Jan. 2012 The Sames group would like to welcome Madalee Gassaway to the group!
Sep. 2011 We report here a new protocol for highly selective C-H arylation of pyridines containing readily available and synthetically versatile electron-withdrawing substituents. This work expands the scope of catalytic azine functionalization as well as complements existing methods for C-H arylation and Ir-catalyzed borylation of pyridines, and has been published in J. Am. Chem. Soc. [Abstract]
 
June 2011 The Sames group welcomes new members:

  • Matthew R. Dunn - Graduate Student
  • Ekeoma C. Nwadibia - Graduate Student
  • Andrew C. Kruegel - Graduate Student
  • Dr. Souvik Rakshit - Post Doc
  • Dr. Yves Meyer - Post Doc
  • Dr. Adam Henke - Post Doc
  • Feb. 2011 Intramolecular energy transfer from carbostyril 124-sensitized Tb3+ to Eu3+ in aqueous aggregates is reported here to show the first example of imaging this phenomenon on the cellular membrane of HEK-293T cells. Our work serves as an example for the applicability of this energy transfer probe for imaging biological systems. Check out our work in Org. Lett. [Abstract]
     
    Sep. 2010 We describe a novel optical approach for measuring the changes of metabolic fluxes in cells, based on a two-substrate competition between a physiological substrate and a fluorogenic reporter substrate. This work has been published in ACS Chem. Biol. [Abstract]
     
    July 2010 We developed a general and comprehensive approach for the synthesis of complex aryl imidazoles, where all three C-H bonds of the imidazole core can be arylated in a regioselective and sequential manner. This work has been published as a featured article in J. Org. Chem. [Abstract]
     
    June 2010 We introduce pH-responsive fluorescent false neurotransmitters (pH-responsive FFNs) as novel probes that act as vesicular monoamine transporter (VMAT) substrates and ratiometric fluorescent pH sensors. This work has been published in J. Am. Chem. Soc. [Abstract]
     
    Nov. 2009 Our work on fluorescent false neurotransmitters that enabled us to observe neurotransmitter uptake and release from individual presynaptic terminals directly has been published in Journal of Visualized Experiments, a video journal for biological research. Click here to play the video. [html]
     
    Oct. 2009 The scope of the through-space hydride transfer reactions has been expanded to include terminal alkynes as the hydride acceptors. This work has been published in J. Am. Chem. Soc. [Abstract]
     
    June 2009 The hydride transfer initiated cyclization of aryl alkyl ethers leads to the formation of dihydrobenzopyrans. Check out our latest work on C-H bond functionalization in Org. Lett. [Abstract] [html] This article has been selected by the Editorial Board of Synfacts. [PDF]
     
    May 2009 Our study of the nervous system using fluorescent false neurotransmitters has been published in Science. [Abstract] This work has been featured in Chemical & Engineering News. [html] This work has been also reviewed by Nature Methods [html] [pdf] and Physiology [pdf].
     
    Feb. 2009 The group's latest work on regioselective direct C-arylation of pyrazoles has been published in J. Am. Chem. Soc. [Abstract]
     
    Jan. 2009 The group's latest work on C-H bond functionalization via hydride transfer has been published in J. Am. Chem. Soc. [Abstract] This article was summarized in Synfacts. [PDF]
     
    Oct. 2008 The group's latest work on imaging induction of cytoprotective enzymes in intact human cells has appeared in J. Am. Chem. Soc. [Abstact] This article was featured as a "Spotlight" in Chemical Research in Toxicology. [Abstract]
     
    Aug. 2008 Congratulations to Dali and Professor David Sulzer of the Department of Neuroscience on receiving a 2008-2009 McKnight Foundation Technical Innovations in Neuroscience Award for their project "Development of Fluorescent False Neurotransmitters: Novel Probes for Direct Visualization of Neurotransmitter Release from Individual Presynaptic Terminals."
       
       
    Last Updated: June 2011