• Anne A. Gershon,MD
• Marc D. Foca, MD
• Philip L. Graham III, MD MSc
• Philip LaRussa, MD
• Natalie M. Neu, MD MPH
• Sameer J. Patel, MD
• Alice Prince, MD
• Adam J. Ratner, MD MPH
• Lisa Saiman, MD MPH

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Alice Prince, MD

EDUCATION Wellesley College, BA, 1971 Columbia University, College of Physicians & Surgeons, MD, 1975 ACADEMIC TITLE Professor of Pediatrics (in Pharmacology) SPECIALTY Pathogenesis of pulmonary infection

RESEARCH AND CLINICAL SUMMARY

Please see the laboratory website (www.columbia.edu/cu/hs/princelab/index.html) for more details.

OFFICE INFORMATION

Alice S. Prince, MD
Columbia University
650 West 168th Street
Black Building 416
New York, NY 10032
Tel : (212) 305-4193
Fax: (212)342-5218
Email: asp7@columbia.edu

SELECTED PUBLICATIONS

• Jarin Chun and Alice Prince. TLR2-induced calpain cleavage of epithelial junctional proteins facilitates leukocyte transmigration. Cell Host and Microbe. 2009 Jan 22;5(1):47-58.
• Francis Martin and Alice Prince. TLR2 Regulates Gap Junction Intercellular Communication in Airway Cells. J Immunol. 2008 Apr 1;180(7):4986-93.
• Grace Soong, Parker D, Magargee M, Prince AS. The type III toxins of P. aeruginosa disrupt epithelial barrier function. J Bacteriol. 2007 Dec 28; [Epub ahead of print]
• Marisa Gomez and Alice Prince. Opportunistic infections in lung disease: Pseudomonas infections in cystic fibrosis. Curr Opin Pharmacol. 2007 Jun;7(3):244-51.Apr 5.
• Valerie Waters, Gomez MI, Soong G, Amin S, Ernst R, Prince A. Immunostimulatory properties of the emerging pathogen Stenotrophomonas maltophilia.Infect Immun. 2007 Apr;75(4):1698-703.
• Marisa Gomez, O'Seaghdha MO, Prince AS. Staphylococcus aureus protein A activates TACE through EGFR-dependent signaling. EMBO J. 2007 Feb 7;26(3):701-9.
• Marisa Gomez, O'Seaghdha M, Magargee M, Foster TJ, Prince A. Staphylococcus aureus protein A activates TNFR1 signaling through conserved IgG binding domains. J Biol Chem. 281:20190-20196, 2006.
• Grace Soong, A Muir, MI Gomez, J Waks, B Rheddy, P Planet, P Singh, Y Kaneko, MC Wolfgang, YS Hsiao, L Tong, A Prince. Bacterial neuraminidase facilitates mucosal infection by participating in biofilm production. J Clin Invest. 116: 2297-2305, 2006
• Alice Prince, Mizgerd, J, Wiener-Kronish, JP , Bhattacharya, J. Cell signaling underlying the pathophysiology of pneumonia. Am J Physiol Lung Cell Mol Physiol. 2006 Sep;291(3):L297-300.
• Jarin Chun and Alice Prince Activation of Ca2+-dependent signaling by TLR2. J Immunol. 177:1330-1337. 2006.
• Alice Prince. Flagellar activation of epithelial signaling. Am J Resp Cell Molec Biol 34:548-551, 2006.
• Valerie Waters. Sokol, S, Soong, G, Reddy, B, Chun, J and Prince A. The effect of cyclosporin A on airway cell proinflammatory signaling and pneumonia. Am J Resp Cell Molec Biol. 33:138-144, 2005.
• Marisa Gomez, Sokol, S, Muir A, Soong G, Bastien J, and Prince A. Bacterial induction of TACE expression and IL-6Ra shedding regulates airway inflammation. J. Immunol. 175:1930-1936, 2005.
• Thor Wagner, Grace Soong, Sach Sokol, Jonathan Waks and Alice Prince. Azithromycin attenuates expression of Pseudomonas aeruginosa virulence factors associated with CF airway inflammation. Chest.128:912-919, 2005.
• Sadikot, RT, Blackwell TS, Christman JW, and Prince AS. Pathogen-host interactions in Pseudomonas aeruginosa pneumonia: the state of the art. Amer J Resp Crit Care Med. 171:1209-1223, 2005.
• Marisa I Gomez, Aram Lee, Bharat Reddy, Amanda Muir, Grace Soong, Allyson Pitt, Ambrose Cheung, and Alice Prince. Staphylococcus aureus protein A induces airway epithelial inflammatory responses by activating TNFR1. Nature Medicine, July 11, 2004; (DOI).
• Amanda Muir, Grace Soong, Sach Sokol, Bharat Reddy, Marisa I. Gomez, Anna van Heeckeren, and Alice Prince. Toll-Like Receptors in Normal and Cystic Fibrosis Airway Epithelial Cells. Am. J. Respir. Cell Mol. Biol., Jun 2004; 30: 777 - 783.
• Grace Soong, Bharat Reddy, Sach Sokol, Robert Adamo, and Alice Prince. TLR2 is mobilized into an apical lipid raft receptor complex to signal infection in airway epithelial cells. J. Clin. Invest., May 2004; 113: 1482 - 1489.
• Robert Adamo, Sach Sokol, Grace Soong, Marisa I. Gomez, and Alice Prince. Pseudomonas aeruginosa Flagella Activate Airway Epithelial Cells through asialoGM1 and Toll-Like Receptor 2 as well as Toll-Like Receptor 5. Am. J. Respir. Cell Mol. Biol., May 2004; 30: 627 - 634.
• Alice Prince. The host response to anthrax lethal toxin: unexpected observations. J. Clin. Invest., Sep 2003; 112: 656 - 658.
• Alice Prince. Biofilms, Antimicrobial Resistance, and Airway Infection. N. Engl. J. Med., Oct 2002; 347: 1110 - 1111.
• Shahryar Saba, Grace Soong, Steven Greenberg, and Alice Prince. Bacterial Stimulation of Epithelial G-CSF and GM-CSF Expression Promotes PMN Survival in CF Airways. Am. J. Respir. Cell Mol. Biol., Nov 2002; 27: 561 - 567.
• Geoffrey Heyer, Shahryar Saba, Robert Adamo, William Rush, Grace Soong, Ambrose Cheung, and Alice Prince. Staphylococcus aureus agr and sarA Functions Are Required for Invasive Infection but Not Inflammatory Responses in the Lung. Infect. Immun., Jan 2002; 70: 127 - 133.
• Adam J. Weber, Grace Soong, Ruth Bryan, Shahryar Saba, and Alice Prince. Activation of NF-B in airway epithelial cells is dependent on CFTR trafficking and Cl channel function. Am J Physiol Lung Cell Mol Physiol, Jul 2001; 281: 71 - 78.
• Adam J. Ratner, Ruth Bryan, Adam Weber, Stephen Nguyen, Derrick Barnes, Allyson Pitt, Shari Gelber, Ambrose Cheung, and Alice Prince. Cystic Fibrosis Pathogens Activate Ca2+-dependent Mitogen-activated Protein Kinase Signaling Pathways in Airway Epithelial Cells. J. Biol. Chem., May 2001; 276: 19267 - 19275.
• Sujatha Rajan, Grace Cacalano, Ruth Bryan, Adam J. Ratner, Claudia U. Sontich, Anna van Heerckeren, Pamela Davis, and Alice Prince. Pseudomonas aeruginosa Induction of Apoptosis in Respiratory Epithelial Cells . Analysis of the Effects of Cystic Fibrosis Transmembrane Conductance Regulator Dysfunction and Bacterial Virulence Factors. Am. J. Respir. Cell Mol. Biol., Sep 2000; 23: 304 - 312.
• Emily DiMango, A.J. Ratner, R. Bryan, S. Tabibi, and A. Prince. Activation of NF-B by Adherent Pseudomonas aeruginosa in Normal and Cystic Fibrosis Respiratory Epithelial Cells. J. Clin. Invest., Jun 1998; 101: 2598 - 2605.
• Emily DiMango, HJ Zar, R Bryan, and A Prince. Diverse Pseudomonas aeruginosa gene products stimulate respiratory epithelial cells to produce interleukin-8. J. Clin. Invest., Nov 1995; 96(5): 2204-10.
• Lisa Saiman and A Prince. Pseudomonas aeruginosa pili bind to asialoGM1 which is increased on the surface of cystic fibrosis epithelial cells. J. Clin. Invest., Oct 1993; 92(4): 1875-80.
• Grace Cacalano, M Kays, L Saiman, and A Prince. Production of the Pseudomonas aeruginosa neuraminidase is increased under hyperosmolar conditions and is regulated by genes involved in alginate expression. J. Clin. Invest., Jun 1992; 89(6): 1866-74.