| Jan. 2012 | The Sames group would like to welcome Madalee Gassaway to the group! |
| Sep. 2011 | We report here a new protocol for highly selective C-H arylation of pyridines containing readily available and synthetically versatile electron-withdrawing substituents. This work expands the scope of catalytic azine functionalization as well as complements existing methods for C-H arylation and Ir-catalyzed borylation of pyridines, and has been published in J. Am. Chem. Soc. [Abstract] |
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| June 2011 | The Sames group welcomes new members:
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| Feb. 2011 | Intramolecular energy transfer from carbostyril 124-sensitized Tb3+ to Eu3+ in aqueous aggregates is reported here to show the first example of imaging this phenomenon on the cellular membrane of HEK-293T cells. Our work serves as an example for the applicability of this energy transfer probe for imaging biological systems. Check out our work in Org. Lett. [Abstract] |
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| Sep. 2010 | We describe a novel optical approach for measuring the changes of metabolic fluxes in cells, based on a two-substrate competition between a physiological substrate and a fluorogenic reporter substrate. This work has been published in ACS Chem. Biol. [Abstract] |
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| July 2010 | We developed a general and comprehensive approach for the synthesis of complex aryl imidazoles, where all three C-H bonds of the imidazole core can be arylated in a regioselective and sequential manner. This work has been published as a featured article in J. Org. Chem. [Abstract] |
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| June 2010 | We introduce pH-responsive fluorescent false neurotransmitters (pH-responsive FFNs) as novel probes that act as vesicular monoamine transporter (VMAT) substrates and ratiometric fluorescent pH sensors. This work has been published in J. Am. Chem. Soc. [Abstract] |
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| Nov. 2009 | Our work on fluorescent false neurotransmitters that enabled us to observe neurotransmitter uptake and release from individual presynaptic terminals directly has been published in Journal of Visualized Experiments, a video journal for biological research. Click here to play the video. [html] |
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| Oct. 2009 | The scope of the through-space hydride transfer reactions has been expanded to include terminal alkynes as the hydride acceptors. This work has been published in J. Am. Chem. Soc. [Abstract] |
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| June 2009 | The hydride transfer initiated cyclization of aryl alkyl ethers leads to the formation of dihydrobenzopyrans. Check out our latest work on C-H bond functionalization in Org. Lett. [Abstract] [html] This article has been selected by the Editorial Board of Synfacts. [PDF] |
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| May 2009 | Our study of the nervous system using fluorescent false neurotransmitters has been published in Science. [Abstract] This work has been featured in Chemical & Engineering News. [html] This work has been also reviewed by Nature Methods [html] [pdf] and Physiology [pdf]. |
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| Feb. 2009 | The group's latest work on regioselective direct C-arylation of pyrazoles has been published in J. Am. Chem. Soc. [Abstract] |
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| Jan. 2009 | The group's latest work on C-H bond functionalization via hydride transfer has been published in J. Am. Chem. Soc. [Abstract] This article was summarized in Synfacts. [PDF] |
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| Oct. 2008 | The group's latest work on imaging induction of cytoprotective enzymes in intact human cells has appeared in J. Am. Chem. Soc. [Abstact] This article was featured as a "Spotlight" in Chemical Research in Toxicology. [Abstract] |
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| Aug. 2008 | Congratulations to Dali and Professor David Sulzer of the Department of Neuroscience on receiving a 2008-2009 McKnight Foundation Technical Innovations in Neuroscience Award for their project "Development of Fluorescent False Neurotransmitters: Novel Probes for Direct Visualization of Neurotransmitter Release from Individual Presynaptic Terminals." |
Last Updated: June 2011