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Dr. John Glendinning

Title Professor
Affiliation/Department Department of Biological Sciences, Barnard College
Telephone (212) 854-4749
Professional degree Ph.D., University of Florida, 1989
Research Keywords Sensory Physiology; Animal Behavior; Plant-Herbivore Interactions
Research Description I am interested in the chemosensory mechanisms that control the feeding behavior of insects and mammals. Most of my recent projects have focused on how herbivorous aimals cope with the unpalatable and potentially toxic compounds present in many plant tissues. I have been examining the contribution of taste and viscerosensory response mechanisms to this coping process. I study these phenomena wtih a combination of behavioral, electrophysiological and molecular appoaches.
Representative Publications

Spector AC, Glendinning JI (2009) Linking peripheral taste processes to behavior. Current Opinion in Neurobiology 19: 370-377

Glendinning JI, Foley C , Loncar I , Rai M (2009) Induced preference for host plant chemicals in the tobacco hornworm: contribution of olfaction and taste. Journal of Comparative Physiology A 195: 591-601

Youngentob SL, Glendinning JI (2009) Fetal ethanol exposure increases ethanol intake by making it smell and taste better. Proceedings of the National Academy of Sciences USA 106(13): 5359-64

Zukerman S, Glendinning JI, Margolskee RF, Sclafani A (2009) T1R3 taste receptor is critical for sucrose but not Polycose taste. American Journal of Physiology 296: R866–R876

Glendinning JI, Feld N , Goodman L , Bayor R (2008) Orosensory attributes of oil influence daily intake of low, but not high concentrations of oil in mice. Physiology & Behavior 95: 476-483.

Glendinning JI, Yiin Y-M, Ackroff K, Sclafani A (2008) Intragastric infusion of denatonium conditions flavor aversions and delays gastric emptying in rodents. Physiology and Behavior 93: 757-765.

Glendinning JI (2008) Insect gustatory systems. In: Basbaum AI, Kaneko A, Shepherd GM, Westheimer G (eds) The Senses: A Comprehensive Reference, Volume 4, Olfaction and taste, Firestein S, Beauchamp GK. San Diego: Academic Press. p 75-95.

Glendinning JI, Jerud A , Weinberg A (2007) The hungry caterpillar: an analysis of how carbohydrates stimulate feeding in Manduca sexta . The Journal of Experimental Biology 210: 3054-3067

Glendinning JI (2007) How do predators cope with chemically defended foods? The Biological Bulletin 213: 252-266

Sclafani A, Zukerman S, Glendinning JI, Margolskee RF (2007) Fat and carbohydrate preferences in mice: the contribution of a-gustducin and Trpm5 taste signaling proteins. American Journal of Physiology 293: R1504–R1513.

Inoue M, Glendinning JI, Theodorides ML , Harkness S , Li X, Bosak N, Beauchamp GK, Bachmanov AA (2007) Polymorphisms in the Tas1r3 taste receptor gene alter taste responses to sweeteners: evidence from 129.B6- Tas1r3 congenic mice . Physiological Genomics 32(1): 82-94

Damak S, Rong M, Yasumatsu K, Kokrashvilli Z, Pérex CA, Shigemura N, Yoshida R, Mosinger B, Glendinning JI, Ninomiya Y, Margolskee RF (2006) Trpm5 null mice respond to bitter, sweet and umami compounds. Chemical Senses 31: 253-264.

Glendinning JI, Davis A , Rai M (2006) Temporal coding mediates discrimination of “bitter” taste stimuli by an insect (2006) The Journal of Neuroscience 26(35): 8900-8908

Glendinning JI, Bloom LD , Onishi M , Zheng KH , Damak S, Margolskee RF, Spector AC (2005) Contribution of a-gustducin to taste-guided licking responses of mice (2005) Chemical Senses 30(4): 299-316

Glendinning JI, Chyou S , Lin I, Onishi M , Patel P , Young MJ , Zheng KH (2005) Initial licking responses of mice to sweeteners: effects of Tas1r3 polymorphisms. Chemical Senses 30(7): 601-614

Sclafani A, Glendinning JI (2005) Sugar and fat conditioned flavor preferences in C57BL/6 and 129 mice: oral and post-oral interactions. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology 289(3): R712-720

Sclafani A, Glendinning JI (2003) Flavor preferences conditioned in C57BL/6 mice by intragastric carbohydrate self-infusion. Physiology and Behavior 79: 783–788

Glendinning JI, Davis A, Ramaswamy S (2002) Contribution of different taste cells and signaling pathways to the discrimination of ‘bitter' taste stimuli by an insect. The Journal of Neuroscience 22(16): 7281-7287