The overarching goal of the Reisman laboratory is to discover, develop, and study new chemical reactions within the context of natural product total synthesis. To this end, our laboratory has several ongoing research programs targeting the total synthesis of biologically active alkaloid and diterpenoid natural products, as well as projects in the area of asymmetric catalysis. This seminar will describe our recent progress in these endeavors, including the development and application of new catalytic enantioselective methods to prepare pyrroloindolines, as well as studies in the synthesis of norcaradienes through arene cyclopropanation reactions.