Jung-Chi Liao
220 S. W. Mudd, Mail Code: 4703
Phone: +1 212-851-0782
Fax: +1 212-854-3304
Email:
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Jung-Chi Liao is an assistant professor of mechanical engineering at Columbia University. He received his Ph.D. from MIT in 2002. His current research interests include molecular motors, which are ubiquitous protein nanomachines that convert chemical energy (e.g. ATP hydrolysis) into mechanical work to perform diverse functions, such as gene replication, cell division, cell migration, axonal transport, and many other functions. Several of these functions are related to serious diseases including heart failure and cancer. He is interested in understanding how molecular motors play their key roles in these disease-related functions. Specifically he is investigating dynamics, regulation, protein interactions, and force generation of molecular motors. His research integrates multidisciplinary approaches, including computational modeling and simulation, single molecule biophysics, biochemistry, molecular biology, applied mechanics, and bioinformatics.
PhD, MS, and undergraduate research opportunities are available.
Publications
·Liao, J.-C., Elting, M.W., Delp, S.L., Spudich, J.A., Bryant, Z. (2008) Probing structural effects on directionality and processivity of myosin VI. (in preparation)
·Zheng, W., Liao, J.-C., Doniach, S., Brooks, B.R. (2007) Toward the mechanism of dynamical couplings in hepatitis C virus NS3 helicase using elastic network model. Proteins: Structure, Function, and Bioinformatics, 67, 886-896.
·Tang, S., Liao, J.-C., Dunn, A., Altman, R.B., Spudich, J.A., Schmidt, J. (2007) Predicting allosteric communication in myosin via a pathway of conserved residues. Journal of Molecular Biology, 373(5), 1361-1373.
·Liao, J.-C., Spudich, J.A., Parker, D., Delp, S.L. (2007) Extending the absorbing boundary method to fit dwell-time distributions of molecular motors with complex kinetic pathways. Proceedings of the National Academy of Sciences, USA, 104, 3171-3716.
·Adelman, J.L., Jeong, Y.-J., Liao, J.-C., Patel, G., Kim, D.-E., Oster, G., Patel, S. S. (2006) Mechanochemistry of transcription termination factor Rho. Molecular Cell, 22, 611-621.
·Xing, J., Liao, J.-C., Oster, G. (2005) Making ATP. Proceedings of the National Academy of Sciences, USA, 102(46), 16539-16546.
·Liao, J.-C., Jeong, Y., Kim, D.-E., Patel, S. S., Oster, G. (2005) Mechanochemistry of T7 DNA helicase. Journal of Molecular Biology, 350(3), 452-575.
· Liao, J.-C., Sun, S., Chandler, D., Oster, G. (2004) The conformational states of Mg-ATP in water. European Biophysical Journal, 33, 29-37.