The King's College Medical School opened in the fall of 1767, boasting an impressive faculty of New York's leading medical men. Among them was Samuel Bard (1742-1821), who served as dean and would later win fame as physician to George Washington during his first term as President. The medical school, along with the rest of the college, closed in 1776 as a result of the disruptions of the American Revolution. These notes of Bard's lectures taken by medical student James Graham in 1774 are the only ones from the pre-revolutionary school now in the possession of the University.

Graham did not receive a medical degree from King's, but he later practiced medicine in Walkill, New York.