Columbia University, Department of Chemistry
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New York, NY 10027
212-854-1438
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Research Summary
Research in the Lambert Group is focused on challenging the paradigm of iterative synthesis for the preparation of complex molecules. A major objective of this program is to advance strategies that achieve rapid generation of molecular complexity via the prosecution of multiple distinct catalytic cycles in a single reaction vessel, an area of research termed multicatalysis. In these endeavors, we aim (1) to invent new chemical technologies that are amenable to incorporation in multicatalytic processes, and (2) to develop versatile multicatalytic strategies that allow for the preparation of biologically relevant organic architectures with unprecedented efficiency.
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"Multicatalytic Synthesis of Complex Tetrahydrofurans Involving Bismuth(III) Triflate-Catalyzed Intramolecular Hydroalkoxylation of Unactivated Olefins,"Kelly, B. D.; Allen, J. M.; Tundel, R. E.; Lambert, T. H., Org. Lett. (2009)
"Multicatalytic Synthesis of a-Pyrrolidinyl Ketones via a Tandem Palladium(II)/In(III)-Catalyzed Aminochlorocarbonylation/Friedel-Crafts Acylation Reaction," Cernak, T. A.; Lambert T. H., J. Am. Chem. Soc. (2009)
"Development of a Formal [4+1] Cycloaddition: Pd(OAc)2-Catalyzed Intramolecular Cyclopropanation of 1,3-Dienyl b-Keto Esters and MgI2-Promoted Vinylcyclopropane-Cyclopentene Rearrangement," Coscia, R. W.; Lambert, T. H., J. Am. Chem. Soc. (2009)
“Total Synthesis of UCS1025A,” Lambert T. H.; Danishefsky, S. J., J. Am. Chem. Soc.128, 426 (2006)
“Olefin Cross-Metathesis:A Powerful Tool for Constructing Vaccines Composed of Multimeric Antigens,”Wan, Q.; Cho, Y. S.; Lambert, T. H.,J. Carbohydrate Chem. 24, 425 (2005)
“Development of a New Lewis Acid-Catalyzed [3,3]-Sigmatropic Rearrangement:The Allenoate-Claisen Rearrangement,” Lambert, T. H.; MacMillan, D. W. C., J. Am. Chem. Soc. 124, 13646 (2002)
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