For several decades, most life scientists focused their attention on studies of nucleic acids and the translation of the coded information. Protein degradation was a neglected area of study until discovery of the complex cascade of the ubiquitin pathway revolutionized the field. It is now clear that the degradation of cellular proteins is a highly complex, temporally controlled, and tightly regulated process that plays major roles in a variety of basic pathways during cell life and death, and in health and disease. With the multitude of substrates targeted, and the myriad processes involved, it is not surprising that aberrations in pathways are implicated in the pathogenesis of many diseases, certain malignancies and neurodegeneration among them.
Aaron Ciechanover, a 2004 Nobel laureate in chemistry, will speak on recent insights into the process of the degradation of a protein and discuss how this knowledge impacts developing drugs for targeting specific diseases.
The lecture will be held on Wednesday, April 20, at 6 p.m. in Roone Arledge Cinema, Alfred Lerner Hall. Registration is required. To register, contact Alessandra Garber at (212) 854-4472.