The Record Volume 31, No. 7

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R. Glenn Hubbard
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Lisa Anderson
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Victoria de Grazia
Michael Doyle

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Samuel G. Freedman
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June Cross

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Allan Rosenfield
Klaus Lackner

Andrew Marks

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Jeffrey Fagan
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Randall Balmer
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ANDREW MARKS
Chair of Physiology and Cellular Biophysics at the Medical Center

On progress in medicine and science in 2005:

1) Advances in stem cell biology leading to potential novel therapeutics.

2) Nanotechnology for improved local drug delivery.

3) Improved imaging techniques using biological probes. This provides a new understanding of subcellular signaling and hence a more realistic view of how cells work.

What's ahead?

1) New mechanism-based targeted drug therapies will be developed for human diseases, following the gleevec example.

2) We'll see stem cells being used for more effective gene delivery for therapy of human genetic diseases.

3) The therapeutic use of nanotechnology to locally deliver drugs to treat human disease will be combined with novel, biologically-based imaging to measure the efficacy of treatment.

Source of Inspiration in 2005

Doctors from Hell: The Horrific Account of Nazi Experiments on Humans, by Vivien Spitz. A firsthand account of Nazi doctors by a court reporter at the Nuremberg trials, pointing out the horrors of human experimentation and highlighting the necessity of truly informed consent for human studies as well as of prior work in animal models to establish efficacy and safety.