Jump to Navigation


The Roche Lecture - Hisashi Yamamoto

Thursday, November 8, 2012 - 4:30pm - 5:30pm
Columbia University, Morningside Campus, Havemeyer Hall, Room 209

The Roche Lecture

"Catalytic Asymmetric Oxidation"
Presented by Hisashi Yamamoto, University of Chicago

Modern drugs are highly functionalized molecules, and often these molecules are chiral.  The most promising solution for production of these molecules has relied on an asymmetric catalytic process, especially catalytic asymmetric oxidation, which can introduce multi functional groups into the molecule.  Thus, we have three sub-projects: 1) asymmetric construction of quaternary carbon using nitroso chemistry.  Nitroso aldol reactions (N-NA and O-NA) were originated by our group and now used extensively by various research groups.  Our objective is to create quaternary carbon centers asymmetrically by NA reaction. 2) Catalytic asymmetric nitroso hetero-Diels-Alder and related asymmetric cycloadditions is powerful method to introduce nitrogen and oxygen to the molecule.  Our copper catalyst is very effective for these transformations. 3) asymmetric epoxidation: New vanadium catalyst was highly effective for asymmetric oxidation of allylic and homoallylic alcohols.  The recently developed catalyst of hafnium was found to be effective asymmetric catalyst of bishomoallylic alcohols and other broad range of substrates

Hosted by Tristan Lambert

Thursday, November 8, 2012

1:30: Meet the Speaker in 328 Havemeyer
4:00: Tea & Cookies in 328 Havemeyer
4:30: Lecture in 209 Havemeyer

Categories: Academic: Lecture