Columbia University > Department of Biochemistry and Molecular Biophysics > The Frank Lab

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Refereed original manuscripts

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Title Villa, E., Sengupta, J., Trabuco, L.G., LeBarron, J., Baxter, W.T., Shaikh, T.R., Grassucci, R.A., Nissen, P., Ehrenberg, M., Schulten, K., et al. (2009). Ribosome-induced changes in elongation factor Tu conformation control GTP hydrolysis. Proc Natl Acad Sci U S A 106, 1063-1068. PMID: 19122150; PMCid: PMC2613361. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19122150

Taylor, D., Devkota, B., Huang, A.D., Topf, M., Narayanan, E., Sali, A., Harvey, S.C., and Frank, J. (2009). Comprehensive molecular structure of the eukaryotic ribosome. Structure, in press PMID: PMCid:

Sorci, M., Grassucci, R.A., Hahn, I., Frank, J., and Belfort, G. (2009). Time-dependent insulin oligomer reaction pathway prior to fibril formation: cooling and seeding. Proteins 77, 62-73. PMID: 19408310; 130867; PMCid: PMC2737737. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19408310

Baxter, W.T., Grassucci, R.A., Gao, H., and Frank, J. (2009). Determination of signal-to-noise ratios and spectral SNRs in cryo-EM low-dose imaging of molecules. J Struct Biol. PMID: 19269332; 112289 PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19269332

Trabuco, L.G., Villa, E., Mitra, K., Frank, J., and Schulten, K. (2008). Flexible fitting of atomic structures into electron microscopy maps using molecular dynamics. Structure 16, 673-683. PMID: 18462672; PMCid: PMC2430731. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18462672

Shaikh, T.R., Trujillo, R., LeBarron, J.S., Baxter, W.T., and Frank, J. (2008). Particle-verification for single-particle, reference-based reconstruction using multivariate data analysis and classification. J Struct Biol 164, 41-48. PMID: 18619547; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18619547

Sengupta, J., Nilsson, J., Gursky, R., Kjeldgaard, M., Nissen, P., and Frank, J. (2008). Visualization of the eEF2-80S ribosome transition-state complex by cryo-electron microscopy. J Mol Biol 382, 179-187. PMID: 18644383; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18644383

Renken, C., Hsieh, C.E., Marko, M., Rath, B., Leith, A., Wagenknecht, T., Frank, J., and Mannella, C.A. (2008). Structure of frozen-hydrated triad junctions: A case study in motif searching inside tomograms. J Struct Biol. PMID: 19028586; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19028586

Li, W., Agirrezabala, X., Lei, J., Bouakaz, L., Brunelle, J.L., Ortiz-Meoz, R.F., Green, R., Sanyal, S., Ehrenberg, M., and Frank, J. (2008). Recognition of aminoacyl-tRNA: a common molecular mechanism revealed by cryo-EM. EMBO J 27, 3322-3331. PMID: 19020518; PMCid: PMC2586802. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19020518

LeBarron, J., Grassucci, R.A., Shaikh, T.R., Baxter, W.T., Sengupta, J., and Frank, J. (2008). Exploration of parameters in cryo-EM leading to an improved density map of the E. coli ribosome. J Struct Biol 164, 24-32. PMID: 18606549; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18606549

Frank, J. (2008). Under the Rug, or a Plea for the Lighter Touch. J Struct Biol 163, 270. PMID: 19255612; NIHMS72627; PMCid: PMC2577220. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19255612

Agirrezabala, X., Lei, J., Brunelle, J.L., Ortiz-Meoz, R.F., Green, R., and Frank, J. (2008). Visualization of the hybrid state of tRNA binding promoted by spontaneous ratcheting of the ribosome. Mol Cell 32, 190-197. PMID: 18951087; PMCid: PMC2614368. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18951087

Yang, C., Penczek, P.A., Leith, A., Asturias, F.J., Ng, E.G., Glaeser, R.M., and Frank, J. (2007). The parallelization of SPIDER on distributed-memory computers using MPI. J Struct Biol 157, 240-249. PMID: 16859923; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16859923

Taylor, D.J., Nilsson, J., Merrill, A.R., Andersen, G.R., Nissen, P., and Frank, J. (2007). Structures of modified eEF2 80S ribosome complexes reveal the role of GTP hydrolysis in translocation. EMBO J 26, 2421-2431. PMID: 17446867; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17446867

Scheres, S.H., Gao, H., Valle, M., Herman, G.T., Eggermont, P.P., Frank, J., and Carazo, J.M. (2007). Disentangling conformational states of macromolecules in 3D-EM through likelihood optimization. Nat Methods 4, 27-29. PMID: 17179934; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17179934

Nilsson, J., Sengupta, J., Gursky, R., Nissen, P., and Frank, J. (2007). Comparison of fungal 80 S ribosomes by cryo-EM reveals diversity in structure and conformation of rRNA expansion segments. J Mol Biol 369, 429-438. PMID: 17434183; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17434183

Marko, M., Hsieh, C., Schalek, R., Frank, J., and Mannella, C. (2007). Focused-ion-beam thinning of frozen-hydrated biological specimens for cryo-electron microscopy. Nat Methods 4, 215-217. PMID: 17277781; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17277781

Li, W., and Frank, J. (2007). Transfer RNA in the hybrid P/E state: correlating molecular dynamics simulations with cryo-EM data. Proc Natl Acad Sci U S A 104, 16540-16545. PMID: 17925437; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17925437

LeBarron, J., Mitra, K., and Frank, J. (2007). Displaying 3D data on RNA secondary structures: coloRNA. J Struct Biol 157, 262-270. PMID: 17070699; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17070699

Gillet, R., Kaur, S., Li, W., Hallier, M., Felden, B., and Frank, J. (2007). Scaffolding as an organizing principle in trans-translation. The roles of small protein B and ribosomal protein S1. J Biol Chem 282, 6356-6363. PMID: 17179154; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17179154

Gao, N., Zavialov, A.V., Ehrenberg, M., and Frank, J. (2007). Specific interaction between EF-G and RRF and its implication for GTP-dependent ribosome splitting into subunits. J Mol Biol 374, 1345-1358. PMID: 17996252; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17996252

Gao, H., Zhou, Z., Rawat, U., Huang, C., Bouakaz, L., Wang, C., Cheng, Z., Liu, Y., Zavialov, A., Gursky, R., et al. (2007). RF3 induces ribosomal conformational changes responsible for dissociation of class I release factors. Cell 129, 929-941. PMID: 17540173; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17540173

Fu, J., Gao, H., and Frank, J. (2007). Unsupervised classification of single particles by cluster tracking in multi-dimensional space. J Struct Biol 157, 226-239. PMID: 16931050; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16931050

Frank, J., Gao, H., Sengupta, J., Gao, N., and Taylor, D.J. (2007). The process of mRNA-tRNA translocation. Proc Natl Acad Sci U S A 104, 19671-19678. PMID: 18003906; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18003906

Baxter, W.T., Leith, A., and Frank, J. (2007). SPIRE: the SPIDER reconstruction engine. J Struct Biol 157, 56-63. PMID: 17055743; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17055743

Slagter-Jager, J.G., Allen, G.S., Smith, D., Hahn, I.A., Frank, J., and Belfort, M. (2006). Visualization of a group II intron in the 23S rRNA of a stable ribosome. Proc Natl Acad Sci U S A 103, 9838-9843. PMID: 16785426; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16785426

Rawat, U., Gao, H., Zavialov, A., Gursky, R., Ehrenberg, M., and Frank, J. (2006). Interactions of the release factor RF1 with the ribosome as revealed by cryo-EM. J Mol Biol 357, 1144-1153. PMID: 16476444; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16476444

Penczek, P.A., Yang, C., Frank, J., and Spahn, C.M. (2006). Estimation of variance in single-particle reconstruction using the bootstrap technique. J Struct Biol 154, 168-183. PMID: 16510296; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16510296

Penczek, P.A., Frank, J., and Spahn, C.M. (2006). A method of focused classification, based on the bootstrap 3D variance analysis, and its application to EF-G-dependent translocation. J Struct Biol 154, 184-194. PMID: 16520062; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16520062

Mitra, K., Schaffitzel, C., Fabiola, F., Chapman, M.S., Ban, N., and Frank, J. (2006). Elongation arrest by SecM via a cascade of ribosomal RNA rearrangements. Mol Cell 22, 533-543. PMID: 16713583; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16713583

Mitra, K., Frank, J., and Driessen, A. (2006). Co- and post-translational translocation through the protein-conducting channel: analogous mechanisms at work? Nat Struct Mol Biol 13, 957-964. PMID: 17082791; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17082791

Mitra, K., and Frank, J. (2006). A model for co-translational translocation: ribosome-regulated nascent polypeptide translocation at the protein-conducting channel. FEBS Lett 580, 3353-3360. PMID: 16714018; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16714018

Marko, M., Hsieh, C., Moberlychan, W., Mannella, C.A., and Frank, J. (2006). Focused ion beam milling of vitreous water: prospects for an alternative to cryo-ultramicrotomy of frozen-hydrated biological samples. J Microsc 222, 42-47. PMID: 16734713; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16734713

Li, W., Sengupta, J., Rath, B.K., and Frank, J. (2006). Functional conformations of the L11-ribosomal RNA complex revealed by correlative analysis of cryo-EM and molecular dynamics simulations. RNA 12, 1240-1253. PMID: 16682558; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16682558

Kaur, S., Gillet, R., Li, W., Gursky, R., and Frank, J. (2006). Cryo-EM visualization of transfer messenger RNA with two SmpBs in a stalled ribosome. Proc Natl Acad Sci U S A 103, 16484-16489. PMID: 17056712; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17056712

Hsieh, C.E., Leith, A., Mannella, C.A., Frank, J., and Marko, M. (2006). Towards high-resolution three-dimensional imaging of native mammalian tissue: electron tomography of frozen-hydrated rat liver sections. J Struct Biol 153, 1-13. PMID: 16343943; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16343943

Berman, H.M., Burley, S.K., Chiu, W., Sali, A., Adzhubei, A., Bourne, P.E., Bryant, S.H., Dunbrack, R.L., Jr., Fidelis, K., Frank, J., et al. (2006). Outcome of a workshop on archiving structural models of biological macromolecules. Structure 14, 1211-1217. PMID: 16955948; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16955948

Mitra, K., Schaffitzel, C., Shaikh, T., Tama, F., Jenni, S., Brooks, C.L., 3rd, Ban, N., and Frank, J. (2005). Structure of the E. coli protein-conducting channel bound to a translating ribosome. Nature 438, 318-324. PMID: 16292303; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16292303

Lei, J., and Frank, J. (2005). Automated acquisition of cryo-electron micrographs for single particle reconstruction on an FEI Tecnai electron microscope. J Struct Biol 150, 69-80. PMID: 15797731; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15797731

Halic, M., Becker, T., Frank, J., Spahn, C.M., and Beckmann, R. (2005). Localization and dynamic behavior of ribosomal protein L30e. Nat Struct Mol Biol 12, 467-468. PMID: 15864315; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15864315

Gao, N., Zavialov, A.V., Li, W., Sengupta, J., Valle, M., Gursky, R.P., Ehrenberg, M., and Frank, J. (2005). Mechanism for the disassembly of the posttermination complex inferred from cryo-EM studies. Mol Cell 18, 663-674. PMID: 15949441; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15949441

Gao, H., and Frank, J. (2005). Molding atomic structures into intermediate-resolution cryo-EM density maps of ribosomal complexes using real-space refinement. Structure 13, 401-406. PMID: 15766541; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15766541

Gao, H., Ayub, M.J., Levin, M.J., and Frank, J. (2005). The structure of the 80S ribosome from Trypanosoma cruzi reveals unique rRNA components. Proc Natl Acad Sci U S A 102, 10206-10211. PMID: 16014419; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16014419

Datta, P.P., Sharma, M.R., Qi, L., Frank, J., and Agrawal, R.K. (2005). Interaction of the G' domain of elongation factor G and the C-terminal domain of ribosomal protein L7/L12 during translocation as revealed by cryo-EM. Mol Cell 20, 723-731. PMID: 16337596; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16337596

Allen, G.S., Zavialov, A., Gursky, R., Ehrenberg, M., and Frank, J. (2005). The cryo-EM structure of a translation initiation complex from Escherichia coli. Cell 121, 703-712. PMID: 15935757; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15935757

Adiga, U., Baxter, W.T., Hall, R.J., Rockel, B., Rath, B.K., Frank, J., and Glaeser, R. (2005). Particle picking by segmentation: a comparative study with SPIDER-based manual particle picking. J Struct Biol 152, 211-220. PMID: 16330229; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16330229

Spahn, C.M., Jan, E., Mulder, A., Grassucci, R.A., Sarnow, P., and Frank, J. (2004). Cryo-EM visualization of a viral internal ribosome entry site bound to human ribosomes: the IRES functions as an RNA-based translation factor. Cell 118, 465-475. PMID: 15315759; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15315759

Spahn, C.M., Gomez-Lorenzo, M.G., Grassucci, R.A., Jorgensen, R., Andersen, G.R., Beckmann, R., Penczek, P.A., Ballesta, J.P., and Frank, J. (2004). Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation. EMBO J 23, 1008-1019. PMID: 14976550; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=14976550

Sengupta, J., Nilsson, J., Gursky, R., Spahn, C.M., Nissen, P., and Frank, J. (2004). Identification of the versatile scaffold protein RACK1 on the eukaryotic ribosome by cryo-EM. Nat Struct Mol Biol 11, 957-962. PMID: 15334071; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15334071

Rath, B.K., and Frank, J. (2004). Fast automatic particle picking from cryo-electron micrographs using a locally normalized cross-correlation function: a case study. J Struct Biol 145, 84-90. PMID: 15065676; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15065676

Nilsson, J., Sengupta, J., Frank, J., and Nissen, P. (2004). Regulation of eukaryotic translation by the RACK1 protein: a platform for signalling molecules on the ribosome. EMBO Rep 5, 1137-1141. PMID: 15577927; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15577927

Halic, M., Becker, T., Pool, M.R., Spahn, C.M., Grassucci, R.A., Frank, J., and Beckmann, R. (2004). Structure of the signal recognition particle interacting with the elongation-arrested ribosome. Nature 427, 808-814. PMID: 14985753; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=14985753

Gao, H., Valle, M., Ehrenberg, M., and Frank, J. (2004). Dynamics of EF-G interaction with the ribosome explored by classification of a heterogeneous cryo-EM dataset. J Struct Biol 147, 283-290. PMID: 15450297; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15450297

Frank, J., and Schlichting, I. (2004). Time-resolved imaging of macromolecular processes and interactions. J Struct Biol 147, 209-210. PMID: 15450290; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15450290

Agrawal, R.K., Sharma, M.R., Kiel, M.C., Hirokawa, G., Booth, T.M., Spahn, C.M., Grassucci, R.A., Kaji, A., and Frank, J. (2004). Visualization of ribosome-recycling factor on the Escherichia coli 70S ribosome: functional implications. Proc Natl Acad Sci U S A 101, 8900-8905. PMID: 15178758; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15178758

Yarus, M., Valle, M., and Frank, J. (2003). A twisted tRNA intermediate sets the threshold for decoding. RNA 9, 384-385. PMID: 12649490; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12649490

Valle, M., Zavialov, A., Sengupta, J., Rawat, U., Ehrenberg, M., and Frank, J. (2003). Locking and unlocking of ribosomal motions. Cell 114, 123-134. PMID: 12859903; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12859903

Valle, M., Zavialov, A., Li, W., Stagg, S.M., Sengupta, J., Nielsen, R.C., Nissen, P., Harvey, S.C., Ehrenberg, M., and Frank, J. (2003). Incorporation of aminoacyl-tRNA into the ribosome as seen by cryo-electron microscopy. Nat Struct Biol 10, 899-906. PMID: 14566331; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=14566331

Valle, M., Gillet, R., Kaur, S., Henne, A., Ramakrishnan, V., and Frank, J. (2003). Visualizing tmRNA entry into a stalled ribosome. Science 300, 127-130. PMID: 12677067; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12677067

Tama, F., Valle, M., Frank, J., and Brooks, C.L., 3rd (2003). Dynamic reorganization of the functionally active ribosome explored by normal mode analysis and cryo-electron microscopy. Proc Natl Acad Sci U S A 100, 9319-9323. PMID: 12878726; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12878726

Shaikh, T.R., Hegerl, R., and Frank, J. (2003). An approach to examining model dependence in EM reconstructions using cross-validation. J Struct Biol 142, 301-310. PMID: 12713958; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12713958

Rawat, U.B., Zavialov, A.V., Sengupta, J., Valle, M., Grassucci, R.A., Linde, J., Vestergaard, B., Ehrenberg, M., and Frank, J. (2003). A cryo-electron microscopic study of ribosome-bound termination factor RF2. Nature 421, 87-90. PMID: 12511960; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12511960

Rath, B.K., Hegerl, R., Leith, A., Shaikh, T.R., Wagenknecht, T., and Frank, J. (2003). Fast 3D motif search of EM density maps using a locally normalized cross-correlation function. J Struct Biol 144, 95-103. PMID: 14643212; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=14643212

Moccia, R., Chen, D., Lyles, V., Kapuya, E., E, Y., Kalachikov, S., Spahn, C.M., Frank, J., Kandel, E.R., Barad, M., et al. (2003). An unbiased cDNA library prepared from isolated Aplysia sensory neuron processes is enriched for cytoskeletal and translational mRNAs. J Neurosci 23, 9409-9417. PMID: 14561869; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=14561869

Gomez-Lorenzo, M.G., Valle, M., Frank, J., Gruss, C., Sorzano, C.O., Chen, X.S., Donate, L.E., and Carazo, J.M. (2003). Large T antigen on the simian virus 40 origin of replication: a 3D snapshot prior to DNA replication. EMBO J 22, 6205-6213. PMID: 14633980; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=14633980

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Valle, M., Sengupta, J., Swami, N.K., Grassucci, R.A., Burkhardt, N., Nierhaus, K.H., Agrawal, R.K., and Frank, J. (2002). Cryo-EM reveals an active role for aminoacyl-tRNA in the accommodation process. EMBO J 21, 3557-3567. PMID: 12093756; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12093756

Stagg, S.M., Valle, M., Agrawal, R.K., Frank, J., and Harvey, S.C. (2002). Problems with the transorientation hypothesis. RNA 8, 1093-1094. PMID: 12358427; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12358427

Hsieh, C.E., Marko, M., Frank, J., and Mannella, C.A. (2002). Electron tomographic analysis of frozen-hydrated tissue sections. J Struct Biol 138, 63-73. PMID: 12160702; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12160702

Gao, H., Spahn, C.M., Grassucci, R.A., and Frank, J. (2002). An assay for local quality in cryo-electron micrographs of single particles. Ultramicroscopy 93, 169-178. PMID: 12425594; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12425594

Spahn, C.M., Kieft, J.S., Grassucci, R.A., Penczek, P.A., Zhou, K., Doudna, J.A., and Frank, J. (2001). Hepatitis C virus IRES RNA-induced changes in the conformation of the 40S ribosomal subunit. Science 291, 1959-1962. PMID: 11239155; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11239155

Spahn, C.M., Blaha, G., Agrawal, R.K., Penczek, P., Grassucci, R.A., Trieber, C.A., Connell, S.R., Taylor, D.E., Nierhaus, K.H., and Frank, J. (2001). Localization of the ribosomal protection protein Tet(O) on the ribosome and the mechanism of tetracycline resistance. Mol Cell 7, 1037-1045. PMID: 11389850; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11389850

Spahn, C.M., Beckmann, R., Eswar, N., Penczek, P.A., Sali, A., Blobel, G., and Frank, J. (2001). Structure of the 80S ribosome from Saccharomyces cerevisiae--tRNA-ribosome and subunit-subunit interactions. Cell 107, 373-386. PMID: 11701127; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11701127

Sengupta, J., Agrawal, R.K., and Frank, J. (2001). Visualization of protein S1 within the 30S ribosomal subunit and its interaction with messenger RNA. Proc Natl Acad Sci U S A 98, 11991-11996. PMID: 11593008; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11593008

McEwen, B.F., and Frank, J. (2001). Electron tomographic and other approaches for imaging molecular machines. Curr Opin Neurobiol 11, 594-600. PMID: 11595494; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11595494

Gabashvili, I.S., Gregory, S.T., Valle, M., Grassucci, R., Worbs, M., Wahl, M.C., Dahlberg, A.E., and Frank, J. (2001). The polypeptide tunnel system in the ribosome and its gating in erythromycin resistance mutants of L4 and L22. Mol Cell 8, 181-188. PMID: 11511371; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11511371

Beckmann, R., Spahn, C.M., Eswar, N., Helmers, J., Penczek, P.A., Sali, A., Frank, J., and Blobel, G. (2001). Architecture of the protein-conducting channel associated with the translating 80S ribosome. Cell 107, 361-372. PMID: 11701126; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11701126

Agrawal, R.K., Linde, J., Sengupta, J., Nierhaus, K.H., and Frank, J. (2001). Localization of L11 protein on the ribosome and elucidation of its involvement in EF-G-dependent translocation. J Mol Biol 311, 777-787. PMID: 11518530; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11518530

Wriggers, W., Agrawal, R.K., Drew, D.L., McCammon, A., and Frank, J. (2000). Domain motions of EF-G bound to the 70S ribosome: insights from a hand-shaking between multi-resolution structures. Biophys J 79, 1670-1678. PMID: 10969026; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10969026

VanLoock, M.S., Agrawal, R.K., Gabashvili, I.S., Qi, L., Frank, J., and Harvey, S.C. (2000). Movement of the decoding region of the 16 S ribosomal RNA accompanies tRNA translocation. J Mol Biol 304, 507-515. PMID: 11099376; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11099376

Spahn, C.M., Penczek, P.A., Leith, A., and Frank, J. (2000). A method for differentiating proteins from nucleic acids in intermediate-resolution density maps: cryo-electron microscopy defines the quaternary structure of the Escherichia coli 70S ribosome. Structure 8, 937-948. PMID: 10986461; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10986461

Gomez-Lorenzo, M.G., Spahn, C.M., Agrawal, R.K., Grassucci, R.A., Penczek, P., Chakraburtty, K., Ballesta, J.P., Lavandera, J.L., Garcia-Bustos, J.F., and Frank, J. (2000). Three-dimensional cryo-electron microscopy localization of EF2 in the Saccharomyces cerevisiae 80S ribosome at 17.5 Å resolution. EMBO J 19, 2710-2718. PMID: 10835368; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10835368

Gabashvili, I.S., Agrawal, R.K., Spahn, C.M., Grassucci, R.A., Svergun, D.I., Frank, J., and Penczek, P. (2000). Solution structure of the E. coli 70S ribosome at 11.5 Å resolution. Cell 100, 537-549. PMID: 10721991; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10721991

Frank, J., and Agrawal, R.K. (2000). A ratchet-like inter-subunit reorganization of the ribosome during translocation. Nature 406, 318-322. PMID: 10917535; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10917535

Agrawal, R.K., Spahn, C.M., Penczek, P., Grassucci, R.A., Nierhaus, K.H., and Frank, J. (2000). Visualization of tRNA movements on the Escherichia coli 70S ribosome during the elongation cycle. J Cell Biol 150, 447-460. PMID: 10931859; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10931859

Spahn, C.M., Grassucci, R.A., Penczek, P., and Frank, J. (1999). Direct three-dimensional localization and positive identification of RNA helices within the ribosome by means of genetic tagging and cryo-electron microscopy. Structure 7, 1567-1573. PMID: 10647187; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10647187

McCutcheon, J.P., Agrawal, R.K., Philips, S.M., Grassucci, R.A., Gerchman, S.E., Clemons, W.M., Jr., Ramakrishnan, V., and Frank, J. (1999). Location of translational initiation factor IF3 on the small ribosomal subunit. Proc Natl Acad Sci U S A 96, 4301-4306. PMID: 10200257; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10200257

Gabashvili, I.S., Agrawal, R.K., Grassucci, R., Squires, C.L., Dahlberg, A.E., and Frank, J. (1999). Major rearrangements in the 70S ribosomal 3D structure caused by a conformational switch in 16S ribosomal RNA. EMBO J 18, 6501-6507. PMID: 10562562; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10562562

Gabashvili, I.S., Agrawal, R.K., Grassucci, R., and Frank, J. (1999). Structure and structural variations of the Escherichia coli 30 S ribosomal subunit as revealed by three-dimensional cryo-electron microscopy. J Mol Biol 286, 1285-1291. PMID: 10064696; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10064696

Frank, J., Heagle, A.B., and Agrawal, R.K. (1999). Animation of the dynamical events of the elongation cycle based on cryoelectron microscopy of functional complexes of the ribosome. J Struct Biol 128, 15-18. PMID: 10600553; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10600553

Agrawal, R.K., Penczek, P., Grassucci, R.A., Burkhardt, N., Nierhaus, K.H., and Frank, J. (1999). Effect of buffer conditions on the position of tRNA on the 70 S ribosome as visualized by cryoelectron microscopy. J Biol Chem 274, 8723-8729. PMID: 10085112; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10085112

Agrawal, R.K., Heagle, A.B., Penczek, P., Grassucci, R.A., and Frank, J. (1999). EF-G-dependent GTP hydrolysis induces translocation accompanied by large conformational changes in the 70S ribosome. Nat Struct Biol 6, 643-647. PMID: 10404220; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10404220

Verschoor, A., Warner, J.R., Srivastava, S., Grassucci, R.A., and Frank, J. (1998). Three-dimensional structure of the yeast ribosome. Nucleic Acids Res 26, 655-661. PMID: 9421530; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9421530

Samso, M., Radermacher, M., Frank, J., and Koonce, M.P. (1998). Structural characterization of a dynein motor domain. J Mol Biol 276, 927-937. PMID: 9566197; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9566197

Malhotra, A., Penczek, P., Agrawal, R.K., Gabashvili, I.S., Grassucci, R.A., Junemann, R., Burkhardt, N., Nierhaus, K.H., and Frank, J. (1998). Escherichia coli 70 S ribosome at 15 Å resolution by cryo-electron microscopy: localization of fMet-tRNAfMet and fitting of L1 protein. J Mol Biol 280, 103-116. PMID: 9653034; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9653034

Frank, J., and Agrawal, R.K. (1998). The movement of tRNA through the ribosome. Biophys J 74, 589-594. PMID: 9449359; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9449359

Ban, N., Freeborn, B., Nissen, P., Penczek, P., Grassucci, R.A., Sweet, R., Frank, J., Moore, P.B., and Steitz, T.A. (1998). A 9 Å resolution X-ray crystallographic map of the large ribosomal subunit. Cell 93, 1105-1115. PMID: 9657144; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9657144

Agrawal, R.K., Penczek, P., Grassucci, R.A., and Frank, J. (1998). Visualization of elongation factor G on the Escherichia coli 70S ribosome: the mechanism of translocation. Proc Natl Acad Sci U S A 95, 6134-6138. PMID: 9600930; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9600930

Zhu, J., Penczek, P.A., Schroder, R., and Frank, J. (1997). Three-dimensional reconstruction with contrast transfer function correction from energy-filtered cryoelectron micrographs: procedure and application to the 70S Escherichia coli ribosome. J Struct Biol 118, 197-219. PMID: 9169230; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9169230

Wadzack, J., Burkhardt, N., Junemann, R., Diedrich, G., Nierhaus, K.H., Frank, J., Penczek, P., Meerwinck, W., Schmitt, M., Willumeit, R., et al. (1997). Direct localization of the tRNAs within the elongating ribosome by means of neutron scattering (proton-spin contrast-variation). J Mol Biol 266, 343-356. PMID: 9047368; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9047368

Rath, B.K., Marko, M., Radermacher, M., and Frank, J. (1997). Low-dose automated electron tomography: a recent implementation. J Struct Biol 120, 210-218. PMID: 9441926; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9441926

Li, Y., Leith, A., and Frank, J. (1997). Tinkerbell--a tool for interactive segmentation of 3D data. J Struct Biol 120, 266-275. PMID: 9441932; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9441932

Beckmann, R., Bubeck, D., Grassucci, R., Penczek, P., Verschoor, A., Blobel, G., and Frank, J. (1997). Alignment of conduits for the nascent polypeptide chain in the ribosome-Sec61 complex. Science 278, 2123-2126. PMID: 9405348; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9405348

Verschoor, A., Srivastava, S., Grassucci, R., and Frank, J. (1996). Native 3D structure of eukaryotic 80s ribosome: morphological homology with E. coli 70S ribosome. J Cell Biol 133, 495-505. PMID: 8636226; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8636226

Penczek, P.A., Zhu, J., and Frank, J. (1996). A common-lines based method for determining orientations for N > 3 particle projections simultaneously. Ultramicroscopy 63, 205-218. PMID: 8921628; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8921628

Marabini, R., Vaquerizo, C., Fernandez, J.J., Carazo, J.M., Engel, A., and Frank, J. (1996). Proposal for a new distributed database of macromolecular and subcellular structures from different areas of microscopy. J Struct Biol 116, 161-165. PMID: 8742739; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8742739

Lata, K.R., Agrawal, R.K., Penczek, P., Grassucci, R., Zhu, J., and Frank, J. (1996). Three-dimensional reconstruction of the Escherichia coli 30 S ribosomal subunit in ice. J Mol Biol 262, 43-52. PMID: 8809178; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8809178

Frank, J., Radermacher, M., Penczek, P., Zhu, J., Li, Y., Ladjadj, M., and Leith, A. (1996). SPIDER and WEB: processing and visualization of images in 3D electron microscopy and related fields. J Struct Biol 116, 190-199. PMID: 8742743; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8742743

Agrawal, R.K., Penczek, P., Grassucci, R.A., Li, Y., Leith, A., Nierhaus, K.H., and Frank, J. (1996). Direct visualization of A-, P-, and E-site transfer RNAs in the Escherichia coli ribosome. Science 271, 1000-1002. PMID: 8584922; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8584922

Srivastava, S., Verschoor, A., Radermacher, M., Grassucci, R., and Frank, J. (1995). Three-dimensional reconstruction of mammalian 40 S ribosomal subunit embedded in ice. J Mol Biol 245, 461-466. PMID: 7844819; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7844819

Penczek, P., Marko, M., Buttle, K., and Frank, J. (1995). Double-tilt electron tomography. Ultramicroscopy 60, 393-410. PMID: 8525550; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8525550

Liu, Y., Penczek, P.A., McEwen, B.F., and Frank, J. (1995). A marker-free alignment method for electron tomography. Ultramicroscopy 58, 393-402. PMID: 7571119; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7571119

Liu, W., and Frank, J. (1995). Estimation of variance distribution in three-dimensional reconstruction. I. Theory. J Opt Soc Am A Opt Image Sci Vis 12, 2615-2627. PMID: 7500221; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7500221

Liu, W., Boisset, N., and Frank, J. (1995). Estimation of variance distribution in three-dimensional reconstruction. II. Applications. J Opt Soc Am A Opt Image Sci Vis 12, 2628-2635. PMID: 7500222; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7500222

Lata, K.R., Penczek, P., and Frank, J. (1995). Automatic particle picking from electron micrographs. Ultramicroscopy 58, 381-391. PMID: 7571118; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7571118

Frank, J., Zhu, J., Penczek, P., Li, Y., Srivastava, S., Verschoor, A., Radermacher, M., Grassucci, R., Lata, R.K., and Agrawal, R.K. (1995). A model of protein synthesis based on cryo-electron microscopy of the E. coli ribosome. Nature 376, 441-444. PMID: 7630422; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7630422

Frank, J., and Penczek, P. (1995). On the correction of the contrast transfer function in biological electron microscopy. Optik 98, 125-129. PMID: PMCid:

Boisset, N., Penczek, P., Taveau, J.C., Lamy, J., and Frank, J. (1995). Three-dimensional reconstruction of Androctonus australis hemocyanin labeled with a monoclonal Fab fragment. J Struct Biol 115, 16-29. PMID: 7577229; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7577229

Radermacher, M., Rao, V., Grassucci, R., Frank, J., Timerman, A.P., Fleischer, S., and Wagenknecht, T. (1994). Cryo-electron microscopy and three-dimensional reconstruction of the calcium release channel/ryanodine receptor from skeletal muscle. J Cell Biol 127, 411-423. PMID: 7929585; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7929585

Penczek, P.A., Grassucci, R.A., and Frank, J. (1994). The ribosome at improved resolution: new techniques for merging and orientation refinement in 3D cryo-electron microscopy of biological particles. Ultramicroscopy 53, 251-270. PMID: 8160308; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8160308

Mannella, C.A., Marko, M., Penczek, P., Barnard, D., and Frank, J. (1994). The internal compartmentation of rat-liver mitochondria: tomographic study using the high-voltage transmission electron microscope. Microsc Res Tech 27, 278-283. PMID: 8186446; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8186446

Lambert, O., Boisset, N., Penczek, P., Lamy, J., Taveau, J.C., Frank, J., and Lamy, J.N. (1994). Quaternary structure of Octopus vulgaris hemocyanin. Three-dimensional reconstruction from frozen-hydrated specimens and intramolecular location of functional units Ove and Ovb. J Mol Biol 238, 75-87. PMID: 8145258; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8145258

Boisset, N., Penczek, P., Pochon, F., Frank, J., and Lamy, J. (1994). Three-dimensional reconstruction of human alpha 2-macroglobulin and refinement of the localization of thiol ester bonds with monomaleimido nanogold. Ann N Y Acad Sci 737, 229-244. PMID: 7524399; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7524399

McEwen, B.F., Arena, J.T., Frank, J., and Rieder, C.L. (1993). Structure of the colcemid-treated PtK1 kinetochore outer plate as determined by high voltage electron microscopic tomography. J Cell Biol 120, 301-312. PMID: 8421050; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8421050

Frank, J., Chiu, W., and Henderson, R. (1993). Flopping polypeptide chains and Suleika's subtle imperfections: analysis of variations in the electron micrograph of a purple membrane crystal. Ultramicroscopy 49, 387-396. PMID: 8475603; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8475603

Boisset, N., Radermacher, M., Grassucci, R., Taveau, J.C., Liu, W., Lamy, J., Frank, J., and Lamy, J.N. (1993). Three-dimensional immunoelectron microscopy of scorpion hemocyanin labeled with a monoclonal Fab fragment. J Struct Biol 111, 234-244. PMID: 8003384; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8003384

Boisset, N., Penczek, P., Pochon, F., Frank, J., and Lamy, J. (1993). Three-dimensional architecture of human alpha 2-macroglobulin transformed with methylamine. J Mol Biol 232, 522-529. PMID: 7688427; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7688427

Wilson, C.J., Mastronarde, D.N., McEwen, B., and Frank, J. (1992). Measurement of neuronal surface area using high-voltage electron microscope tomography. Neuroimage 1, 11-22. PMID: 9343554; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9343554

Srivastava, S., Verschoor, A., and Frank, J. (1992). Eukaryotic initiation factor 3 does not prevent association through physical blockage of the ribosomal subunit-subunit interface. J Mol Biol 226, 301-304. PMID: 1640449; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=1640449

Radermacher, M., Wagenknecht, T., Grassucci, R., Frank, J., Inui, M., Chadwick, C., and Fleischer, S. (1992). Cryo-EM of the native structure of the calcium release channel/ryanodine receptor from sarcoplasmic reticulum. Biophys J 61, 936-940. PMID: 1316182; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=1316182

Penczek, P., Radermacher, M., and Frank, J. (1992). Three-dimensional reconstruction of single particles embedded in ice. Ultramicroscopy 40, 33-53. PMID: 1580010; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=1580010

Morgan, D.G., Grant, R.A., Chiu, W., and Frank, J. (1992). Patch averaging of electron images of GP3*I crystals with variable thickness. J Struct Biol 108, 245-256. PMID: 1335748; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=1335748

Frank, J., and Radermacher, M. (1992). Three-dimensional reconstruction of single particles negatively stained or in vitreous ice. Ultramicroscopy 46, 241-262. PMID: 1336233; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=1336233

Boisset, N., Grassucci, R., Penczek, P., Delain, E., Pochon, F., Frank, J., and Lamy, J.N. (1992). Three-dimensional reconstruction of a complex of human alpha 2-macroglobulin with monomaleimido Nanogold (Au1.4nm) embedded in ice. J Struct Biol 109, 39-45. PMID: 1283687; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=1283687

Barnard, D.P., Turner, J.N., Frank, J., and McEwen, B.F. (1992). A 360 degrees single-axis tilt stage for the high-voltage electron microscope. J Microsc 167, 39-48. PMID: 1527794; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=1527794

Woodcock, C.L., McEwen, B.F., and Frank, J. (1991). Ultrastructure of chromatin. II. Three-dimensional reconstruction of isolated fibers. J Cell Sci 99 ( Pt 1), 107-114. PMID: 1757495; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=1757495

Frank, J., Penczek, P., Grassucci, R., and Srivastava, S. (1991). Three-dimensional reconstruction of the 70S Escherichia coli ribosome in ice: the distribution of ribosomal RNA. J Cell Biol 115, 597-605. PMID: 1918155; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=1918155

Verschoor, A., and Frank, J. (1990). Three-dimensional structure of the mammalian cytoplasmic ribosome. J Mol Biol 214, 737-749. PMID: 2388265; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=2388265

Carazo, J.M., Rivera, F.F., Zapata, E.L., Radermacher, M., and Frank, J. (1990). Fuzzy sets-based classification of electron microscopy images of biological macromolecules with an application to ribosomal particles. J Microsc 157, 187-203. PMID: 2179560; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=2179560

Boisset, N., Taveau, J.C., Lamy, J., Wagenknecht, T., Radermacher, M., and Frank, J. (1990). Three-dimensional reconstruction of native Androctonus australis hemocyanin. J Mol Biol 216, 743-760. PMID: 2258938; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=2258938

Wagenknecht, T., Grassucci, R., Frank, J., Saito, A., Inui, M., and Fleischer, S. (1989). Three-dimensional architecture of the calcium channel/foot structure of sarcoplasmic reticulum. Nature 338, 167-170. PMID: 2537473; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=2537473

Wagenknecht, T., Carazo, J.M., Radermacher, M., and Frank, J. (1989). Three-dimensional reconstruction of the ribosome from Escherichia coli. Biophys J 55, 455-464. PMID: 2649163; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=2649163

Verschoor, A., Zhang, N.Y., Wagenknecht, T., Obrig, T., Radermacher, M., and Frank, J. (1989). Three-dimensional reconstruction of mammalian 40 S ribosomal subunit. J Mol Biol 209, 115-126. PMID: 2810364; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=2810364

Unser, M., Trus, B.L., Frank, J., and Steven, A.C. (1989). The spectral signal-to-noise ratio resolution criterion: computational efficiency and statistical precision. Ultramicroscopy 30, 429-433. PMID: 2800044; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=2800044

Carazo, J.M., Wagenknecht, T., and Frank, J. (1989). Variations of the three-dimensional structure of the Escherichia coli ribosome in the range of overlap views. An application of the methods of multicone and local single-cone three-dimensional reconstruction. Biophys J 55, 465-477. PMID: 2649164; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=2649164

Wagenknecht, T., Grassucci, R., and Frank, J. (1988). Electron microscopy and computer image averaging of ice-embedded large ribosomal subunits from Escherichia coli. J Mol Biol 199, 137-147. PMID: 2451023; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=2451023

Wagenknecht, T., Frank, J., Boublik, M., Nurse, K., and Ofengand, J. (1988). Direct localization of the tRNA--anticodon interaction site on the Escherichia coli 30 S ribosomal subunit by electron microscopy and computerized image averaging. J Mol Biol 203, 753-760. PMID: 3062179; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=3062179

Saito, A., Inui, M., Radermacher, M., Frank, J., and Fleischer, S. (1988). Ultrastructure of the calcium release channel of sarcoplasmic reticulum. J Cell Biol 107, 211-219. PMID: 2455723; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=2455723

Frank, J., Chiu, W., and Degn, L. (1988). The characterization of structural variations within a crystal field. Ultramicroscopy 26, 345-360. PMID: 3238812; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=3238812

Frank, J., Bretaudiere, J.P., Carazo, J.M., Verschoor, A., and Wagenknecht, T. (1988). Classification of images of biomolecular assemblies: a study of ribosomes and ribosomal subunits of Escherichia coli. J Microsc 150, 99-115. PMID: 3045323; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=3045323

Carazo, J.M., Wagenknecht, T., Radermacher, M., Mandiyan, V., Boublik, M., and Frank, J. (1988). Three-dimensional structure of 50 S Escherichia coli ribosomal subunits depleted of proteins L7/L12. J Mol Biol 201, 393-404. PMID: 3047401; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=3047401

Carazo, J.M., and Frank, J. (1988). Three-dimensional matching of macromolecular structures obtained from electron microscopy: an application to the 70S and 50S E. coli ribosomal particles. Ultramicroscopy 25, 13-22. PMID: 3291355; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=3291355

Boisset, N., Frank, J., Taveau, J.C., Billiald, P., Motta, G., Lamy, J., and Sizaret, P.Y. (1988). Intramolecular localization of epitopes within an oligomeric protein by immunoelectron microscopy and image processing. Proteins 3, 161-183. PMID: 2474818; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=2474818

Radermacher, M., Wagenknecht, T., Verschoor, A., and Frank, J. (1987). Three-dimensional structure of the large ribosomal subunit from Escherichia coli. EMBO J 6, 1107-1114. PMID: 3297672; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=3297672

Radermacher, M., Wagenknecht, T., Verschoor, A., and Frank, J. (1987). Three-dimensional reconstruction from a single-exposure, random conical tilt series applied to the 50S ribosomal subunit of Escherichia coli. J Microsc 146, 113-136. PMID: 3302267; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=3302267

Mannella, C.A., Ribeiro, A.J., and Frank, J. (1987). Cytochrome c binds to lipid domains in arrays of mitochondrial outer membrane channels. Biophys J 51, 221-226. PMID: 3030457; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=3030457

Mannella, C.A., Frank, J., and Delihas, N. (1987). Interrelatedness of 5S RNA sequences investigated by correspondence analysis. J Mol Evol 24, 228-235. PMID: 3106638; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=3106638

Verschoor, A., Frank, J., Wagenknecht, T., and Boublik, M. (1986). Computer-averaged views of the 70 S monosome from Escherichia coli. J Mol Biol 187, 581-590. PMID: 3519978; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=3519978

Tsuji, M., Frank, J., and Manley, R.S.J. (1986). Image analysis in the electron microscopy of cellulose protofibrils. II: Digital correlation methods. Colloid and Polymer Science 264, 89-96. PMID: PMCid:

Radermacher, M., Wagenknecht, T., Verschoor, A., and Frank, J. (1986). A new 3-D reconstruction scheme applied to the 50S ribosomal subunit of E. coli. J Microsc 141, RP1-2. PMID: 3514918; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=3514918

McEwen, B.F., Radermacher, M., Rieder, C.L., and Frank, J. (1986). Tomographic three-dimensional reconstruction of cilia ultrastructure from thick sections. Proc Natl Acad Sci U S A 83, 9040-9044. PMID: 3466176; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=3466176

Mannella, C.A., Ribeiro, A., and Frank, J. (1986). Structure of the channels in the outer mitochondrial membrane: Electron microscopic studies of the periodic arrays induced by phospholipase A2 treatment of the Neurospora membrane. Biophysical Journal 49, 307-317. PMID: PMCid: http://www.biophysj.org/cgi/content/abstract/49/1/307

Mannella, C.A., and Frank, J. (1986). Effect of succinylation on images of negatively stained arrays of mitochondrial outer membrane channels. J Ultrastruct Mol Struct Res 96, 31-40. PMID: 2445865; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=2445865

Bretaudiere, J.P., and Frank, J. (1986). Reconstitution of molecule images analysed by correspondence analysis: a tool for structural interpretation. J Microsc 144, 1-14. PMID: 3632765; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=3632765

Verschoor, A., Frank, J., and Boublik, M. (1985). Investigation of the 50 S ribosomal subunit by electron microscopy and image analysis. J Ultrastruct Res 92, 180-189. PMID: 3913778; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=3913778

Subirana, J.A., Munoz-Guerra, S., Aymami, J., Radermacher, M., and Frank, J. (1985). The layered organization of nucleosomes in 30 nm chromatin fibers. Chromosoma 91, 377-390. PMID: 4039646; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=4039646

Radermacher, M., and Frank, J. (1985). Use of nonlinear mapping in multivariate image analysis of molecule projections. Ultramicroscopy 17, 117-126. PMID: 4071832; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=4071832

Parsons, D.F., Marko, M., Radermacher, M., and Frank, J. (1985). Shape changes and polarization of cells migrating through tissue. A high-voltage electron microscope and computer graphics study of serial thick sections. Tissue Cell 17, 491-510. PMID: 4049363; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=4049363

Lamy, J., Billiald, P., Sizaret, P.Y., Cave, G., Frank, J., and Motta, G. (1985). Approach to the direct intramolecular localization of antigenic determinants in Androctonus australis hemocyanin with monoclonal antibodies by molecular immunoelectron microscopy. Biochemistry 24, 5532-5542. PMID: 2416343; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=2416343

Kim, C.H., Radermacher, M., Kessel, M., Frank, J., and King, T.E. (1985). Three-dimensional reconstruction of cytochrome oxidase vesicle crystals prepared by cholate solubilization. J Inorg Biochem 23, 163-169. PMID: 2991453; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=2991453

Kessel, M., Radermacher, M., and Frank, J. (1985). The structure of the stalk surface layer of a brine pond microorganism: correlation averaging applied to a double layered lattice structure. J Microsc 139, 63-74. PMID: 4046014; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=4046014

Hui, S.W., and Frank, J. (1985). Analysis of the irregular planar distribution of proteins in membranes. J Microsc 137, 293-303. PMID: 3999133; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=3999133

Woodcock, C.L., and Frank, J. (1984). Nucleosome mass distribution using image averaging. J Ultrastruct Res 89, 295-302. PMID: 6544891; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=6544891

Wagenknecht, T., and Frank, J. (1984). Localization of lipoyl-bearing domains in the alpha-ketoglutarate dehydrogenase multienzyme complex. Biochemistry 23, 3383-3389. PMID: 6380587; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=6380587

Verschoor, A., Frank, J., Radermacher, M., Wagenknecht, T., and Boublik, M. (1984). Three-dimensional reconstruction of the 30 S ribosomal subunit from randomly oriented particles. J Mol Biol 178, 677-698. PMID: 6387155; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=6387155

Radermacher, M., and Frank, J. (1984). Representation of three-dimensionally reconstructed objects in electron microscopy by surfaces of equal density. J Microsc 136, 77-85. PMID: 6392559; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=6392559

Mannella, C.A., and Frank, J. (1984). Electron microscopic stains as probes of the surface charge of mitochondrial outer membrane channels. Biophysical Journal 45, 139-141. PMID: PMCid: http://www.biophysj.org/cgi/reprint/45/1/139

Haenicke, W., Frank, J., and Zingsheim, H.P. (1984). Statistical significance of molecule projections by single particle averaging. J Microsc 133, 223-238. PMID: 6708102; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=6708102

Frank, J., and Wagenknecht, T. (1984). Automatic selection of molecular images from electron micrographs. Ultramicroscopy 12, 169–176. PMID: PMCid: http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WM5-4B72221-4&_user=18704&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_version=1&_urlVersion=0&_userid=18704&md5=4e51815fee50283760aa9302464919bb

Mannella, C.A., Colombini, M., and Frank, J. (1983). Structural and functional evidence for multiple channel complexes in the outer membrane of Neurospora crassa mitochondria. Proc Natl Acad Sci U S A 80, 2243-2247. PMID: 6300902; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=6300902

Zingsheim, H.P., Neugebauer, D.C., Frank, J., Hanicke, W., and Barrantes, F.J. (1982). Dimeric arrangement and structure of the membrane-bound acetylcholine receptor studied by electron microscopy. EMBO J 1, 541-547. PMID: 7188351; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7188351

Zingsheim, H.P., Barrantes, F.J., Frank, J., Hanicke, W., and Neugebauer, D.C. (1982). Direct structural localization of two toxin-recognition sites on an ACh receptor protein. Nature 299, 81-84. PMID: 7110329; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7110329

Sizaret, P.Y., Frank, J., Lamy, J., Weill, J., and Lamy, J.N. (1982). A refined quaternary structure of Androctonus australis Hemocyanin. Eur J Biochem 127, 501-506. PMID: 7173191; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7173191

Mannella, C., and Frank, J. (1982). Effects of divalent metal ions and chelators on the structure of the outer mitochondrial membranes from Neurospora crassa. Biophysical Journal 37, 3-4. PMID: PMCid: http://www.biophysj.org/cgi/reprint/37/1/3.pdf

Lamy, J., Sizaret, P.Y., Frank, J., Verschoor, A., Feldmann, R., and Bonaventura, J. (1982). Architecture of Limulus polyphemus hemocyanin. Biochemistry 21, 6825-6833. PMID: 7159564; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7159564

Frank, J., Verschoor, A., and Boublik, M. (1982). Multivariate statistical analysis of ribosome electron micrographs. L and R lateral views of the 40 S subunit from HeLa cells. J Mol Biol 161, 107-133. PMID: 6185684; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=6185684

Frank, J., and van Heel, M. (1982). Correspondence analysis of aligned images of biological particles. J Mol Biol 161, 134-137. PMID: 7154073; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7154073

Frank, J. (1982). New methods for averaging non periodic objects and distorted crystals in biologic electron microscopy. Optik 63, 67-69. PMID: PMCid:

Frank, J. (1982). Methods for studying the dynamic behavior of biological macromolecules. Ultramicroscopy 9, 3-8. PMID: 7135629; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7135629

van Heel, M., and Frank, J. (1981). Use of multivariate statistics in analysing the images of biological macromolecules. Ultramicroscopy 6, 187-194. PMID: 7268930; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7268930

Frank, J., Verschoor, A., and Boublik, M. (1981). Computer averaging of electron micrographs of 40S ribosomal subunits. Science 214, 1353-1355. PMID: 7313694; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7313694

Frank, J., Shimkin, B., and Dowse, H. (1981). SPIDER A modular software system for image processing. Ultramicroscopy 6, 343. PMID: PMCid:

Zingsheim, H.P., Neugebauer, D.C., Barrantes, F.J., and Frank, J. (1980). Structural details of membrane-bound acetylcholine receptor from Tropedo marmorata. Proc Natl Acad Sci U S A 77, 952-956. PMID: 6928692; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=6928692

Kessel, M., Frank, J., and Goldfarb, W. (1980). Averages of glutamine synthetase molecules as obtained with various skin and electron dose conditions. J Supramol Struct 14, 405-422. PMID: 6165866; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=6165866

Al-Ali, L., and Frank, J. (1980). Resolution estimation in electron microscopy. Optik 56, 31. PMID: PMCid:

Frank, J., Goldfarb, W., Eisenberg, D., and Baker, T.S. (1979). Addendum to "reconstruction of glutamine synthetase using computer averaging". Ultramicroscopy 04, 247. PMID: 38551; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=38551

Frank, J., McFarlane, S.C., and Downing, K.H. (1978). A note on the effect of source size and defocus spread in bright field electron microscopy. Optik 52, 49-60. PMID: PMCid:

Frank, J., Goldfarb, W., Eisenberg, D., and Baker, T.S. (1978). Reconstruction of glutamine synthetase using computer averaging. Ultramicroscopy 3, 283-290. PMID: 32653; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=32653

Wade, R.H., and Frank, J. (1977). Electron microscopic transfer functions for partially coherent axial illumination and chromatic defocus spread. Optik 49, 81-92 PMID: PMCid:

Saxton, W.O., and Frank, J. (1977). Motif detection in quantum noise-limited electron micrographs by cross-correlation. Ultramicroscopy 2, 219-227. PMID: 888241; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=888241

Frank, J. (1976). Determination of source size and energy spread from electron micrographs using the method of Young's fringes. Optik 44, 379-391. PMID: PMCid:

Frank, J., and Al-Ali, L. (1975). Signal-to-noise ratio of electron micrographs obtained by cross correlation. Nature 256, 376-379. PMID: 1095934; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=1095934

Frank, J. (1975). Partial coherence and efficient use of electrons in bright field electron microscopy. Optik 43, 103-109. PMID: PMCid:

Frank, J. (1975). Controlled focusing and stigmating in the conventional and scanning transmission electron microscope. Journal of Physics E: Scientific Instruments 8, 582-587 PMID: PMCid:

Frank, J. (1975). A practical resolution criterion in optics and electron microscopy. Optik 43, 25-34. PMID: PMCid:

Frank, J. (1975). Averaging of low exposure electron micrographs of non-periodic objects. Ultramicroscopy 1, 159-162. PMID: 1236029; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=1236029

Frank, J. (1974/75). Phasenbestimmung and Beruecksichtigung der Linsenfehler in der Elektronenmikroskopie; eine Klarstellung. Optik 41, 90-91. PMID: PMCid:

Frank, J. (1974). Radiation damage assessment from electron images using digital correlation methods. Journal of Physics D: Applied Physics 7, L75-L78 PMID: PMCid:

Frank, J. (1973). The envelope of electron microscopic transfer functions for partially coherent illumination. Optik 38, 519-539 PMID: PMCid:

Frank, J. (1972). Observation of the relative phases of electron microscopic phase contrast zones with the aid of the optical diffractometer. Optik 35, 608-612 PMID: PMCid:

Frank, J. (1972). A study of heavy-light atom discrimination in bright-field electron microscopy using the computer. Biophys J 12, 484-511. PMID: 5030562; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=5030562

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Title Adiga, U., Baxter, W.T., Hall, R.J., Rockel, B., Rath, B.K., Frank, J., and Glaeser, R. (2005). Particle picking by segmentation: a comparative study with SPIDER-based manual particle picking. J Struct Biol 152, 211-220. PMID: 16330229; PMCid: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16330229