The Ramabrahman and Balamani Guthikonda Award Lecture
“Chemistry and Catalysis in Chiral, Nanoscale Flasks”
Presented by Prof. Ken Raymond, University of California-Berkeley
We
form nanometer scale molecular flasks using labile metal-ligand interactions.
Most of the clusters are highly negatively charged and very water-soluble.
However they have hydrophobic interiors that strongly and selectively
encapsulate hydrophobic cationic guests. Because of trigonal propeller
chirality at the metal vertices and mechanical linkage between the metal
vertices, these clusters are homochiral and resolvable. Catalyst guests operate
within the flasks, enabling chiral recognition and catalytic turnover.
Selective encapsulation of a specific conformer or protonated substrate guest
leads to enzyme-like catalysis of up to 3 to 4 orders of magnitude.
Hosted by Prof. Gerard Parkin
Thursday, May 22, 2008
Meet the speaker at 1:30pm
The Miller Seminar Room, 328 Havemeyer Hall
Tea and cookies at 4:00pm
The Miller Seminar Room, 328 Havemeyer Hall
Lecture at 4:30pm
The Brian Bent Memorial Lecture Hall, Room 209 Havemeyer Hall
