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Friday Synthesis Symposium - Trevor Sherwood

Friday, October 26, 2012 - 4:00pm - 5:00pm
Columbia University Morningside Campus Room 209 Havemeyer

Friday Synthesis Symposium

"Cascade Approaches to Polycyclic Natural Products"

Abstract: Our group focuses on the synthesis of a variety of natural product classes but employs approaches that allow for rapid, scalable assembly of complicated polycyclic architectures using much simpler starting materials and common reagents. Towards this end, our lab has strategically employed cascade reactions to form a variety of natural product cores. In this talk, strategies used to approach the highly immunosuppressant polyphenols dalesconol A and B (1 and 2, Figure 1.) and the dimeric alkaloids psylloborine A and isopsylloborine A (3 and 4, Figure 1.) are discussed in detail. Of particular focus is the formation of the rigid core rings of these molecules surrounding the highly congested quaternary carbon present in each. While these two classes of compounds appear to have little in common, similar philosophies have been employed to assemble their cores, demonstrating the power of ring-forming cascades in the synthesis of natural products as a whole.

Friday Synthesis Symposium
Presented by Trevor Sherwood (Snyder Group)

Friday, October 26, 2012 at 4pm
Room 209 Havemeyer

Categories: Academic: Lecture