Scott A. Banta
820 Mudd, Mail Code: 4721
Phone: +1 212-854-7531
Fax: +1 212-854-3054
Ph.D., Chemical Engineering, Rutgers University, 2002
M.S., Chemical Engineering, Rutgers University, 2000
B.S.E, Chemical Engineering, University of Maryland, Baltimore County, 1997.
Our research focuses on applying
protein engineering and metabolic engineering tools to solve a variety of important
problems in bioengineering. Protein engineering involves the modification of
proteins and peptides in order to produce new molecules with novel traits or
functions. Metabolic engineering refers to the characterization and improvement
of networks of enzymes to obtain desired new goals. These pursuits can be used
to bring about new solutions to problems in biotechnology, nanotechnology,
biomedical engineering, bioprocess engineering, and drug discovery.
One of our current research interests involves the engineering of peptide conformational changes. Peptide motifs have been evolved to respond to changes in their environment through alterations in their corresponding structures.We are interested in engineering new stimulus-responsive peptides that respond to novel environmental cues.These new peptides will be useful in many applications including tissue engineering, protein purification, bioremediation, drug delivery, and bionanotechnology.
Another area of interest is the engineering of peptides for targeted drug delivery. A new class of peptides has recently been discovered that are capable of directing the transport of materials across cellular membranes but they lack cell type specificity.We are engineering new peptides that are specific for different tissues and organs. For example, peptides that can cross the blood brain barrier and target specific brain cell populations will be valuable for the treatment of several central nervous system disorders.
Campbell, E., Meredith, M., Minteer, S.D., and Banta, S. (2012) "An Enzymatic biofuel cell utilizing a biomimetic cofactor" Chemical Communications 48(13) 1898-1900.
Holland, J.T., Lau, C., Brozik, S., Atanassov, P., and Banta, S., (2011) "Protein engineering of a glucose oxidase for direct electron transfer via targeted gold nanoparticle conjugation" Journal of the American Chemical Society 133(48) 19262-19265.
Wu, J., Park, J.P., Dooley, K., Cropek, D.M., West, A.C. and Banta, S. (2011) "Rapid development of new protein biosensors utilizing peptides obtained via phage display" PLoS ONE 6(10) 1-9.
Felsovalyi, F., Mangiagalli, P., Bureau, C., Kumar, S.K., and Banta, S. (2011) "Reversibility of the adsorption of lysozyme on silica" Langmuir 27(19) 11873-11882.
Gao, S., Simon, M.J., Hue, C.D., Morrison III, B., and Banta, S. (2011) "An unusual cell penetrating peptide identified using a plasmid display-based functional selection platform" ACS Chemical Biology 6(5) 484-491.