NMR Techniques for Structural Determination

The following techniques are implemented. They are grouped by the type of information provided. Others are available upon request.

J measurement (H-H)

• COSY-DQF
• E. COSY
• H-H Homonuclear decoupling
• Spectral simulation  (SpinWorks)

H-H spatial proximity

• NOESY-2D /w ZQ suppression
• ROESY-2D
• 1D-gradient selectived NOESY

Carbon-proton connectivity - through J coupling

• HSQC or HMQC direct correlation - one bond
• HSQC-TOCSY - carbon resolved TOCSY
• HMBC - long range correlation - 2 to 3 bond. Accordion method for reduced dependence on coupling values
• H2BC - Heteronuclear two bond correlation
• ADEQUATE - proton detected INADEQUATE- long range correlation

J measurement (C-H long range)

• Exside

Water suppression

• PURGE
  
• presaturation

Exchange - Relaxation

• 2D EXESY (NOESY)
• selective magnetization transfer 1D
• T1 measurement

Heteronuclear NMR

• NMR spectra of nuclei such as carbon, phosphorus, fluorine, deuterium, nitrogen, etc...
• DEPT

Diffusion

• diffusion measurements, size determination

Solid-State-NMR

• CP-MAS