmes JW.

Left ventricular shape and shape change are easy to measure and their analysis has been proposed as a noninvasive method to determine myocardial anisotropy. In preparation for applying this approach to studies of rats with experimentally induced cardiac hypertrophy, the goals of this study were to describe normal shape changes during diastolic filling in the rat and to utilize a finite element model to estimate the relative importance of three factors that determine left ventricular shape change during filling: global chamber compliance, fiber to crossfiber stiffness ratio, and fiber architecture. The results suggest that left ventricular shape change is least sensitive to fiber to crossfiber stiffness ratio, and that this will likely limit the practical utility of using shape changes to diagnose changes in myocardial anisotropy.

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