Publications

At Columbia:

L. Wei and W. Min. "Pump-probe optical microscopy for imaging non-fluorescent chromophores", Anal. Bioanal. Chem.  (2012) in press

L. Wei, Z. Chen and W. Min. "Stimulated emission reduced fluorescence microscopy: a concept for extending the fundamental depth limit of two-photon fluorescence imaging", Biomed. Opt. Express 3, 1465 (2012)

Y.-T. Kao, X. Zhu and W. Min. "Protein flexibility mediated coupling between photoswitching kinetics and the surrounding viscosity of a photochromic fluorescent protein", Proc. Natl. Acad. Sci. USA, 109, 3220 (2012).

W. Min. "Label-free optical imaging of non-fluorescent molecules by stimulated radiation",  Curr. Opin. Chem. Biol., 15, 831, (2011).

X. Zhu and W. Min. "Frequency-domain phase fluorometry in the presence of dark states: a numerical study", Chem. Phys. Lett., 516, 40, (2011).

A. Folick, W. Min and M. C. Wang. "Label-free imaging of lipid dynamics using Coherent Anti-stokes Raman Scattering (CARS) and Stimulated Raman Scattering (SRS) microscopy",  Curr. Opin. Genet. Dev., 21, 1 (2011).

E. Gatzogiannis, X. Zhu, Y.-T. Kao, W. Min. "Observation of frequency-domain fluorescence anomalous phase advance due to dark state hysteresis", J. Phys. Chem. Lett., 2, 461, (2011). 

M. C. Wang*, W. Min*, C. W. Freudiger, G. Ruvkun and X. S. Xie*. "RNAi screening for fat regulatory genes with SRS microscopy", Nature Methods, 8, 135, (2011). *Co-corresponding authors.

 

Prior to Columbia:

Optical bio-imaging:

W. Min, C. W. Freudiger, S. Lu and X. S. Xie. "Coherent nonlinear optical imaging: Beyond fluorescence microscopy", Annu. Rev. Phys. Chem., 62, 506, (2011).

C. W. Freudiger, W. Min, G. R. Holtom, B. Xu, M. Dantus and X. S. Xie. "Highly specific label-free molecular imaging with spectrally tailored excitation stimulated Raman scattering (STE-SRS) microscopy", Nature Photonics, 5, 103, (2011).

S. Chong*, W. Min* and X. S. Xie. "Ground-state depletion microscopy: detection sensitivity of single-molecule optical absorption at room temperature", J. Phys. Chem. Lett., 1, 3316, (2010). *equal contribution.

S. Lu*, W. Min*, S. Chong, G. H. Holtom and X. S. Xie. “Label-free imaging of heme
proteins with two-photon excited photothermal lens microscopy”, Appl. Phys. Lett., 96,113701, (2010). *equal contribution.

W. Min*, S. Lu*, S. Chong, R. Rahul, G. H. Holtom and X. S. Xie. “Imaging chromophores
with undetectable fluorescence by simulated emission microscopy”, Nature, 461, 1105, (2009).
*equal contribution.

W. Min*, S. Lu*, M. Rueckel,. G. R. Holtom and X. S. Xie. “Near-degenerate four-wave-
mixing microscopy”, Nano Lett., 9, 2423, (2009). *equal contribution.

W. Min, S. Lu, G. R. Holtom and X. S. Xie. “Triple-resonance coherent anti-Stokes Raman
scattering microspectroscopy”, ChemPhysChem, 10, 344, (2009).

J. Lu*, W. Min*, J.-A. Conchello, X. S. Xie and J. W. Lichtman. “Super-resolution laser
scanning microscopy through spatio-temporal modulation”, Nano Lett., 9, 3883, (2009). *equal
contribution.

C. W. Freudiger*, W. Min*, B. G. Saar, S. Lu, G. R. Holtom, C. He, J. C. Tsai, J. X. Kang
and X. S. Xie. “Label-free biomedical imaging with high sensitivity by stimulated Raman
scattering microscopy”, Science, 322, 1857, (2008). *equal contribution.

Single-molecule enzyme biophysics:

W. Min, L. Jiang and X. S. Xie. “Complex kinetics of fluctuating enzymes: phase diagram characterization of a minimal kinetic scheme”, Chem.-Asian J. 5, 1129, (2010).

W. Min, X. S. Xie and B. Bagchi. “Role of conformational dynamics in kinetics of an
enzymatic cycle in a non-equilibrium steady state”, J. Chem. Phys., 131, 065104, (2009).

W. Min, X. S. Xie and B. Bagchi. “Two-dimensional reaction free energy surfaces of
catalytic reaction: effects of protein conformational dynamics on enzyme catalysis”, J. Phys.
Chem. B, 112, 454, (2008).

W. Min, I. V. Gopich, B. P. English, S. C. Kou, X. S. Xie and A. Szabo. “When does the
Michaelis-Menten equation hold for fluctuating enzymes?”, J. Phys. Chem. B, 110, 20093,
(2006).

B. P. English, W. Min, A. M. van Oijen, K. T. Lee, G. Luo, H. Sun, B. J. Cherayil, S. C. Kou
and X. S. Xie. “Ever-fluctuating single enzyme molecules: Michaelis-Menten equation revisited”,
Nat. Chem. Biol. 2, 87, (2006) (Coverpage).

W. Min and X. S. Xie. “Kramers model with a power-law friction kernel: dispersed kinetics
and dynamic disorder of biochemical reactions”, Phys. Rev. E, 73, 010902, (2006).

W. Min, L. Jiang, J. Yu, S. C. Kou, H. Qian and X. S. Xie. “Non-equilibrium steady state of a
nanometric biochemical system: determining the thermodynamic driving force from single
enzyme turnover time traces”, Nano Lett., 5, 2373, (2005).

W. Min, B. P. English, G. Luo, B. J. Cherayil, S. C. Kou and X. S. Xie. “Fluctuating
enzymes: lessons from single-molecule studies”, Acc. Chem. Res., 38, 923, (2005).

P. Debnath, W. Min, X. S. Xie and B. J. Cherayil. “Multiple time scale dynamics of distance
fluctuations in a semiflexible polymer: a one-dimensional generalized Langevin equation
treatment”, J. Chem. Phys., 123, 204903, (2005).

S. C. Kou, B. J. Cherayil, W. Min, B. P. English and X. S. Xie. “Single-molecule Michaelis-
Menten equations”, J. Phys. Chem. B, 109, 19068, (2005) (Coverpage).

W. Min, G. Luo, B. J. Cherayil, S. C. Kou and X. S. Xie. “Observation of a power-law
memory kernel for fluctuations within a single protein molecule”, Phys. Rev. Lett., 94, 198302,
(2005).