Relevant Publications:

• C. Kellendonk, E. Simpson, H.J. Polan, G. Malleret, S. Vronskaya, V. Winiger, H. Moore, E.R. Kandel    (2006)  Transient and Selective Over-Expression of Dopamine D2 Receptors in the Striatum Causes Persistent Abnormalities in the Prefrontal Cortex. Neuron 49, 603-615
• M. Drew, E.H. Simpson, C. Kellendonk, G. Herzberg, O. Olipatov, S. Fairhurst, E.R. Kandel, C. Malapani, P. Balsam (2007) Transient overexpression of striatal D2 receptors impairs operant motivation and interval timing. J. Neuroscience  27: 7731-9
• M.E. Bach, E.H. Simpson, L. Kahn, J. Marshall, E.R. Kandel, C. Kellendonk (2008) Transient and selective over-expression of D2 receptors in the striatum causes persistent deficits in conditioned associative learning. Proc. Natl. Ac. Sci. U S A 105(41):16027-32
• C. Kellendonk, E.H. Simpson, E.R. Kandel (2009) Modeling Schizophrenia Endophenotypes in Mice. Trends Neurosc, 32(6):347-358
• R. Ward, C. Kellendonk, E.H. Simpson, O. Lipotova, M. Drew, S. Fairhurst, E.R. Kandel, P. Balsam (2009) Impaired timing precision produced by striatal D2 receptor overexpression is mediated by cognitive and motivational deficits. Behav Neurosci.123(4):720-30.
• C. Kellendonk (2009) Modeling excess striatal D2 receptors in mice. Prog Brain Res159:59-65
• E.H. Simpson, C. Kellendonk, E.R. Kandel (2010) A possible role for the Striatum in the Pathogenesis of the Cognitive Symptoms of Schizophrenia. Neuron 65: 585-596
• A.M. Miller, R. Bansal, X. Hao, J. P. Sanchez-Pena, L.J. Miller, J. Liu, D. Xu, H. Zhu, M.M. Chakravarty, K. Durkin, I. Ivanov, K.J. Plessen, C. Kellendonk, B.S. Peterson (2010) Enlargement of thalamic motor nuclei in persons with Tourette Syndrome. Archives of General Psychiatry 67(9):955-64
• M. Cazorla, J. Prémont, A. Mann, N. Girard, C. Kellendonk, D. Rognan (2011) Virtual screening identifies a low-molecular weight TrkB antagonist with anxiolytic and antidepressant potential in mice Journal of Clinical Investigation 121:1846-57
• E.H. Simpson, C. Kellendonk, R.D. Ward, V. Richards, O. Lipatova, S. Fairhurst, E.R. Kandel, P.D. Balsam (2011) Pharmacologic rescue of motivational deficit in an animal model of the negative symptoms of Schizophrenia. Biol. Psychiatry 69:928-35
• Li YC, Kellendonk C, Simpson EH, Kandel ER, Gao WJ. (2011) D2 receptor overexpression in the striatum leads to a deficit in inhibitory transmission and dopamine sensitivity in mouse prefrontal cortex. Proc Natl Acad Sci U S A 108:12107-12
• M. Cazorla, Shegda M., Harrison N., Kellendonk C. (2012) Striatal D2 receptors regulate dendritic morphology of medium spiny neurons via Kir2 channels J. Neuroscience 32: 2398-409
  

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