Honors:
Undergraduate General Motors Scholarship
Kraft Scholarship
UCLA Scholarship
Phi Beta Kappa
Graduate Fight for Sight Summer Fellow
NSF Predoctoral Fellow
Postdoctoral NIH NRSA
Faculty Alfred P. Sloan Foundation Fellow
Irma T. Hirschl Career Scientist Award

Major Research Interest:
Neuroendocrinology; neuroimmune interactions

Research and/or Professional Experience:
1970-1972 University of Rochester, Department of Anatomy, NIH Postdoctoral  Fellow
1972-1974 University of California, Department of Biology, Los Angeles, California Research Associate
1974-1976 University of Wisconsin, Regional Primate Research Center, Madison, Wisconsin Assistant Scientist, Chief, Neural Ultrastructure Unit
1976 - present Professor, Columbia University, College of Physicians and Surgeons, Department of Anatomy and Cell Biology, New York, NY

Publications: Selected from Bibliography 2000
1. Silverman, AJ, Sutherland, KA, Wilhelm0, M and Silver, R. Mast cells migrate from blood to brain. Accepted J Neuroscience, publication Jan 2000.
2. Wilhelm, M, King, B, Silverman, AJ and Silver, R. Gonadal steroids regulate the number and activational state of mast  cells in the medial habenula. In submission.1999
3. Zhuang, X, Silverman, A.J. and Silver, R. Distribution and local differentiation of mast cells in the parenchyma of the forebrain. J. Comp. Neurol. 408: 477-488
4. Mulrennin, EM Witkin, JW and Silverman, A.J. Embryonic development of the GnRH system in the chick: a spatio-temporal analysis of GnRH neuronal generation, site of origin and migration. Endocrinology 140:422-33. 1998
5. Rogers, M.C., Silverman, A.J. and Gibson, M.J. Preoptic area grants implanted in the mammillary  bodies of hypogonadal mice: patterns of GnRH neuronal projections. Expt'l. Neurology 151: 265-272.
6. Shanas, U, Bhasin, R., Sutherland, AK, Silverman, AJ and Silver, R. Brain mast cells lack the c-kit receptor. J. Neuroimmunology, 90:207-211.
7. Wilhelm, M, Silver, R and Silverman, AJ Mast cells project granular contents into  neurons in the avian brain. Soc. Neuroscience 24:1856. 1997
8. Wu, T.J., Gibson, M.J., Rogers, M.C. and Silverman, A.J.  New Observations on the Development of the GnRH System in the Mouse.  J. Neurobiol. 33: 983-998.
9. Rogers, M.C. Silverman, A.J. and Gibson, M.J.  GnRH Axons Target the Median Eminence: in vitro evidence for Diffusible Chemoattractive Signals from the Medial Basal Hypothalamus.  Endocrinology 138: 3956-3966. 1996
10. Silver, R., Silverman, A.J., Vitkovic, L., and Lederhandler, I. Mast Cells in the Brain: Evidence and Functional Significance. Trends in Neuroscience. 19: 25-31.
11. Wu, T.J., Silverman, A.J., and Gibson, M.J. FOS Expression in Grafted GnRH Neurons in Hypogonadal Mouse: Mating and Steroid Induction.  Journal of Neurobiology 31:67-76.
12. Zhuang, X., Silverman, A.J., and Silver, R. Brain Mast Cell Degranulation Regulates Blood-Brain Barrier.  Journal of Neurobiology 31:393-463.
13. Hilal, E., Chen, J. and Silverman, A.J. Joint Migration of Gonadotropin Releasing Hormone (GnRH) and Neuropeptide Y (NPY) Neurons from Olfactory Placode to CNS. J. Neurobiology 31: 487-501. 1995
14. Miller, G.M., Silverman, A.J., Rogers, M-C and Gibson, M.J. Neuromodulation of transplanted gonadotropin realeasing hormone (GnRH) neurons in male and female hypogonadal mice with preoptic area brain grafts.  Endocrinology. Biol. Reproduction 52: 572-583.
15. Witkin, J.W., O'Sullivan, H.M. and Silverman, A.J. Novel Associations among GnRH neurons.   Endocrinology 136: 4323-4330.
16. Silverman, AJ, Zhuang X and Silver, R.  Central Nervous System Mast Cells and Reproduction. In: The Neurobiology of Puberty. J. Endocrinology, eds. T.M. Plant and P.A. Lee. J. Endocrinology.
17. Sullivan, K.A., Witkin, J.W., Ferin, M., and Silverman, A.J. GnRH neurons in the rhesus macaque are not immunoreactive for the estrogen receptor. Brain Research. 685: 198-200.
18. Wu, T.J., Gibson, M.J., and Silverman, A.J. GnRH neurons of the developing tectum of the mouse. Journal of Neuroendocrinology 7: 899-902. 1994
19. Silverman, A.J., Livne, I., and Witkin, J.W.  The Gonadtropin-Releasing Hormone (GnRH), Neuronal Systems: Immunocytochemistry and In Situ Hybridization. The Physiology of Reproduction
20. Silverman, A.J., Witkin, J.W.  Biosynthesis of GnRH during the rat estrous cycle: a cellular analysis.  Neuroendocrinology  59 545-551.
21. Romero, M.T., Silverman, A.J., Wise, P.M., Witkin, J.W.  Ultrastructural changes in GnRH neurons as a function of age and ovariectomy in rats. Neuroscience  58 217-225.
22. Silverman, A.J., Millar, R.P., King, J.A., Zhuang X., and Silver, R.  Mast cells with GnRH-like immunoreactivity in the brain of doves.  Proc. Nat'l Acad. Sci.  91:3695-99.
23. Silverman, A.J., Livne, I., and Witkin, J.W. The Gonadtropin-Releasing Hormone, Neuronal Systems: Immunocytochemistry and In Situ Hybridization. In: The Physiology of Reproduction, Second Edition, eds. E. Knobil and J.D. Neill, Raven Press, Ltd., New York. 1993
24. Livne, I., Gibson, M.J. and Silverman, A.J.  Biochemiscal differentiation and intercellular interactions of migratory GnRH cells in the mouse. Development Biol. 159:  643-656.
25. Zhuang, C., Silverman, A.J. and Silver, R.  Reproductive behavior, endocrine state and the distribution of GnRH immunoreactive mast cells in dove brain.  Hormones and Behavior.  27: 238 - 259.
26. Silver, R., Zhuang, X., Millar, R., and Silverman, A.J.  Mast cells containing GnRH-like immunocreactivity in the CNS during courtship in doves.  Symposium: Avian Endocrinology.  In: Avian Endocrinology,  P.J. Sharp, ed., Journal of Endocrinology LTD, Bristol.
27. Silverman, A.J., Millar, R.P., King, J.A. and Silver, R.  Mast cells containing GnRH-like immunoreactivity in the central nervous system of the ring dove.  Proc. Nat'l Acad. Sci.  91: 3695-3699.
28. Sullivan, K.A. and Silverman, A.J.  The ontogeny of GnRH neurons in the chick.  Neuroendocrinology. 58: 597-608.