Genetic Algorithm: for optimizing experimental trial design, particularly rapid event-related fMRI. Also mixed block/ER designs, etc.

Wager, T. D. & Nichols, T. E. (2003) Optimization of Experimental Design in fMRI: A General Framework Using a Genetic Algorithm. Neuroimage, 18, 293-309.

Get the software:

Windows (.zip) - Original OptimizeDesign1.1

UNIX / LINUX / Windows (.tar) - OptimizeDesign1.1.2 Updated GA2 algorithm and documentation