Qiao Lin
236 S. W. Mudd, Mail Code: 4703
Phone: +1 212-854-1906
Fax: +1 212-854-3304
Email:
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Qiao Lin conducts research in the area of microelectromechanical systems (MEMS) with applications to biology and medicine. Current research is focused on designing and creating micro/nanosystems, in particular, microelectromechanical systems (MEMS) and micro/nanofluidic systems, for controlling the motion and measuring the dynamic behavior, such as conformational transitions, and interactions and reactions of biomolecules in solution. The goal of these systems is primarily to facilitate understanding of fundamental biophysical phenomena, and to enable practical biomedical applications. These systems will allow automated, sensitive, high-throughput analysis of biological systems within well-controlled micro- and nanoscale environments, and may enable novel biological investigations not attainable by conventional methods.
Professor Lin directs the Columbia BioMEMS Laboratory. Research projects in the laboratory primarily include aptameric microfluidics, implantable MEMS affinity biosensors, MEMS-based characterization of temperature-dependent biomolecular behavior, polymer-enhanced microflow control, and BioMEMS modeling. Examples of results from these projects include microfluidic purification systems using thermally controlled, reversible aptamer-target binding; MEMS continuous glucose sensors using viscometric and dielectric affinity assays; MEMS biocalorimeters; compliance-based microflow control devices; and efficient and accurate microfluidic models.
Publications
W.Y. Ma, J. Yao, H. Yang, J.Y. Liu, F. Li, J.P. Hilton and Q. Lin, "Effects of Vertex Truncation of Polyhedral Nanostructures on Localized Surface Plasmon Resonance," Optics Express. In Press.
B. Yang and Q. Lin, "A Latchable Phase-Change Microvalve with Integrated Heaters," J. of Microelectromechanical Systems. In Press.
X. Huang, S. Li, J. Schultz, Q. Wang and Q. Lin, "A MEMS Continuous Glucose Monitoring Device Using a Biocompatible Sensing Fluid," Sensors and Actuators B: Chemical, 140: 603-609, 2009.
S. Li, E. Davis, J. Anderson, Q. Lin and Q. Wang, "Development of Boronic Acid Grafted Random Copolymers for Continuous Glucose Monitoring," Biomacromolecules, 10: 113-118, 2009.
T.H. Nguyen, J.P. Hilton, and Q. Lin, "Emerging Applications of Aptamers to micro- and nanoscale biosensing", Microfluidics and Nanofluidics, 6: 347-362, 2009.
T.H. Nguyen, R. Pei, M. Stojanovic and Q. Lin, "An Aptamer-Based Microfluidic Device for Thermally Controlled Affinity Extraction," Microfluidics and Nanofluidics, 6: 479-487, 2009.
Y. Zhou, Y. Wang, T. Mukherjee and Q. Lin, "Generation of Complex Concentration Profiles by Partial Diffusive Mixing in Multi-Stream Laminar Flow," Lab on a Chip, 9: 1439-1448, 2009.
B. Yang and Q. Lin, "A Compliance-Based Microflow Stabilizer," J. of Microelectromechanical Systems, 18: 539-546, 2009.
B. Yang and Q. Lin, "A Latchable Phase-Change Microvalve with Integrated Heaters," J. of Microelectromechanical Systems, 18: 860-867, 2009
S. Li, X. Huang, E. Davis, Q. Lin and Q. Wang, "Development of Novel Glucose Sensing Fluids with Application to MEMS-Based Continuous Glucose Monitoring," J. of Diabetes Science and Technology, 2: 1066-1074, 2008.
L. Wang, D. Sipe and Q. Lin, "A MEMS Thermal Biosensor for Metabolic Monitoring Applications," J. of Microelectromechanical Systems, 17: 318-327, 2008.
L. Wang, B. Wang, and Q. Lin, "Demonstration of MEMS-Based Differential Scanning Calorimetry for Determining Thermodynamic Properties of Biomolecules," Sensors and Actuators B: Chemical, 134: 953-958, 2008.
X. Huang, C.-M. Cheng, L. Wang, C.-C. Su, M.-S. Ho, P. LeDuc and Q. Lin, "Thermally Tunable Polymer Microlens," Applied Physics Letters, 92, 251904, 2008.
K. Zheng, W. Khalid, Z. Wang, Y. Li, R. B. Katragadda, Y. Zhao, Q. Lin and Y. Xu, "Optical Lever Based Parylene Cantilevers for Biochemical Sensing", The Open Optics J., 2: 86-93, 2008.
J. Huang, B. Cusick, J. Pietrasik, L. Wang, T. Kowalewski, Q. Lin and K. Matyjaszewski, "Synthesis and In Situ Atomic Force Microscopy Characterization of Temperature-Responsive Hydrogels Based on Poly(2-(Dimethylamino)Ethyl Methacrylate) Prepared by Atom Transfer Radical Polymerization," Langmuir, 23: 241-249, 2007.
A. Kusumo, L. Bombalski, Q. Lin, K. Matyjaszewski, T. Kowalewski, J. W. Schneider and R. D. Tilton, "High Capacity, Charge-Selective Protein Uptake by Polyelectrolyte Brushes," Langmuir, 23: 4448-4454, 2007.
B. Yang and Q. Lin, "A Planar Compliance-Based Self-Adaptive Microfluid Variable Resistor," J. of Microelectromechanical Systems, 16: 411-419, 2007.
B. Yang and Q. Lin, "Planar Micro Check Valves Exploiting Large Polymer Compliance," Sensors and Actuators A: Physical, 134: 186-193, 2007.
B. Yang and Q. Lin, "A Latchable Micro Valve Using Phase Change of Paraffin Wax," Sensors and Actuators A: Physical, 134: 194-200, 2007.
Y.J. Zhao, S. Li, A. Davidson, B. Yang, Q. Wang and Q. Lin, "A MEMS Viscometric Sensor for Continuous Glucose Monitoring," J. of Micromechanics and Microengineering, 17: 2528-2537, 2007.
Q. Lin, B. Yang, J. Xie and Y.C. Tai, "Dynamic simulation of a peristaltic micropump considering coupled fluid flow and structural motion," J. of Micromechanics and Microengineering, 17: 220-228, 2006.
Y. Wang, T. Mukherjee and Q. Lin, "Systematic Modeling of Microfluidic Concentration Gradient Generators," J. of Micromechanics and Microengineering, 16: 2128-2137, 2006.
Y. Wang, Q. Lin and T. Mukherjee, "Composable Behavioral Models and Schematic-Based Simulation of Electrokinetic Lab-on-a-Chip Systems," IEEE Trans. on Computer-Aided Design of Integrated Circuits and Systems, 25: 258-273, 2006.
B. Yang, B. Aksak, Q. Lin, and M. Sitti, "Compliant and Low-Cost Humidity Nanosensors using Nanoporous Polymer Membranes," Sensors and Actuators, B: Chemical, 114: 254-262, 2006.
G.D. Ehrlich, P. Stoodley, S. Kathju, Y.J. Zhao, B.R. Mcleod, N. Baliban, F.Z. Hu, N.G. Sotereanos, J.W. Costerton, P.S. Stewart, J.C. Post, and Q. Lin, "Engineering Approaches for the Detection and Control of Orthopedic Biofilm Infections," Clinical Orthpaedics and Related Research, 437: 59-66, 2005.
Q. Lin, Y. Xu, F. Jiang, Y.C. Tai and C.M. Ho, "A Parametrized Three-Dimensional Model for MEMS Thermal Shear-Stress Sensors," J. of Microelectromechanical Systems, 14: 625- 633, 2005.
Y. Wang, Q. Lin and T. Mukherjee, "A Model for Laminar Diffusion-Based Complex Electrokinetic Passive Micromixers," Lab on a Chip, 5: 877-887, 2005.
Y. Xu, C.W. Chiu, F. Jiang, Q. Lin and Y.C. Tai, "A MEMS Multi-Sensor Chip for Flow Sensing," Sensors and Actuators, A: Physical, 121: 253-261, 2005.
Y. Xu, Q. Lin, G. Lin, F. Jiang, and Y.-C. Tai, "Micromachined Thermal Shear-Stress Sensor for Underwater Applications," J. of Microelectromechanical Systems, 14: 1023-1030, 2005.
G.D. Ehrlich, F.Z. Hu, Q. Lin, J.W. Costerton and J.C. Post, "Intelligent Implants to Battle Biofilms," ASM News, American Society for Microbiology, 70: 127-133, 2004.
Q. Lin, J.W. Burdick and E. Rimon, "Computation and Analysis of Compliance in Grasping and Fixturing," IEEE Trans. on Robotics, 20: 651-667, 2004.
Q. Lin, F. Jiang, X. Wang, Y. Xu, Z. Han, Y.C. Tai, J. Lew and C.M. Ho, "Experiments and Simulations of MEMS Thermal Sensors for Wall Shear Stress Measurements in Aerodynamic Control Applications," J. of Micromechanics and Microengineering, 14: 1640-1649, 2004.
S. Liu, A. Davidson and Q. Lin, "Simulation Studies on Nonlinear Dynamics and Chaos in a MEMS Cantilever Control System," J. of Micromechanics and Microengineering, 14: 1064-1073, 2004.
Y. Wang, Q. Lin and T. Mukherjee, "A Model for Joule Heating-Induced Dispersion in Microchip Electrophoresis," Lab on a Chip, 4: 625-631, 2004.
Y. Wang, Q. Lin and T. Mukherjee, "System-Oriented Dispersion Models of General-Shaped Electrophoresis Microchannels," Lab on a Chip, 4: 453-463, 2004. (Selected as a Hot Article)
J. Xie, J. Shih, Q. Lin, B. Yang and Y.C. Tai, "Surface Micromachined Electrostatically Actuated Micro Peristaltic Pump," Lab on a Chip, 4: 495-501, 2004.
B. Yang, G.C. Lopez, A.J. Rosenbloom and Q. Lin, "Design and Rapid Fabrication of a Microfluidic Fraction Collector," Int. J. of Nonlinear Sciences and Numerical Simulation, 3 (3-4): 267-272, Sp. Iss. SI, 2002.
S. Wu, Q. Lin, Y. Yuen and Y.C. Tai, "MEMS Flow Sensors for Nano-fluidic Applications," Sensors and Actuators A: Physical, 89: 152-158, 2001.