Dopamine Release at Individual Presynaptic Terminals Visualized with FFNs.
Hui Zhang, Niko G. Gubernator, Minerva Yue, Roland G. W. Staal, Eugene V. Mosharov, Daniela Pereira, Vojtech Balsanek, Paul A. Vadola, Bipasha Mukherjee, Robert H. Edwards, David Sulzer, and Dalibor Sames.
Journal of Visualized Experiments. [html]

C-H Bond Functionalization via Hydride Transfer: Direct Coupling of Unactivated Alkynes and sp³ C-H Bonds Catalyzed by Platinum Tetraiodide.
Paul A. Vadola and Dalibor Sames.
J. Am. Chem. Soc. 2009, 131, ASAP. [Abstract] [Full Text-PDF]

C-H Bond Functionalization via Hydride Transfer: Synthesis of Dihydrobenzopyrans from ortho-Vinylaryl Akyl Ethers.
Kevin M. McQuaid, Jonathan Z. Long and Dalibor Sames.
Org. Lett. 2009, 11, 2972-2975. [Abstract] [Full Text-PDF]
This article was selected by the Editorial Board of Synfacts for its important insights. Synfacts 2009, 1085. [HTML] [PDF]

Fluorescent False Neurotransmitters Visualize Dopamine Release from Individual Presynaptic Terminals.
Niko G. Gubernator, Hui Zhang, Roland G. W. Staal, Eugene V. Mosharov, Daniela Pereira, Minerva Yue, Vojtech Balsanek, Paul A. Vadola, Bipasha Mukherjee, Robert H. Edwards, David Sulzer, and Dalibor Sames.
Science 2009, 324. 1441-1444. [Abstract] [Full Text-PDF]
This work has been featured in Chemical & Engineering News. [html]
This work has been also reviewed by Nature Methods [html] [pdf] and Physiology [pdf].

C-H Bonds as Ubiquitous Functionality: A General Approach to Complex Arylated Pyrazoles via Sequential Regioselective C-Arylation and N-Alkylation Enabled by SEM-Group Transposition.
Roman Goikhman, Teresa L. Jacques and Dalibor Sames.
J. Am. Chem. Soc. 2009, 131, 3042-3048. [Abstract] [Full Text-PDF]

C-H Bond Functionalization via Hydride Transfer: Lewis Acid Catalyzed Alkylation Reactions by Direct Intramolecular Coupling of sp³ C-H Bonds and Reactive Alkenyl Oxocarbenium Intermediates.
Kevin M. McQuaid and Dalibor Sames.
J. Am. Chem. Soc. 2009, 131, 402-403. [Abstract] [Full Text-PDF]
This article was selected by the Editorial Board of Synfacts for its important insights. Synfacts 2009, 407. [HTML] [PDF]
Sigma Aldrich [Link] and Organic Chemistry Portal [Link] also reviewed this article on their websites.

Imaging Induction of Cytoprotective Enzymes in Intact Human Cells: Coumberone, a Metabolic Reporter for Human AKR1C Enzymes Reveals Activation by Panaxytriol, an Active Component of Red Ginseng.
Marlin Halim, Dominic J. Yee, and Dalibor Sames.
J. Am. Chem. Soc. 2008, 130, 14123-14128. [Abstract] [Full Text-PDF]
This article was featured as a "Spotlight" in Chemical Research in Toxicology. [Abstract] [Full Text-PDF]

A Luminescent Sensor for Tyrosine Phosphorylation.
Matthew S. Tremblay, Minhee Lee, and Dalibor Sames.
Org. Lett. 2008, 10, 5-8. [Abstract] [Full Text-PDF]

Harnessing Functional Plasticity of Enzymes: A Fluorogenic Probe for Imaging 17β-HSD10 Dehydrogenase, an Enzyme Involved in Alzheimer's and Parkinson's Diseases.
Mary K. Froemming and Dalibor Sames.
J. Am. Chem. Soc. 2007, 129, 14518-14522. [Abstract] [Full Text-PDF]
This work was highlighted in the December 2007 issue of Biophotonics International (p. 12).

Ruthenium Catalyzed Decarbonylative Arylation at sp³ Carbon Centers in Pyrrolidine and Piperidine Heterocycles.
Denis V. Gribkov, Stefan J. Pastine, Michael Schnurch, and Dalibor Sames.
J. Am. Chem. Soc. 2007, 129, 11750-11755. [Abstract] [Full Text-PDF]

Transposing Molecular Fluorescent Switches into the Near-IR: Development of Luminogenic Reporter Substrates for Redox Metabolism.
Marlin Halim, Matthew S. Tremblay, Steffen Jockusch, Nicholas J. Turro, and Dalibor Sames.
J. Am. Chem. Soc. 2007, 129, 7704-7705. [Abstract] [Full Text-PDF]

Cocktails of Tb³⁺ and Eu³⁺ Complexes: A General Platform for the Design of Ratiometric Optical Probes.
Matthew S. Tremblay, Marlin Halim, and Dalibor Sames.
J. Am. Chem. Soc. 2007, 129, 7570-7577. [Abstract] [Full Text-PDF]

Two-Photon Excitation of Fluorogenic Probes for Redox Metabolism: Dramatic Enhancement of Optical Contrast Ratio by Two-Photon Excitation.
Steffen Jockusch, Qingdong Zheng, Guang S. He, Haridas E. Pudavar, Dominic J. Yee, Vojtech Balsanek, Marlin Halim, Dalibor Sames, Paras N. Prasad, and Nicholas J. Turro.
J. Phys. Chem. C 2007, 111, 8872-8877. [Abstract] [Full Text-PDF]

Phosphine-Free Palladium-Catalyzed C-H Bond Arylation of Free (N-H)-Indoles and Pyrroles.
Xiang Wang, Denis V. Gribkov, and Dalibor Sames.
J. Org. Chem. 2007, 72, 1476-1479. [Abstract] [Full Text-PDF]

sp³ C-H Bond Arylation Directed by Amidine Protecting Group: α-Arylation of Pyrrolidines and Piperidines.
Stefan J. Pastine, Denis V. Gribkov, and Dalibor Sames.
J. Am. Chem. Soc. 2006, 128, 14220-14221. [Abstract] [Full Text-PDF]

Synthesis of Luminescent Heterometallic Bis-Lanthanide Complexes via Selective, Sequential Metallation.
Matthew S. Tremblay and Dalibor Sames.
Chem. Commun. 2006, 4116-4118. [Abstract] [Full Text-PDF]

Fluorogenic Metabolic Probes for Direct Activity Readout of Redox Enzymes: Selective Measurement of Human AKR1C2 in Living Cells .
Dominic J. Yee, Vojtech Balsanek, David R. Bauman, Trevor M. Penning, and Dalibor Sames.
Proc. Natl. Acad. Sci. USA 2006, 103, 13304-13309. [Abstract] [Full Text-PDF]

Phosphorylation State-Responsive Lanthanide Peptide Conjugates: A Luminescence Switch Based on Reversible Complex Reorganization.
Matthew S. Tremblay, Qing Zhu, Angel A. Marti, Joanne Dyer, Marlin Halim, Steffen Jockusch, Nicholas J. Turro, and Dalibor Sames.
Org. Lett. 2006, 8, 2723-2726. [Abstract] [Full Text-PDF]

Catalytic C-H Arylation of SEM-Protected Azoles with Palladium Complexes of NHCs and Phosphines.
B. Barry Toure, Benjamin S. Lane, and Dalibor Sames.
Org. Lett. 2006, 8, 1979-1982. [Abstract] [Full Text-PDF]

C-H Bond Functionalization in Complex Organic Synthesis.
Kamil Godula and Dalibor Sames.
Science 2006, 312, 67-72. [Abstract] [Full Text-PDF]

Fluoromorphic Substrates for Fatty Acid Metabolism: Highly Sensitive Probes for Mammalian Medium-Chain Acyl-CoA Dehydrogenase.
Mary K. Froemming and Dalibor Sames.
Angew. Chem. Int. Ed. 2006, 45, 637-642. [Abstract] [Full Text-PDF]

Room Temperature Intramolecular Hydro-O-alkylation of Aldehydes: sp³ C-H Functionalization via a Lewis Acid Catalyzed Tandem 1,5-Hydride Transfer/Cyclization.
Stefan J. Pastine and Dalibor Sames.
Org. Lett. 2005, 7, 5429-5431. [Abstract] [Full Text-PDF]

Room Temperature Hydroalkylation of Electron-Deficient Olefins: sp³ C-H Functionalization via a Lewis Acid-Catalyzed Intramolecular Redox Event.
Stefan J. Pastine, Kevin M. McQuaid, and Dalibor Sames.
J. Am. Chem. Soc. 2005, 127, 12180-12181. [Abstract] [Full Text-PDF]
This work was highlighted in Angew. Chem. Int. Ed. 2006, 45, 1683-1684. [Full Text-PDF]

A New Fluorogenic Transformation: Development of an Optical Probe for Coenzyme Q.
Matthew S. Tremblay and Dalibor Sames.
Org. Lett. 2005, 7, 2417-2420. [Abstract] [Full Text-PDF]

Direct Palladium-Catalyzed C-2 and C-3 Arylation of Indoles: A Mechanistic Rationale for Regioselectivity.
Benjamin S. Lane, Meghann A. Brown, and Dalibor Sames.
J. Am. Chem. Soc. 2005, 127, 8050-8057. [Abstract] [Full Text-PDF]

Direct C-Arylation of Free (NH)-Indoles and Pyrroles Catalyzed by Ar-Rh(III) Complexes Assembled In Situ.
Xiang Wang, Benjamin S. Lane, and Dalibor Sames.
J. Am. Chem. Soc. 2005, 127, 4996-4997. [Abstract] [Full Text-PDF]

Two-Photon Induced Uncaging of a Reactive Intermediate. Multiphoton In Situ Detection of a Potentially Valuable Label for Biological Applications.
Joanne Dyer, Steffen Jockusch, Vojtech Balsanek, Dalibor Sames, and Nicholas J. Turro.
J. Org. Chem. 2005, 70, 2143-2147. [Abstract] [Full Text-PDF]

Design of Optical Switches as Metabolic Indicators: New Fluorogenic Probes for Monoamine Oxidases (MAO A and B).
Gong Chen, Dominic J. Yee, Niko G. Gubernator, and Dalibor Sames.
J. Am. Chem. Soc. 2005, 127, 4544-4545. [Abstract] [Full Text-PDF]

Direct C-H Bond Arylation: Selective Palladium-Catalyzed C2-Arylation of N-Substituted Indoles.
Benjamin S. Lane and Dalibor Sames.
Org. Lett. 2004, 6, 2897-2900. [Abstract] [Full Text-PDF]

Cross-Coupling of sp³ C-H Bonds and Alkenes: Catalytic Cyclization of Alkene-Amide Substrates.
Brenton DeBoef, Stefan J. Pastine, and Dalibor Sames.
J. Am. Chem. Soc. 2004, 126, 6556-6557. [Abstract] [Full Text-PDF]

New Tools for Molecular Imaging of Redox Metabolism: Development of a Fluorogenic Probe for 3r-Hydroxysteroid Dehydrogenases.
Dominic J. Yee, Vojtech Balsanek, and Dalibor Sames.
J. Am. Chem. Soc. 2004, 126, 2282-2283. [Abstract] [Full Text-PDF]

Ru(III)-Catalyzed Cyclization of Arene-Alkene Substrates via Intramolecular Electrophilic Hydroarylation.
So Won Youn, Stefan J. Pastine, and Dalibor Sames.
Org. Lett. 2004, 6, 581-584. [Abstract] [Full Text-PDF]

Concise Synthesis of the Chemopreventitive Agent (±)-Deguelin via a Key 6-Endo Hydroarylation.
Stefan J. Pastine and Dalibor Sames.
Org. Lett. 2003, 5, 4053-4055. [Abstract] [Full Text-PDF]

Reactivity of Functional Groups on the Protein Surface: Development of Epoxide Probes for Protein Labeling.
Gong Chen, Alexander Heim, Doris Riether, Dominic Yee, Yelena Milgrom, Mary Ann Gawinowicz, and Dalibor Sames.
J. Am. Chem. Soc. 2003, 125, 8130-8133. [Abstract] [Full Text-PDF]

Pt(IV)-Catalyzed Cyclization of Arene-Alkyne Substrates via C-H Bond Functionalization.
Stefan J. Pastine, So Won Youn, and Dalibor Sames.
Tetrahedron 2003, 59, 8859-8868. [Abstract] [Full Text-PDF]
This article was one of the most cited papers in Tetrahedron, 2003-2006.

Pt(IV)-Catalyzed Cyclization of Arene-Alkyne Substrates via Intramolecular Electrophilic Hydroarylation.
Stefan J. Pastine, So Won Youn, and Dalibor Sames.
Org. Lett. 2003, 5, 1055-1058. [Abstract] [Full Text-PDF]

C-C Bond Formation via C-H Bond Activation: Synthesis of the Core of Teleocidin B4.
Brian D. Dangel, Kamil Godula, So Won Youn, Bengü Sezen, and Dalibor Sames.
J. Am. Chem. Soc. 2002, 124, 11856-11857. [Abstract] [Full Text-PDF]
This work was highlighted in Chemtracts-Organic Chemistry 2003,16, 249-253. [Full Text-PDF]

Total Synthesis of (-)-Rhazinilam: Asymmetric C-H Bond Activation via the Use of a Chiral Auxiliary.
James A. Johnson, Ning Li, and Dalibor Sames.
J. Am. Chem. Soc. 2002, 124, 6900-6903. [Abstract] [Full Text-PDF]

Selective Functionalization of Amino Acids in Water: A Synthetic Method via Catalytic C-H Bond Activation.
Brian D. Dangel, James A. Johnson, and Dalibor Sames.
J. Am. Chem. Soc. 2001, 123, 8149-8150. [Abstract] [Full Text-PDF]
This work was highlighted in Chem. & Eng. News 2001, 79, 33. [Full Text-HTML]

New Fluorogenic Probes for Oxygen and Carbene Transfer: A Sensitive Assay for Single Bead-Supported Catalysts.
Rayane Moreira, Miroslav Havranek, and Dalibor Sames.
J. Am. Chem. Soc. 2001, 123, 3927-3931. [Abstract] [Full Text-PDF]

C-H Bond Activation of Hydrocarbon Segments in Complex Organic Molecules: Total Synthesis of the Antimitotic Rhazinilam.
James A. Johnson and Dalibor Sames.
J. Am. Chem. Soc. 2000, 122, 6321-6322. [Abstract] [Full Text-PDF]
This work was highlighted in Chem. & Eng. News 2000,78, 12. [Full Text-HTML]

Combinatorial Approach to the Development of Fluorescent Sensors for Nanomolar Aqueous Copper.
Arun Singh, Qingwei Yao, Ling Tong, W. Clark Still and Dalibor Sames.
Tetrahedron Lett. 2000, 41, 9601-9605. [Abstract] [Full Text-PDF]

Highly Regioselective Oxygenation of C-H Bonds: Diamidomanganese Constructs with Attached Substrates as Catalyst Models.
Rayane F. Moreira, Paul M. Wehn, Dalibor Sames.
Angew. Chem. Int. Ed. 2000, 39, 1618-1621. [Abstract] [Full Text-PDF]

Evolution and Study of Polymer-Supported Metal Catalysts for Oxygen Atom Transfer: Oxidation of Alkanes and Alkenes by Diamide Manganese Complexes.
Miroslav Havranek, Arun Singh, and Dalibor Sames.
J. Am. Chem. Soc. 1999, 121, 8965-8966. [Abstract] [Full Text-PDF]