“Polyfunctional Zinc and Magnesium Organometallics for Organic Synthesis”
Presented by Professor Paul Knochel, Ludwig-Maximilians Universität
Hosted by: Prof. James Leighton
In the first part of the lecture, the preparation of highly functionalized organozinc compounds will be emphasized using zinc powder in the presence of LiCl.1 This method allows the preparation of a range of heteroarylzinc species bearing a ketone or an aldehyde. In a second part, the preparation of polyfunctional magnesiated heterocycles using either a X/Mg- exchange triggered by i-PrMgCl-LiCl or by a direct deprotonation using new soluble Mg-bases such as TMPMgCl-LiCl or (TMP)2Mg-2LiCl.2 Applications of these polyfunctional organometallics for the synthesis of bioactive molecules will be shown.3 Finally, the synthesis of aminated heterocycles using an oxidative amination procedure with chloranil will be described.4
Tea & cookies at 4:00pm in The Miller Seminar Room 328 Havemeyer Hall
Seminar at 4:30pm in The Brian Bent Memorial Lecture Hall Room 209 Havemeyer Hall
